Diversity supplement for the SC2 parent grant

SC2 家长补助金的多元化补充

• 批准号: 10573805
• 负责人: Miguel P Mendez
• 金额: $ 0.71万
• 依托单位: UNIVERSITY OF PUERTO RICO AT AGUADILLA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10573805
• 关键词: Affect; Appointment; Astrocytes; Buffers; Development Plans; Diabetic mouse; Doctor of Philosophy; Electrophysiology (science); Environment; Epilepsy; Exposure to; Female; Funding; Grant; Hippocampus (Brain); Hyperglycemia; Inflammation Mediators; Knowledge; Laboratories; Mus; Neurons; Parents; Postdoctoral Fellow; Potassium; Property; Publishing; Research; Research Personnel; Seizures; TNF gene; Talents; Training; Type 2 diabetic; Work; base; career development; diabetic; experience; experimental study; insight; interest; male; member; neuroinflammation; non-diabetic; parent grant; potassium ion; recruit

This is a diversity supplement to an SC2 Score grant parent grant entitled: “Hippocampal astrocytic Kir4.1 channel function in Type 2 diabetic mice: impact on neuronal hyperexcitability”. The purpose of this request is to provide supplemental funding to support and enhance the training of Ph.D. candidate, Mr. Luis A. Rojas-Colón. The recruitment of Mr. Luis A. Rojas-Colón will allow our laboratory to incorporate neuroinflammation studies that will substantially add to the parent grant and to the laboratory team. With his neuroinflammation Ph.D. training, he will assess if pro-inflammatory mediators could be affecting the ability of astrocytes to buffer potassium ions in the hippocampus and if those pro-inflammatory mediators affect neuronal epileptiform activity. Having Mr. Luis A. Rojas-Colón in the laboratory for the next 2 years would be fitting because of Luis’ research, talent, and interest in neuroinflammation. Since he would share his knowledge with our laboratory members, he will be directly enhancing the diversity environment in our workroom facilitating the qualification of this appointment for a diversity supplement. Through focused discussions, Dr. Miguel P. Méndez-González (PI of the parent grant) and Mr. Luis A. Rojas-Colón, together, have developed new specific aims that will take advantage of our recent published findings and of the parent grant specific aims. In 2020, we published that diabetic male mice display neuronal hyperexcitability and decreased astrocytic K+ conductance. Also, it has been shown that TNF-a reduces astroglia potassium conductance (Köller et al., 1998), while neuronal exposure to IL-1b results in neuronal seizure like activity (Schäfers & Sorkin, 2008). By using Electrophysiology, they will determine the astrocytic and neuronal electrophysiological properties in diabetic and non-diabetic female (control) mice. Overall, the developed experiments in this supplement will provide insight of additional mechanism of how hyperglycemia contributes to epileptiform activity.

这是SC2 Score补助金母公司补助金的多样性补充，标题为：“Hippocampus 2型糖尿病小鼠星形胶质细胞Kir4.1通道功能：对神经元过度兴奋的影响”。 这项请求的目的是提供补充资金，以支持和加强 博士培养候选人路易斯·A.罗哈斯-科隆Luis A.罗哈斯科隆 将使我们的实验室纳入神经炎症研究，这将大大增加 家长补助金和实验室团队。他的神经炎症博士学位。培训，他将评估 如果促炎介质能够影响星形胶质细胞缓冲钾离子的能力， 以及这些促炎介质是否影响神经元癫痫样活动。 路易斯·A.罗哈斯-科隆在实验室里呆上两年是合适的，因为 路易斯在神经炎症方面的研究，天赋和兴趣。因为他愿意分享他的知识 与我们的实验室成员，他将直接加强我们的多样性环境， 协助这一任命获得多样性补助金资格的工作室。 通过重点讨论，Miguel P. Ménég-González博士（母基金的主要负责人）和Ménég-González先生（Ménég-González先生） Luis A. Rojas-Colón共同制定了新的具体目标，将利用我们的 最近公布的调查结果和家长赠款的具体目标。2020年，我们发表了糖尿病患者 雄性小鼠表现出神经元过度兴奋和星形胶质细胞K+传导降低。而且 已经显示TNF-α降低星形胶质细胞钾传导（Köller等，1998年），而 神经元暴露于IL-1b导致神经元癫痫样活动（Schäfers & Sorkin，2008）。通过 使用电生理学，他们将确定星形胶质细胞和神经元的电生理学， 在糖尿病和非糖尿病雌性（对照）小鼠中的特性。总的来说，开发的实验 在本补充中，将提供高血糖症如何影响 癫痫样活动