Aversion signals in the reward system

奖励系统中的厌恶信号

基本信息

  • 批准号:
    10570985
  • 负责人:
  • 金额:
    $ 43.38万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-04-15 至 2025-02-28
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Aversive environmental events influence the daily lives of all people by altering their emotional states, decision making, and motivated behavior. For individuals with substance abuse disorders who are attempting to remain abstinent, these unfortunate events are clinically relevent, as they are frequently cited as a principle cause of relapse. In order to develop strategies to protect against this important determinant of relapse, it is essential to characterize the mechanisms through which aversive stimuli influence motivational neural circuitry. To this end, several decades of research have identified the nucleus accumbens (NAc) as a critical limbic/motor interface, heavily regulated by dopamine, where affective and associative reward information directly influence behavioral output. Unfortunately, the manner by which aversive stimuli regulate dopamine signaling remains poorly understood, with several studies producing conflicting results. We have identified an aversion signal, initiated by aversion-induced reductions in dopamine concentration, that is associated with increased striatal activity and drug seeking. The objective of this proposal is to determine how aversive stimuli regulate NAc dopamine signaling and the mechanisms through which reductions in dopamine alter neuronal activity in the NAc to shape behavior. To accomplish this objective, the proposal brings together a multi-disciplinary team that will use in vivo fast scan cyclic voltammetry, in vivo electrophysiology, and ex vivo slice electrophysiology to examine the independent contributions of reduced dopamine signaling and increased striatal activity to a panel of aversion- related behaviors, including drug seeking, and both reward and punishment sensitivity. In Aim 1 we will test the hypothesis that aversive stimuli, via reductions in NAc dopamine activate a subpopulation of aversion-responsive D2-like receptor-expressing NAc neurons to produce aversion-related behavioral responses. In Aim 2 we test the hypothesis that aversive stimuli increase corticotropin releasing factor (CRF) in the ventral tegmental area (VTA) and reduce dopamine in the NAc through a CRFR1- and GABAB receptor-dependent regulation of Girk channels on VTA DA neurons that project to the NAc shell. In Aim 3 we will examine upstream pathways that mediate the effects of aversive stimuli on NAc dopamine and behavior and will test the hypothesis that a beta adrenergic receptor-regulated pathway from the ventral bed nucleus of the stria terminalis to the VTA represents one such pathway. Understanding how aversive stimuli alter NAc dopamine signaling and how such alterations encode behavior has implications for understanding and treating a range of stress-related neuropsychiatric conditions including addiction and depression.
项目总结

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Learned avoidance requires VTA KOR-mediated reductions in dopamine.
习得性回避需要 VTA KOR 介导的多巴胺减少。
  • DOI:
    10.1016/j.neuropharm.2020.107996
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    4.7
  • 作者:
    Robble,MykelA;Bozsik,MaryE;Wheeler,DanielS;Wheeler,RobertA
  • 通讯作者:
    Wheeler,RobertA
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

John R. Mantsch其他文献

Aversion-induced dopamine reductions predict drug-taking and escape behaviors
厌恶诱导的多巴胺减少预测吸毒和逃避行为
  • DOI:
    10.1038/s41386-025-02101-7
  • 发表时间:
    2025-04-09
  • 期刊:
  • 影响因子:
    7.100
  • 作者:
    Elaine M. Grafelman;Bridgitte E. Côté;Lisa Vlach;Ella Geise;G. Nino Padula;Daniel S. Wheeler;Matthew C. Hearing;John R. Mantsch;Robert A. Wheeler
  • 通讯作者:
    Robert A. Wheeler
A Computational Approach to Analyzing Spatiotemporal Trends in Gun Violence and Mental Health Disparities among Racialized Communities in US Metropolitan Areas
Glucocorticoid–endocannabinoid interactions in the prelimbic cortex mediate stress-potentiated reinstatement of cocaine seeking
  • DOI:
    10.1016/j.drugalcdep.2014.09.470
  • 发表时间:
    2015-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Jayme R. McReynolds;Oliver Vranjkovic;Evan N. Graf;Cecilia J. Hillard;John R. Mantsch
  • 通讯作者:
    John R. Mantsch
Concomitant adrenal hormonal stress responses are required for cocaine-induced locomotor sensitization
  • DOI:
    10.1016/j.drugalcdep.2014.09.553
  • 发表时间:
    2015-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    David F. Pena;Lisa M. Keller;Conor B. Masterson;Eric J. Cottor;John R. Mantsch
  • 通讯作者:
    John R. Mantsch

John R. Mantsch的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('John R. Mantsch', 18)}}的其他基金

