HEAL Diversity Supplement: Great Lakes Nodes Clinical Trials Network

项目摘要/摘要 我们评估了移动技术研究心理生理基础的可行性。 影响阿片类药物使用障碍(OUD)。在这项可行性初步研究中，我们将评估 参与者对纵向研究程序的坚持程度，包括：1.穿戴可穿戴设备 研究期间的传感器，2.完成研究活动，包括提示和 自我报告压力和消极情绪的瞬间体验。我们还将 检查两个可穿戴传感器采集的生理数据的有效性和可靠性 从两个不同的品牌，放在不同的身体位置。重要的是要 评估同时来自两台设备的数据的可靠性，以检查可能阻碍 研究的可行性，如数据噪声、信号问题或数据丢失等。最后，我们将利用 研究自主神经功能作为压力和压力的有效生理标志物的作用 OUD中的负面影响。这对理解和发展 数字化治疗，如压力和负面情绪是复发的主要原因。这项试点工作 将通过使用数字和计算健康核心来为父母赠款的目标2做出贡献 推进移动健康、人工智能和机器学习方面的研究。此外，这项工作 本补充资料下提供的支持将作为构建块成功创建和提交 F31拨款提案，这项研究将在多样性补充之后进行 句号。这一补充将支持密集的培训和宝贵的实践经验 这将推动实习生维罗妮卡·拉米雷斯的职业生涯。这与目标6一致。 母公司拨款“扩大早期调查人员的渠道”，并创建项目， 支持“成瘾和药物滥用研究、培训和指导”。与此相一致， 我们的研究最终可以帮助目前解决阿片类药物流行的努力来改善其 对社会的有害影响。

Project Summary/Abstract We assess the feasibility of mobile technologies to study the psychophysiological underpinnings of affect in Opioid Use Disorder (OUD). In this feasibility pilot study, we will evaluate participants’ adherence to the procedures of a longitudinal study, including: 1. wearing wearable sensors for the duration of the study, 2. completing research activities involving prompted and self-initiated self-reports on momentary experiences of stress and negative affect. We will also examine the validity and reliability of the physiological data captured with two wearable sensors from two different brands and that are placed in different body locations. It is important to assess the reliability of data from two devices simultaneously to examine issues that may hinder a study’s viability, like data noise, signal problems, or data loss, etc. Lastly, we will utilize this data to investigate the role of autonomic function as a valid physiological marker of stress and negative affect in OUD. This has relevant implications in the understanding and development of digital treatments, as stress and negative affect are major contributors of relapse. This pilot work will contribute to the aim 2 of the parent grant by using digital and computational health cores to advance research in mHealth, artificial intelligence, and machine learning. In addition, the work supported under this supplement will serve as a building block to successfully create and submit an F31 grant proposal, a research that will be carried out following the diversity supplement period. This supplement will support the intensive training and invaluable practical experience that will advance the career of the trainee, Veronica Ramirez. This is in alignment with aim 6 of the parent grant to “expand the pipeline for early investigators” and create programs that support “addiction and substance misuse research, training, and mentorship”. Aligned with this, our research can ultimately help current efforts to address the opioid epidemic to ameliorate its detrimental effects on society.