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Challenging Allergies: The Search for a Magic Bullet for Pediatric Food Allergies

挑战过敏：寻找治疗儿童食物过敏的灵丹妙药

基本信息

批准号：
10578414
负责人：
JILL A FISHER
金额：
$ 4.95万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-12 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10578414
关键词：
Accidents Adolescent Advocate Affect Allergens Allergic Allergy to peanuts American Benefits and Risks Biomedical Research Black race Books Cessation of life Child Childhood Clinic Clinical Trials Data Development Empirical Research Enrollment Ethnic Population Ethnography Family Food Food Hypersensitivity Funding Grant Guidelines Health Hypersensitivity Interview Investments Life Literature Low income Magic Manuscripts Marketing Medical Modeling Parents Pathway interactions Patients Perception Pharmaceutical Preparations Pharmacologic Substance Powder dose form Private Practice Privatization Protocols documentation Public Health Qualifying Quality of life Reaction Reporter Research Research Personnel Risk Safety Sales Sampling Social Sciences Stress Structure Therapeutic Therapeutic Intervention Treatment/Psychosocial Effects Underrepresented Minority United States United States Food and Drug Administration United States National Institutes of Health Work Writing aged clinical practice effective therapy experience food allergen food avoidance innovation interest lens novel therapeutics racial population recruit research and development risk perception treatment comparison urban area

项目摘要

PROJECT SUMMARY This project proposes empirical research and a scholarly book on the medicalization and pharmaceuti- calization of food allergies. One out of every 13 US children has a food allergy, and nearly half of those children are allergic to multiple foods. Because food allergies can be life-threatening, a significant amount of biomedical research and development has been invested in finding effective therapies. These novel therapeutic options—including one recent FDA-approved drug, an array of clinical trials, and even un- regulated food-based treatments—have attracted considerable parental interest despite potentially sig- nificant risks. Indeed, preliminary research indicates that parents often have a higher tolerance for the risks of these medical treatments compared to the risks from food. I am currently completing an ethnographic study of peanut allergy clinical trials, and the proposed project will expand and continue this line of research for the scholarly book through three specific aims: (1) ex- plore the experiences and perceptions of parents of children with peanut or other food allergies who have not pursued clinical trials, (2) document how unregulated food allergy treatments are being offered through private practices, and (3) integrate empirical findings from Aims 1 & 2 with my current ethno- graphic work on food allergy clinical trial participation. For Aim 1, I will conduct 30 interviews with par- ents who are (a) practicing avoidance of their children's food allergens with no additional treatment, (b) treating their children's peanut allergy with the FDA-approved drug, or (c) treating their children's food allergies with unregulated therapies. For Aim 2, I will conduct 10 interviews with clinicians who offer unregulated food-based treatments for food allergies to analyze how they describe their practices, includ- ing any safety protocols they have in place. The book manuscript will be written as part of Aim 3, wherein I will use data from both projects to provide a comprehensive view of food allergy therapeutics. The proposed project is significant because it will provide rich information about how US families navi- gate food allergies as a part of everyday life as well as a condition that increasingly justifies risky thera- peutic interventions. This project is innovative because food allergy therapeutics have not been examined from a critical social science perspective, and there has been no empirical research comparing the per- spectives of parents who choose different medical pathways to manage their children's food allergies or comparing how stakeholders perceive potential differences between FDA-approved, investigational, and unregulated food allergy treatments. Food allergies are certainly a health threat, but this new era of food allergy therapeutics marks a transition in which the condition is being more intensely and problematically medicalized.

项目总结