Mechanisms of Rotator Cuff Injury During Manual Wheelchair Propulsion
手动轮椅推进过程中肩袖损伤的机制
基本信息
- 批准号:10572578
- 负责人:
- 金额:$ 7.44万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-04-01 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAddressAffectAlgorithmsAnatomyApplications GrantsArticular Range of MotionCaregiver BurdenClinicClinicalClinical TrialsCollaborationsCustomDataData SetDevelopmentDimensionsDiseaseElectromyographyFunctional disorderFutureGenetic ModelsGeometryHeadHealthImmobilizationIndividualInstitutionInterventionInvestigationJoint structure of shoulder regionJointsKnowledgeManual wheelchairMeasuresMethodsMinnesotaModelingMotionMovementMuscleMusculoskeletalNational Institute of Child Health and Human DevelopmentOutcomeOutcome AssessmentPainParticipantPathologyPatternPersonsPopulationPositioning AttributePublic HealthQuality of lifeReportingResearchResearch PersonnelResolutionResourcesRiskRotator CuffSample SizeScanningScientistSeveritiesShoulderShoulder PainSiteSoft Tissue DisorderSpinal cord injuryStatistical Data InterpretationStressStructureTechniquesTechnologyTendon InjuriesTendon structureTimeTorqueTransportationUnited StatesUniversitiesUpper ExtremityWeight-Bearing stateWheelchair propulsionWorkarthropathiesboneclinical applicationdesignexperiencefunctional independencehealth care service utilizationimprovedin vivoinjuredinterestkinematicsmultidisciplinarypreservationpressurepreventpreventive interventionreconstructionrepairedrotator cuff injuryrotator cuff tearscapulasecondary analysisskeletalsoft tissue
项目摘要
Project Summary/Abstract
Shoulder pain and joint disease is a serious threat to health and mobility for manual wheelchair users living with
spinal cord injury. There are subsequent implications for functional independence, quality of life, caregiver
burden, and healthcare utilization. In particular, rotator cuff tears are devastating for these individuals as the
usual clinical course (repair) is not typically viable. Their upper extremities have become their primary means of
mobility, and post-surgical shoulder immobilization is impractical. As such, it is critical that shoulder joint health
is preserved for this population. In order to address the major challenges of preventing shoulder disease and
dysfunction progression for manual wheelchair users, we need to assess the impact of and need for various
interventions relative to rotator cuff soft tissue health. In addition to inverse dynamic calculations of joint torques
or electromyographic measures, measuring the impact of interventions on rotator cuff soft tissue compression is
an important advancement in mechanistic understanding and outcomes assessment. Our proposal will combine
existing data sets from the University of Minnesota (20 precise 3D shoulder reconstructions including soft tissue)
and Mayo Clinic (10 participants’ precise 3D shoulder kinematics during wheelchair propulsion) to measure
rotator cuff compression for 200 unique combinations of shoulder geometry and kinematics. Aim 1 will
“Characterize the effect of anatomical features and movement patterns on rotator cuff tendon compression
during manual wheelchair propulsion”. Clinicians and transformational scientists need to know the relative
impacts of motion and anatomy/geometry on rotator cuff stresses during wheelchair propulsion.
Outcomes of this investigation will inform both mechanistic investigations and clinical trials assessing preventive
interventions. In addition, methods to directly assess soft tissue impact are labor- and technology-intensive. Our
proposed Aim 2 will “Determine the capability of low-fidelity models to predict in vivo tendon compression during
manual wheelchair propulsion” by directly comparing high- and low-fidelity techniques. Successful completion
of this project will determine the necessity or benefit of labor-intensive, subject-specific models over
lower fidelity alternatives in studying rotator cuff tendon injury mechanisms, and preventative outcomes.
This knowledge can then be applied extensively in future work by our group and others, including assessment
of transfers and other functional activities. Appropriate sample sizes for future work can also be planned with the
knowledge gained through this proposed project. This project provides a unique opportunity for collaboration
between experienced investigators and to combine existing data to determine relative utility of various
approaches for larger scale investigation planning. Our approach is responsive to the NICHD Notice of Special
Interest (NOT-HD-20-200) in that it leverages valuable existing data to advance understanding of shoulder soft
tissue disease and planning for future investigations by our multidisciplinary groups and others.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
PAULA Marie LUDEWIG其他文献
PAULA Marie LUDEWIG的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('PAULA Marie LUDEWIG', 18)}}的其他基金
Soft Tissue Compression Risk in Rotator Cuff Disease Development
肩袖疾病发展中的软组织受压风险
- 批准号:
8443595 - 财政年份:2013
- 资助金额:
$ 7.44万 - 项目类别:
Subacromial space reductions in rotator cuff disease: Effects on soft tissue
肩袖疾病的肩峰下间隙缩小:对软组织的影响
- 批准号:
7313830 - 财政年份:2007
- 资助金额:
$ 7.44万 - 项目类别:
Biomechanically Based Shoulder Rehabilitation Strategies
基于生物力学的肩部康复策略
- 批准号:
7060841 - 财政年份:2003
- 资助金额:
$ 7.44万 - 项目类别:
Biomechanically Based Shoulder Rehabilitation Strategies
基于生物力学的肩部康复策略
- 批准号:
6894025 - 财政年份:2003
- 资助金额:
$ 7.44万 - 项目类别:
Biomechanically Based Shoulder Rehabilitation Strategies
基于生物力学的肩部康复策略
- 批准号:
6610149 - 财政年份:2003
- 资助金额:
$ 7.44万 - 项目类别:
Biomechanically Based Shoulder Rehabilitation Strategies
基于生物力学的肩部康复策略
- 批准号:
6752526 - 财政年份:2003
- 资助金额:
$ 7.44万 - 项目类别:
Biomechanically Based Shoulder Rehabilitation Strategies
基于生物力学的肩部康复策略
- 批准号:
7226766 - 财政年份:2003
- 资助金额:
$ 7.44万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 7.44万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 7.44万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 7.44万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 7.44万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 7.44万 - 项目类别:
Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 7.44万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 7.44万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 7.44万 - 项目类别:
EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 7.44万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 7.44万 - 项目类别:
Research Grant