Studying pseudogout using naturallanguage processing and novelimaging approaches

使用自然语言处理和新颖的成像方法研究假性痛风

• 批准号: 10578683
• 负责人: Sara K. Tedeschi
• 金额: $ 17.65万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10578683
• 关键词: Acute; Affect; Age; Agreement; Algorithms; American; Arthritis; Award; Bioinformatics; Biological Markers; Calcium; Calcium Pyrophosphate; Calcium pyrophosphate deposition disease; Cardiovascular Diseases; Case/Control Studies; Chronic; Clinic; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Code; Cohort Studies; Complement; Computerized Medical Record; Conflict (Psychology); Data; Data Set; Detection; Development; Diagnosis; Diphosphates; Diuretics; Environment; Equipment; Event; Female; Flare; Foundations; Funding; Future; Goals; Gout; Grant; Healthcare; Hospitals; Hypersensitivity; Image; Immunology; Inflammatory; Inflammatory Arthritis; Infrastructure; Institution; Insurance Claim Review; Interleukin-1 beta; Intervention; Ischemic Stroke; Joints; Knowledge; Link; Longitudinal Studies; Machine Learning; Manuscripts; Medicare claim; Medicine; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methods; Modality; Morbidity - disease rate; Myocardial Infarction; Natural Language Processing; Outcome; Outcome Measure; Outcomes Research; Pain; Patients; Performance; Pharmaceutical Preparations; Physicians; Polyarthritides; Population; Positioning Attribute; Predictive Value; Prevalence; Prevention strategy; Productivity; Proton Pump Inhibitors; Pseudogout; Public Health Schools; Publishing; Questionnaires; Research; Research Personnel; Resources; Rheumatoid Arthritis; Rheumatology; Risk; Risk Factors; Roentgen Rays; Science; Serum; Specificity; Synovial Fluid; Techniques; Testing; Time; Training; United States National Institutes of Health; Validation; Vascular calcification; Vascularization; Visit; Wages; Woman; Work; X-Ray Computed Tomography; accurate diagnosis; bisphosphonate; calcium indicator; cardiovascular disorder risk; cardiovascular risk factor; career; career development; cohort; disorder risk; epidemiology study; experience; high risk; human old age (65+); imaging modality; instructor; longitudinal course; medical schools; modifiable risk; mortality; mortality risk; musculoskeletal imaging; musculoskeletal ultrasound; novel; patient health information; patient oriented; predictive modeling; prevent; prognostic; prospective; recruit; research and development; sex; side effect; stem; structured data; targeted treatment; ultrasound; unnecessary treatment

Candidate: Dr. Tedeschi is an Instructor in Medicine at Harvard Medical School (HMS) and Associate Physician in the Division of Rheumatology, Immunology and Allergy’s Section of Clinical Sciences (SCS) at Brigham and Women’s Hospital (BWH). She received an MPH from the Harvard T.H. Chan School of Public Health (HSPH). Her 10 first-author manuscripts, two BWH grants, and foundation award exemplify her productivity and commitment to research. She has assembled an experienced team of mentors and collaborators, led by Dr. Daniel Solomon (primary mentor) and Drs. Katherine Liao and Karen Costenbader (co-mentors), to guide her training in natural language processing and machine learning approaches for clinical research, analysis of linked electronic medical record (EMR) and Medicare claims data, and interpretation of advanced imaging modalities. Focused coursework at HSPH and HMS will complement the experience she gains through her proposed studies of pseudogout risk factors and long-term outcomes. Training in dual- energy CT and ultrasound interpretation for crystalline arthritis will be obtained via one-on-one sessions. Her long-term career goal is to become an independent patient-oriented investigator focused on pseudogout. Environment: Dr. Tedeschi has a commitment from her Division for >75% protected time for research and career development activities during the K23 award period. Support from the Division and her primary mentor’s research funds will supplement her salary and project-related expenses. The SCS, a collaborative clinical research group in the Division of Rheumatology, has extensive infrastructure including the VERITY Bioinformatics Core (NIH-P30-AR072577, PI: Solomon) that will provide resources and expertise for the proposed studies. In addition, the BWH Arthritis Center is one of the largest nationally, facilitating subject recruitment, and the BWH Division of Musculoskeletal Imaging has state-of-the-art equipment and expertise applying dual-energy CT in crystalline arthritis. Coursework at HSPH and HMS, adjacent to BWH, will provide training necessary for Dr. Tedeschi’s development into an independent investigator. Research: Dr. Tedeschi’s long-term objective is to prevent and reduce morbidity from pseudogout, an understudied, painful crystalline arthritis that affects 8-10 million Americans. She will use natural language processing and machine learning approaches to enhance an algorithm for identifying pseudogout in EMR data. She will study risk factors for and long-term outcomes in pseudogout, harnessing vast amounts of information contained in Partners HealthCare EMR data and Medicare claims data, and will gain experience working with linked datasets. Dr. Tedeschi will recruit subjects with pseudogout and other types of mono- and oligoarthritis to test and compare the performance of dual-energy CT scanning, musculoskeletal ultrasound, and x-ray for identifying pseudogout. Her proposed K23 projects will lead to manuscripts and data to be leveraged in an R01 application focused on pseudogout during the award period, leading to independence as a patient-oriented investigator.

