University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)

项目总结-整体组件 南加州大学的南加州大学诺里斯综合癌症中心（NCCC） 自1973年以来一直作为NCI指定的综合癌症中心获得资助。NCCC有着丰富的传统 作为一个主要的区域和国际癌症研究资源， 教育、社区外展和参与以及以患者为中心的肿瘤学护理。我们的愿景是减少 癌症给所有人带来的负担。NCCC的一个核心优先事项是满足以下人群与癌症相关的独特需求： 我们的多元文化集水区，洛杉矶县（LAC）。为了实现这一目标，我们的187名正式成员组成 协作团队，并组织成五个有影响力的研究计划，由六个有价值的共享 资源（工作人员代表）。NCCC的癌症研究培训和教育协调（CRTEC）计划是 这些努力的结构，为下一代杰出的癌症科学家创造了一个多样化的管道 和临床医生。NCCC社区外展和参与办公室（COE）是主要的工具， 我们了解，参与和服务于我们的集水区服务不足的社区的需求。我们 位于全国第四大多元化城市的地理位置为NCCC提供了领导研究的机会 这解决了不同社区和特殊人群之间的癌症负担和差异。的确， NCCC的特点是在招募不同人群进行临床试验方面取得了非凡的成功， 占介入治疗应计费用的61%以上。此应用程序要求：1）支持 五个互动研究项目; 2）部分支持六个SR和一个开发临床前SR， 技术，服务和科学咨询，将加强成员的互动和生产力; 3） 支持领导、规划和评估; 4）支持发展基金，以促进对新的 优先事项，加强科学，探索新的合作和技术，所有这些都与新的NCCC保持一致 战略计划; 5）支持癌症中心管理; 6）支持集中科学监督 癌症临床试验。成员目前持有总额为1.013亿美元（直接成本）的赠款，其中3770万美元来自NCI 并撰写了具有里程碑意义的出版物，代表了高的项目内（26%），项目间 (25%）和多机构（45%）癌症研究。癌症中心支持补助金（Cancer Center Support Grant） （CCSG）将使我们能够建立我们在基础，人口和临床科学方面的优势，并促进 发现并将其转化为对患者和不同社区的直接益处。

PROJECT SUMMARY – Overall Component The USC Norris Comprehensive Cancer Center at the University of Southern California (NCCC) has been continuously funded as an NCI-designated Comprehensive Cancer Center since 1973. NCCC has a rich tradition of collaborative research and serves as a major regional and international resource for cancer research, education, community outreach and engagement, and patient-centered oncology care. Our vision is to reduce the burden of cancer for all people. A central priority for NCCC is to serve the unique cancer-related needs of our multicultural catchment area, Los Angeles County (LAC). To achieve this goal, our 187 full members form collaborative teams and are organized into five impactful Research Programs served by six valuable Shared Resources (SRs). NCCC’s Cancer Research Training and Education Coordination (CRTEC) programs are part of the fabric of these efforts, creating a diverse pipeline for the next generation of exceptional cancer scientists and clinicians. The NCCC Office of Community Outreach and Engagement (COE) is the primary vehicle by which we understand, engage, and serve the needs of the underserved communities in our catchment area. Our geographic location in the 4th most diverse city in the nation affords opportunities for NCCC to lead in research that addresses cancer burdens and disparities among diverse communities and special populations. Indeed, NCCC is distinguished by exceptional success in recruiting diverse populations to clinical trials, with minorities accounting for more than 61% of interventional therapeutic accruals. This application requests: 1) support for five interactive Research Programs; 2) partial support for six SRs and one Developing Preclinical SR that provide technologies, services, and scientific consultation that will enhance member interaction and productivity; 3) support for Leadership, Planning, and Evaluation; 4) support for Developmental Funds to foster pursuit of new priorities, strengthen science, and explore new collaborations and technologies, all aligned with the new NCCC Strategic Plan; 5) support for Cancer Center Administration; and 6) support centralized scientific oversight of cancer clinical trials. Members currently hold grants totaling $101.3M (direct costs) with $37.7M from NCI and have authored landmark publications representing high intra-programmatic (26%), inter-programmatic (25%) and multi-institutional (45%) cancer research. Continued funding from the Cancer Center Support Grant (CCSG) will allow us to build on our strengths in basic, population, and clinical sciences, and to facilitate discovery and its translation into direct benefit to patients and diverse communities.