Momentary Bio-Behavioral Predictors of Loss of Control Eating and Weight Outcomes

饮食失控和体重结果的瞬时生物行为预测因子

• 批准号: 10574529
• 负责人: Gail A. Kerver
• 金额: $ 13.34万
• 依托单位: SANFORD RESEARCH NORTH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10574529
• 关键词: Binge eating disorder; Biological; Blood Glucose; Body Weight; Body Weight decreased; Data; Eating; Eating Behavior; Eating Disorders; Environment; Hypoglycemia; Impairment; Individual; Intervention; Link; Measures; Mediating; Mediation; Medical; Methods; Modeling; Morbid Obesity; Neurocognitive; Obesity; Operative Surgical Procedures; Outcome; Pathologic; Patient Self-Report; Patients; Population; Process; Psychology; Psychopathology; Public Health; Quality of life; Questionnaires; Research; Research Personnel; Resolution; Self-control as a personality trait; Testing; Time; Weight; bariatric surgery; biobehavior; biopsychosocial; clinically relevant; clinically significant; comorbidity; effective intervention; experience; improved; insight; loss of control over eating; negative affect; negative emotional state; novel; physical conditioning; prospective; prospective test; psychologic; psychological distress; weight loss intervention

Momentary bio-behavioral predictors of loss of control eating and weight outcomes PROJECT SUMMARY/ABSTRACT Loss of control (LOC) eating is problematic for individuals with obesity due to its’ negative impact on weight loss efforts. Despite bariatric surgery being the most effective intervention for weight loss among this population, LOC eating following surgery has been repeatedly linked to poor weight outcomes. This highlights the importance of elucidating bio-behavioral mechanisms of LOC eating as an important step in improving weight outcomes following bariatric surgery. Theoretical and empirical evidence supports self-control (i.e., inhibitory control) as the mechanism through which negative affect (NA) prompts LOC eating. While traditionally measured among populations with eating disorders and obesity using retrospective self-report questionnaires, this mechanistic process has yet to be examined in real-time in the natural environment of bariatric surgery patients. Additionally, there is accumulating evidence that low blood glucose (i.e., hypoglycemia) may impact the relationship between inhibitory control and LOC eating among this population. Therefore, the proposed project seeks to test the prospective relationships between NA, inhibitory control, hypoglycemia, and LOC eating in real-time and examine their collective contribution on longitudinal weight outcomes post-bariatric surgery. Specifically, this project will test a moderated mediation model hypothesizing that momentary deficits in inhibitory control will mediate the relationship between NA and LOC eating. Further, it is hypothesized that hypoglycemia will moderate the effect between inhibitory control and LOC eating. Collectively, we anticipate that the more frequent and severe LOC eating resulting from the interplay between negative affect, inhibitory control, and hypoglycemia will then prospectively predict a poorer weight outcome over the following year. By identifying momentary mechanisms of LOC eating, this research has the potential to inform treatment intervention efforts aimed at reducing LOC eating post-surgery and promote more optimal weight outcomes.

暂时的生物行为饮食和体重结局的损失的预测指标 项目摘要/摘要 失去控制（LOC）饮食对肥胖的人的负面影响是有问题的 损失工作。尽管减肥手术是减肥最有效的干预措施 人口，手术后的LOC饮食与体重不佳的结果反复有关。这突出了 阐明LOC饮食的生物行为机制的重要性是改善的重要一步 减肥手术后的体重结局。理论和经验证据支持自我控制（即 抑制控制）作为负面影响（NA）促使LOC饮食的机制。尽管 传统上，使用回顾性自我报告，在饮食失调和肥胖的种群中衡量 问卷调查，这种机械过程尚未在自然环境中实时检查 减肥手术患者。此外，还有积累的证据表明低血糖（即 低血糖可能会影响该人群中抑制性控制与LOC饮食之间的关系。 因此，拟议的项目试图测试NA，抑制性控制， 低血糖和实时进食，并检查其对纵向重量的集体贡献 结局后手术。具体而言，该项目将测试假设的调解模型 暂时的定义抑制性控制将介导NA和LOC饮食之间的关系。更远， 假设低血糖会缓解抑制性控制和LOC饮食之间的影响。 总体而言，我们预计，越来越频繁，严重的饮食是由 负面影响，抑制性控制和低血糖症将前瞻性预测体重较差的结果 在接下来的一年中。通过识别LOC饮食的瞬时机制，这项研究具有潜力 为旨在减少手术后的LOC饮食并促进更佳的治疗干预工作。 体重成果。