Social Processing Systems in Veterans with Schizophrenia: Identifying Deficits in Brain Activation and Network Organization

患有精神分裂症的退伍军人的社会处理系统：识别大脑激活和网络组织的缺陷

• 批准号: 10571685
• 负责人: Michael F. Green
• 金额: --
• 依托单位: VA GREATER LOS ANGELES HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-10-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10571685
• 关键词: Address; Affect; Anatomy; Anterior; Antipsychotic Agents; Area; Base of the Brain; Brain; Clinical assessments; Cognition; Diffusion Magnetic Resonance Imaging; Dorsal; Emotional; Emotions; Empathy; Employment; Evaluation; Functional Magnetic Resonance Imaging; Goals; Grant; Image; Impaired cognition; Impairment; Individual; Insula of Reil; Intervention; Knowledge; Lead; Matched Group; Measures; Medial; Mental disorders; Modeling; Monitor; Moods; Pain; Painless; Participant; Pathway Analysis; Patients; Pattern; Perception; Performance; Persons; Pharmaceutical Preparations; Population; Prefrontal Cortex; Process; Psyche structure; Psychotic Disorders; Public Health; Published Comment; Publishing; Recovery; Regulation; Retrieval; Schizophrenia; Seeds; Social Functioning; Stimulus; System; Veterans; Veterans Health Administration; Withdrawal; Work; analytical method; base; cingulate cortex; cost; disability; emotional experience; functional disability; graph theory; indexing; insight; interest; relating to nervous system; segregation; social; social cognition; social deficits; social group; social neuroscience

Schizophrenia is a serious and debilitating psychiatric disorder that affects nearly 1% of the world's population. Within the Veterans Health Administration, total costs in FY 2014 for Veterans with psychotic disorders (of which schizophrenia is the most severe) was over 6 billion dollars. Deficits in cognition – both non-social and social -- are core features of schizophrenia. The deficits in social cognition refer to the processes that are involved in the perception, encoding, storage, retrieval and regulation of information about other people and ourselves. The problems in social cognition underlie the social disability and reduced functioning of the illness. A greater understanding of social cognitive impairments would provide opportunities for targeted recovery- focused interventions. This proposal will address an unanswered question: specifically how and where in the brain social processing goes awry in schizophrenia. We know which social processing brain systems are relevant to understanding schizophrenia. However, we do not know whether social processing impairments emerge within a particular brain system or between systems when they work together (i.e., are integrated). Only some systems are impaired in schizophrenia. For example, mentalizing, which involves taking others' viewpoints, is clearly impaired in schizophrenia. Affect sharing, which is the automatic activation of emotion in ourselves when we see emotional displays in others, is relatively intact. Empathy (i.e. sharing, understanding, and responding to emotional experiences of another person) is a high-level social processing ability that requires integration among processing systems, including affect sharing and mentalizing. Our knowledge of the neural basis of social processing impairments and social disability in schizophrenia is severely lacking, and the goal of this proposal is to address this knowledge gap. The study will use functional magnetic resonance imaging (fMRI) to examine regional brain activity, seed- based connectivity, and brain network organization in 72 Veterans with schizophrenia and 72 group-matched controls. Clinical assessments and performance-based tasks in social cognition will also be included. The aims will be addressed using three social processing paradigms: 1) A Pain Rating Task in which participants view painful and non-painful images. It activates the affect sharing system. 2) A Director's Task in which participants take the same or different viewing perspective as another person. It activates the mentalizing system. And 3) An Empathic Accuracy Task in which participants monitor the mood of a social “target” on a video. It relies on multiple social processing systems, including affect sharing and mentalizing. A close evaluation of activation, connectivity, and brain network organization in social processing brain systems will identify specific points of neural vulnerability in schizophrenia. In that way, we can begin to understand how specific disruptions in neural processes lead to impaired social functioning.

精神分裂症是一种严重的、使人衰弱的精神疾病，影响着世界上近1%的人口。 在退伍军人健康管理局内，2014财年患有精神障碍的退伍军人的总费用（ 其中精神分裂症是最严重的）超过60亿美元。认知缺陷-非社会性和 社会性是精神分裂症的核心特征社会认知的缺陷是指 参与感知、编码、存储、检索和调节有关他人的信息， 我们自己.社会认知的问题是造成社会残疾和功能减退的原因。 更好地理解社会认知障碍将为有针对性的康复提供机会- 重点干预。这一建议将解决一个悬而未决的问题：具体而言， 精神分裂症患者的大脑社会处理过程会出错 我们知道哪些社会处理大脑系统与理解精神分裂症有关。但我们 我不知道社交处理障碍是出现在特定的大脑系统内部还是系统之间 当它们一起工作时（即，整合）。精神分裂症患者只有部分系统受损。为 例如，精神分裂症患者的心智化（mentalizing），即采纳他人的观点，明显受损。影响 分享，也就是当我们看到别人的情绪表现时，我们自己的情绪会自动激活， 相对完整。移情（即分享、理解和回应他人的情感体验） 人）是一种高层次的社会处理能力，需要整合处理系统，包括 影响分享和心理化。我们对社交处理障碍和社交障碍的神经基础的了解 精神分裂症的残疾严重缺乏，本提案的目标是解决这一知识差距。 这项研究将使用功能性磁共振成像（fMRI）来检查局部大脑活动， 在72名退伍军人精神分裂症患者和72名组匹配的 对照临床评估和基于绩效的社会认知任务也将包括在内。的 目标将使用三种社会处理范式来解决：1）疼痛评级任务，其中参与者 观看痛苦和非痛苦的图像。它激活了情感分享系统。2)导演的任务，其中 参与者采取与另一个人相同或不同的观看视角。它激活了精神化 系统和3）移情准确性任务，参与者监测社会“目标”的情绪， 视频.它依赖于多种社会处理系统，包括情感分享和心理化。 社会加工脑的激活、连接和脑网络组织的密切评价 系统将识别精神分裂症的神经脆弱点。这样我们就可以开始 了解神经过程中的特定中断如何导致社会功能受损。