Aversion signals in the reward system
奖励系统中的厌恶信号
  • 批准号:
    9906889
  • 财政年份:
    2019
  • 资助金额:
    $ 43.38万
  • 项目类别:
Aversion signals in the reward system
奖励系统中的厌恶信号
  • 批准号:
    10357863
  • 财政年份:
    2019
  • 资助金额:
    $ 43.38万
  • 项目类别:
THPB-Containing Herbal Preparations for the Treatment of Drug Abuse
用于治疗药物滥用的含有 THPB 的草药制剂
  • 批准号:
    7783842
  • 财政年份:
    2009
  • 资助金额:
    $ 43.38万
  • 项目类别:
THPB-Containing Herbal Preparations for the Treatment of Drug Abuse
用于治疗药物滥用的含有 THPB 的草药制剂
  • 批准号:
    7661335
  • 财政年份:
    2009
  • 资助金额:
    $ 43.38万
  • 项目类别:
THPB-Containing Herbal Preparations for the Treatment of Drug Abuse
用于治疗药物滥用的含有 THPB 的草药制剂
  • 批准号:
    7839349
  • 财政年份:
    2009
  • 资助金额:
    $ 43.38万
  • 项目类别:
Stress response and HPA regulation in cocaine addiction
可卡因成瘾中的应激反应和 HPA 调节
  • 批准号:
    6560344
  • 财政年份:
    2002
  • 资助金额:
    $ 43.38万
  • 项目类别:
GCs, CRF and Stressor-Induced Relapse
GC、CRF 和压力源诱发的复发
  • 批准号:
    8212440
  • 财政年份:
    2002
  • 资助金额:
    $ 43.38万
  • 项目类别:
GCs, CRF and Stressor-Induced Relapse
GC、CRF 和压力源诱发的复发
  • 批准号:
    7791278
  • 财政年份:
    2002
  • 资助金额:
    $ 43.38万
  • 项目类别:
Stress response and HPA regulation in cocaine addiction
可卡因成瘾中的应激反应和 HPA 调节
  • 批准号:
    7275351
  • 财政年份:
    2002
  • 资助金额:
    $ 43.38万
  • 项目类别:
Stress response and HPA regulation in cocaine addiction
可卡因成瘾中的应激反应和 HPA 调节
  • 批准号:
    7106361
  • 财政年份:
    2002
  • 资助金额:
    $ 43.38万
  • 项目类别:

相似海外基金

Affective Computing Models: from Facial Expression to Mind-Reading
情感计算模型:从面部表情到读心术
  • 批准号:
    EP/Y03726X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 43.38万
  • 项目类别:
    Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
  • 批准号:
    2336167
  • 财政年份:
    2024
  • 资助金额:
    $ 43.38万
  • 项目类别:
    Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
  • 批准号:
    2402691
  • 财政年份:
    2024
  • 资助金额:
    $ 43.38万
  • 项目类别:
    Standard Grant
Affective Computing Models: from Facial Expression to Mind-Reading ("ACMod")
情感计算模型:从面部表情到读心术(“ACMod”)
  • 批准号:
    EP/Z000025/1
  • 财政年份:
    2024
  • 资助金额:
    $ 43.38万
  • 项目类别:
    Research Grant
Individual differences in affective processing and implications for animal welfare: a reaction norm approach
情感处理的个体差异及其对动物福利的影响:反应规范方法
  • 批准号:
    BB/X014673/1
  • 财政年份:
    2024
  • 资助金额:
    $ 43.38万
  • 项目类别:
    Research Grant
Interface: Transplants, Aesthetics and Technology (Previously About Face: The affective and cultural history of face transplants)
界面:移植、美学和技术(之前关于面部:面部移植的情感和文化历史)
  • 批准号:
    MR/Y011627/1
  • 财政年份:
    2024
  • 资助金额:
    $ 43.38万
  • 项目类别:
    Fellowship
Tracing the brain mechanisms of affective touch.
追踪情感触摸的大脑机制。
  • 批准号:
    23K19678
  • 财政年份:
    2023
  • 资助金额:
    $ 43.38万
  • 项目类别:
    Grant-in-Aid for Research Activity Start-up
Affective and Immaterial Labour in Latin(x) American Culture
拉丁美洲文化中的情感和非物质劳动
  • 批准号:
    AH/V015834/2
  • 财政年份:
    2023
  • 资助金额:
    $ 43.38万
  • 项目类别:
    Fellowship
Imagination under Racial Capitalism: the Affective Salience of Racialised and Gendered Tropes of 'Black excellence'
种族资本主义下的想象力:“黑人卓越”的种族化和性别化比喻的情感显着性
  • 批准号:
    2889627
  • 财政年份:
    2023
  • 资助金额:
    $ 43.38万
  • 项目类别:
    Studentship
Home/bodies: Exploring the affective experiences of people at home using scenographic practice and ecological thinking
家/身体:利用场景实践和生态思维探索人们在家中的情感体验
  • 批准号:
    2888014
  • 财政年份:
    2023
  • 资助金额:
    $ 43.38万
  • 项目类别:
    Studentship
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了