Momentary Bio-Behavioral Predictors of Loss of Control Eating and Weight Outcomes

饮食失控和体重结果的瞬时生物行为预测因子

• 批准号: 10574529
• 负责人: Gail A. Kerver
• 金额: $ 13.34万
• 依托单位: SANFORD RESEARCH NORTH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10574529
• 关键词: Binge eating disorder; Biological; Blood Glucose; Body Weight; Body Weight decreased; Data; Eating; Eating Behavior; Eating Disorders; Environment; Hypoglycemia; Impairment; Individual; Intervention; Link; Measures; Mediating; Mediation; Medical; Methods; Modeling; Morbid Obesity; Neurocognitive; Obesity; Operative Surgical Procedures; Outcome; Pathologic; Patient Self-Report; Patients; Population; Process; Psychology; Psychopathology; Public Health; Quality of life; Questionnaires; Research; Research Personnel; Resolution; Self-control as a personality trait; Testing; Time; Weight; bariatric surgery; biobehavior; biopsychosocial; clinically relevant; clinically significant; comorbidity; effective intervention; experience; improved; insight; loss of control over eating; negative affect; negative emotional state; novel; physical conditioning; prospective; prospective test; psychologic; psychological distress; weight loss intervention

Momentary bio-behavioral predictors of loss of control eating and weight outcomes PROJECT SUMMARY/ABSTRACT Loss of control (LOC) eating is problematic for individuals with obesity due to its’ negative impact on weight loss efforts. Despite bariatric surgery being the most effective intervention for weight loss among this population, LOC eating following surgery has been repeatedly linked to poor weight outcomes. This highlights the importance of elucidating bio-behavioral mechanisms of LOC eating as an important step in improving weight outcomes following bariatric surgery. Theoretical and empirical evidence supports self-control (i.e., inhibitory control) as the mechanism through which negative affect (NA) prompts LOC eating. While traditionally measured among populations with eating disorders and obesity using retrospective self-report questionnaires, this mechanistic process has yet to be examined in real-time in the natural environment of bariatric surgery patients. Additionally, there is accumulating evidence that low blood glucose (i.e., hypoglycemia) may impact the relationship between inhibitory control and LOC eating among this population. Therefore, the proposed project seeks to test the prospective relationships between NA, inhibitory control, hypoglycemia, and LOC eating in real-time and examine their collective contribution on longitudinal weight outcomes post-bariatric surgery. Specifically, this project will test a moderated mediation model hypothesizing that momentary deficits in inhibitory control will mediate the relationship between NA and LOC eating. Further, it is hypothesized that hypoglycemia will moderate the effect between inhibitory control and LOC eating. Collectively, we anticipate that the more frequent and severe LOC eating resulting from the interplay between negative affect, inhibitory control, and hypoglycemia will then prospectively predict a poorer weight outcome over the following year. By identifying momentary mechanisms of LOC eating, this research has the potential to inform treatment intervention efforts aimed at reducing LOC eating post-surgery and promote more optimal weight outcomes.

饮食失控和体重结果的瞬时生物行为预测因子 项目总结/摘要 由于饮食失控对体重的负面影响， 损失的努力。尽管减肥手术是减肥最有效的干预措施， 在大多数人群中，手术后的过度饮食一再与体重结果不佳有关。这凸显 阐明LOC饮食的生物行为机制作为改善的重要一步的重要性 减肥手术后的体重结果。理论和经验证据支持自我控制（即， 抑制控制）的机制，通过这种机制，负面影响（NA）提示进食。而 传统上使用回顾性自我报告在饮食失调和肥胖人群中进行测量 调查问卷，这一机械过程尚未在自然环境中进行实时检查， 减肥手术病人此外，有越来越多的证据表明，低血糖（即， 低血糖）可能影响该人群中抑制控制和暴食之间的关系。 因此，拟议的项目旨在测试NA，抑制控制， 低血糖，以及实时进食，并检查它们对纵向体重的集体贡献 减肥手术后的结果。具体来说，这个项目将测试一个温和的调解模型假设， 抑制控制的短暂缺陷将介导NA和进食之间的关系。此外，本发明还 假设低血糖会缓和抑制控制和进食之间的影响。 总的来说，我们预计，更频繁和更严重的暴食症是由以下因素的相互作用造成的： 负性情绪、抑制控制和低血糖将预测较差的体重结果 在接下来的一年里。通过识别暴食的瞬时机制，这项研究有可能 为旨在减少术后进食的治疗干预工作提供信息， 体重结果。