Mechanisms of Rotator Cuff Injury During Manual Wheelchair Propulsion

手动轮椅推进过程中肩袖损伤的机制

基本信息

  • 批准号:
    10572578
  • 负责人:
  • 金额:
    $ 7.44万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-04-01 至 2025-03-31
  • 项目状态:
    未结题

项目摘要

Project Summary/Abstract Shoulder pain and joint disease is a serious threat to health and mobility for manual wheelchair users living with spinal cord injury. There are subsequent implications for functional independence, quality of life, caregiver burden, and healthcare utilization. In particular, rotator cuff tears are devastating for these individuals as the usual clinical course (repair) is not typically viable. Their upper extremities have become their primary means of mobility, and post-surgical shoulder immobilization is impractical. As such, it is critical that shoulder joint health is preserved for this population. In order to address the major challenges of preventing shoulder disease and dysfunction progression for manual wheelchair users, we need to assess the impact of and need for various interventions relative to rotator cuff soft tissue health. In addition to inverse dynamic calculations of joint torques or electromyographic measures, measuring the impact of interventions on rotator cuff soft tissue compression is an important advancement in mechanistic understanding and outcomes assessment. Our proposal will combine existing data sets from the University of Minnesota (20 precise 3D shoulder reconstructions including soft tissue) and Mayo Clinic (10 participants’ precise 3D shoulder kinematics during wheelchair propulsion) to measure rotator cuff compression for 200 unique combinations of shoulder geometry and kinematics. Aim 1 will “Characterize the effect of anatomical features and movement patterns on rotator cuff tendon compression during manual wheelchair propulsion”. Clinicians and transformational scientists need to know the relative impacts of motion and anatomy/geometry on rotator cuff stresses during wheelchair propulsion. Outcomes of this investigation will inform both mechanistic investigations and clinical trials assessing preventive interventions. In addition, methods to directly assess soft tissue impact are labor- and technology-intensive. Our proposed Aim 2 will “Determine the capability of low-fidelity models to predict in vivo tendon compression during manual wheelchair propulsion” by directly comparing high- and low-fidelity techniques. Successful completion of this project will determine the necessity or benefit of labor-intensive, subject-specific models over lower fidelity alternatives in studying rotator cuff tendon injury mechanisms, and preventative outcomes. This knowledge can then be applied extensively in future work by our group and others, including assessment of transfers and other functional activities. Appropriate sample sizes for future work can also be planned with the knowledge gained through this proposed project. This project provides a unique opportunity for collaboration between experienced investigators and to combine existing data to determine relative utility of various approaches for larger scale investigation planning. Our approach is responsive to the NICHD Notice of Special Interest (NOT-HD-20-200) in that it leverages valuable existing data to advance understanding of shoulder soft tissue disease and planning for future investigations by our multidisciplinary groups and others.
项目总结/摘要 肩关节疼痛和关节疾病是一个严重威胁的健康和行动能力的手动轮椅使用者生活在 脊髓损伤随后对功能独立、生活质量、照顾者产生影响 负担和医疗利用率。特别是,肩袖撕裂对这些人来说是毁灭性的, 通常的临床过程(修复)通常是不可行的。他们的上肢已经成为他们的主要手段 活动性和术后肩部固定是不切实际的。因此,肩关节健康至关重要 是为这个群体保留的。为了应对预防肩关节疾病的重大挑战, 对于手动轮椅使用者的功能障碍进展,我们需要评估各种 与肩袖软组织健康相关的干预措施。除了关节力矩的逆动力学计算外, 或肌电图测量,测量干预对肩袖软组织压迫的影响, 在机械理解和结果评估方面取得了重要进展。我们的建议将联合收割机 明尼苏达大学的现有数据集(20个精确的3D肩关节重建,包括软组织) 和马约诊所(10名参与者在轮椅推进过程中的精确3D肩部运动学)来测量 肩袖压缩200独特的组合肩几何和运动学。目标1将 “描述解剖特征和运动模式对肩袖肌腱压迫的影响 在手动轮椅推进过程中”。临床医生和转型科学家需要知道相对 轮椅推进过程中运动和解剖结构/几何结构对肩袖应力的影响。 这项研究的结果将为机制研究和评估预防性治疗的临床试验提供信息。 干预措施。此外,直接评估软组织影响的方法是劳动和技术密集型的。我们 提出的目标2将“确定低保真度模型预测体内肌腱压缩的能力, 手动轮椅推进”通过直接比较高保真和低保真技术。成功完成 本项目的实施将决定劳动密集型、特定主题模型的必要性或益处, 在研究肩袖肌腱损伤机制和预防结果中的较低保真度替代品。 这些知识可以广泛应用于我们小组和其他人今后的工作,包括评估 转让和其他职能活动。未来工作的适当样本量也可以通过 通过这个项目获得的知识。该项目提供了一个独特的合作机会 有经验的调查人员之间的,并结合联合收割机现有的数据,以确定相对效用的各种 更大规模的调查规划。我们的做法是响应NICHD特别通知 兴趣(NOT-HD-20-200)在于它利用有价值的现有数据来促进对肩关节软组织的理解 组织疾病和规划未来的调查,由我们的多学科小组和其他人。

项目成果

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PAULA Marie LUDEWIG其他文献

PAULA Marie LUDEWIG的其他文献

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{{ truncateString('PAULA Marie LUDEWIG', 18)}}的其他基金

Soft Tissue Compression Risk in Rotator Cuff Disease Development
肩袖疾病发展中的软组织受压风险
  • 批准号:
    8443595
  • 财政年份:
    2013
  • 资助金额:
    $ 7.44万
  • 项目类别:
Subacromial space reductions in rotator cuff disease: Effects on soft tissue
肩袖疾病的肩峰下间隙缩小:对软组织的影响
  • 批准号:
    7313830
  • 财政年份:
    2007
  • 资助金额:
    $ 7.44万
  • 项目类别:
Biomechanically Based Shoulder Rehabilitation Strategies
基于生物力学的肩部康复策略
  • 批准号:
    7060841
  • 财政年份:
    2003
  • 资助金额:
    $ 7.44万
  • 项目类别:
Biomechanically Based Shoulder Rehabilitation Strategies
基于生物力学的肩部康复策略
  • 批准号:
    6610149
  • 财政年份:
    2003
  • 资助金额:
    $ 7.44万
  • 项目类别:
Biomechanically Based Shoulder Rehabilitation Strategies
基于生物力学的肩部康复策略
  • 批准号:
    6894025
  • 财政年份:
    2003
  • 资助金额:
    $ 7.44万
  • 项目类别:
Biomechanically Based Shoulder Rehabilitation Strategies
基于生物力学的肩部康复策略
  • 批准号:
    6752526
  • 财政年份:
    2003
  • 资助金额:
    $ 7.44万
  • 项目类别:
Biomechanically Based Shoulder Rehabilitation Strategies
基于生物力学的肩部康复策略
  • 批准号:
    7226766
  • 财政年份:
    2003
  • 资助金额:
    $ 7.44万
  • 项目类别:

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