候选人：Tedeschi 博士是哈佛医学院 (HMS) 的医学讲师和副教授 临床科学 (SCS) 风湿病学、免疫学和过敏科医师 布莱根妇女医院 (BWH)。她获得了哈佛大学公共卫生学院的公共卫生硕士学位。陈公立学校 健康（HSPH）。她的 10 篇第一作者手稿、两项 BWH 资助和基金会奖就是她的例证 生产力和对研究的承诺。她组建了一支经验丰富的导师团队 合作者，由 Daniel Solomon 博士（主要导师）和 Drs. 领导。凯瑟琳·廖和凯伦·科斯滕巴德 （共同导师），指导她在临床自然语言处理和机器学习方法方面的培训 研究、链接电子病历 (EMR) 和医疗保险索赔数据的分析以及解释 先进的成像方式。 HSPH 和 HMS 的重点课程将补充她的经验 通过她提出的假性痛风危险因素和长期结果的研究获得了收益。双元培训 结晶性关节炎的能量 CT 和超声解释将通过一对一的会议获得。她 长期职业目标是成为一名专注于假性痛风、以患者为中心的独立研究者。 环境：Tedeschi 博士的部门承诺提供 >75% 的受保护时间用于研究和 K23奖励期间的职业发展活动。来自该部门和她的主要导师的支持 研究经费将补充她的工资和项目相关费用。 SCS，一个协作临床 风湿病科的研究小组拥有广泛的基础设施，包括 VERITY 生物信息学核心（NIH-P30-AR072577，PI：所罗门）将为 拟议的研究。此外，BWH 关节炎中心是全国最大的关节炎中心之一， BWH 肌肉骨骼影像部门拥有最先进的设备和专业知识 双能CT在结晶性关节炎中的应用毗邻 BWH 的 HSPH 和 HMS 的课程将提供 Tedeschi 博士成长为独立研究者所必需的培训。研究：Tedeschi 博士的 长期目标是预防和减少假痛风的发病率，假痛风是一种尚未得到充分研究的疼痛结晶 关节炎影响着 8-1000 万美国人。她将使用自然语言处理和机器学习 增强用于识别 EMR 数据中的假性痛风的算法的方法。她将研究和 利用 Partners HealthCare 中包含的大量信息，研究假性痛风的长期结果 EMR 数据和医疗保险索赔数据，并将获得使用链接数据集的经验。特德斯基博士将 招募患有假痛风和其他类型的单关节炎和少关节炎的受试者来测试和比较 双能 CT 扫描、肌肉骨骼超声和 X 线检查用于识别假性痛风。 她提出的 K23 项目将产生手稿和数据，用于 R01 应用程序，重点关注 获奖期间的假性痛风，导致独立作为以患者为导向的研究者。

项目成果

Giant cell arteritis treatment patterns and rates of serious infections.

• DOI: 10.55563/clinexprheumatol/uonz1p
• 发表时间: 2022-05
• 期刊: Clinical and experimental rheumatology
• 影响因子: 3.7
• 作者: Tedeschi SK;Jin Y;Vine S;Lee H;Pethoe-Schramm A;Yau V;Kim SC
• 通讯作者: Kim SC

Unexpected Closure.

• DOI: 10.1056/nejmp2119328
• 发表时间: 2022-06-23
• 期刊: NEW ENGLAND JOURNAL OF MEDICINE
• 影响因子: 158.5
• 作者: Tedeschi, Sara

Review: Outcome measures in calcium pyrophosphate deposition.

• DOI: 10.1016/j.berh.2021.101724
• 发表时间: 2021-12
• 期刊: Best practice & research. Clinical rheumatology
• 作者: Cai K;Tedeschi SK
• 通讯作者: Tedeschi SK

The 2023 ACR/EULAR classification criteria for calcium pyrophosphate deposition disease.

• DOI: 10.1136/ard-2023-224575
• 发表时间: 2023-10
• 期刊: Annals of the rheumatic diseases
• 影响因子: 27.4

Acceptability of Vaccines Against Preventable Infections Including Coronavirus Disease 2019 Among Patients With Rheumatic Disease.

• DOI: 10.1002/acr2.11351
• 发表时间: 2022-01
• 期刊: ACR open rheumatology
• 影响因子: 3.4
• 作者: Tedeschi SK;Ellrodt J;Stratton J;Santacroce L;Chandler PD;Gravallese EM;Solomon DH
• 通讯作者: Solomon DH