The Role of 27-hydroxycholesterol in Breast Cancer: A Population-Based Multiethnic Study

27-羟基胆固醇在乳腺癌中的作用:基于人群的多种族研究

基本信息

  • 批准号:
    10581518
  • 负责人:
  • 金额:
    $ 42.13万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-03-01 至 2025-02-28
  • 项目状态:
    未结题

项目摘要

ABSTRACT Excess overall adiposity (obesity) is one of the most significant risk factors for breast cancer in postmenopausal women and is a key predictor for poor prognosis. Excess central or visceral adiposity, rather than overall or subcutaneous adiposity, is more indicative of abnormal metabolic profiles and is strongly associated with obesity- related outcomes, including breast cancer incidence and prognosis. Postulated mechanisms underlying the association between obesity and post-menopausal breast cancer include higher levels of estradiol, hypercholesterolemia, and inflammation. Laboratory studies established the cholesterol metabolite, 27- hydroxychlolesterol (27HC), as an endogenous selective estrogen receptor modulator capable of promoting breast cancer growth and metastasis. However, epidemiologic data on the role of 27HC in breast cancer incidence and tumor characteristics is lacking, particularly for diverse racial/ethnic populations. Thus, we propose to conduct a large-scale epidemiologic study to examine the associations of 27HC with body fat distribution, breast cancer incidence, and clinicopathologic characteristics among participants of the Multiethnic Cohort (MEC), which includes five major racial/ethnic groups in the U.S.―African Americans, Japanese Americans, Native Hawaiians, Latinos and Whites. In Aim 1, we will examine the association between body fat distribution and circulating levels of 27HC in 913 healthy females and conduct a longitudinal study among a subset of these women (n=796) to examine the association between waist-hip-ratio and circulating levels of 27HC. In Aim 2, we will examine the independent association of circulating levels of 27HC and joint associations of 27HC, estradiol, and lipids with postmenopausal breast cancer incidence (cases/controls=1,572/1,572). In Aim 3, we will examine in breast tumor tissue (n=700) the association between gene expression levels of 27HC-regulating enzymes and clinicopathologic characteristics, including grade, stage, PAM50-defined molecular subtypes, and breast cancer-specific gene expression signatures. The strengths of this proposal include: (1) it represents the first large-scale multiethnic population-based epidemiologic investigation of 27HC and breast cancer; (2) it investigates the possible pathway by which 27HC may impact breast cancer by examining refined measures of body fat distribution in relation to 27HC levels; (3) it examines the relationship between expression of 27HC- regulating enzymes and clinicopathologic characteristics in breast tumors to interrogate the biological mechanisms mediated by 27HC; (4) it leverages the high quality resources within the MEC (e.g. extensive questionnaire information, blood and tumor tissue samples, and >20 years of follow-up data). The findings from this proposal will expand our understanding of the role of the 27HC-estradiol pathway in breast cancer, particularly in regards to different body fat distribution. This knowledge could serve as the basis for personalized breast cancer prevention and treatment strategies across different racial/ethnic populations.
摘要

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Iona C Cheng其他文献

Iona C Cheng的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Iona C Cheng', 18)}}的其他基金

Understanding the impact of structural racism on racial/ethnic inequities in mortality: The Multiethnic Cohort Study
了解结构性种族主义对种族/民族死亡率不平等的影响:多民族队列研究
  • 批准号:
    10531782
  • 财政年份:
    2022
  • 资助金额:
    $ 42.13万
  • 项目类别:
Understanding the role of structural racism on racial/ethnic inequities in lung cancer risk
了解结构性种族主义对种族/民族不平等在肺癌风险中的作用
  • 批准号:
    10450374
  • 财政年份:
    2022
  • 资助金额:
    $ 42.13万
  • 项目类别:
Understanding the impact of structural racism on racial/ethnic inequities in mortality: The Multiethnic Cohort Study
了解结构性种族主义对种族/民族死亡率不平等的影响:多民族队列研究
  • 批准号:
    10709871
  • 财政年份:
    2022
  • 资助金额:
    $ 42.13万
  • 项目类别:
Impact of Climate Change on Life Expectancy in a Multiethnic Population
气候变化对多民族人口预期寿命的影响
  • 批准号:
    10522422
  • 财政年份:
    2022
  • 资助金额:
    $ 42.13万
  • 项目类别:
Understanding the role of structural racism on racial/ethnic inequities in lung cancer risk
了解结构性种族主义对种族/民族不平等在肺癌风险中的作用
  • 批准号:
    10646405
  • 财政年份:
    2022
  • 资助金额:
    $ 42.13万
  • 项目类别:
The Role of 27-hydroxycholesterol in Breast Cancer: A Population-Based Multiethnic Study
27-羟基胆固醇在乳腺癌中的作用:基于人群的多种族研究
  • 批准号:
    10166556
  • 财政年份:
    2020
  • 资助金额:
    $ 42.13万
  • 项目类别:
The Role of 27-hydroxycholesterol in Breast Cancer: A Population-Based Multiethnic Study
27-羟基胆固醇在乳腺癌中的作用:基于人群的多种族研究
  • 批准号:
    10360551
  • 财政年份:
    2019
  • 资助金额:
    $ 42.13万
  • 项目类别:
A cohort study of air pollution, lung cancer, and COPD in Los Angeles County
洛杉矶县空气污染、肺癌和慢性阻塞性肺病的队列研究
  • 批准号:
    9761527
  • 财政年份:
    2017
  • 资助金额:
    $ 42.13万
  • 项目类别:
A cohort study of air pollution, lung cancer, and COPD in Los Angeles County
洛杉矶县空气污染、肺癌和慢性阻塞性肺病的队列研究
  • 批准号:
    9543858
  • 财政年份:
    2017
  • 资助金额:
    $ 42.13万
  • 项目类别:
Mitochondrial Genetic Susceptibility to Breast and Prostate Cancers
线粒体对乳腺癌和前列腺癌的遗传易感性
  • 批准号:
    8444365
  • 财政年份:
    2013
  • 资助金额:
    $ 42.13万
  • 项目类别:

相似海外基金

Contributions of cell behaviours to dorsal closure in Drosophila abdomen
细胞行为对果蝇腹部背侧闭合的贡献
  • 批准号:
    2745747
  • 财政年份:
    2022
  • 资助金额:
    $ 42.13万
  • 项目类别:
    Studentship
Using the GI Tract as a Window to the Autonomic Nervous System in the Thorax and in the Abdomen
使用胃肠道作为胸部和腹部自主神经系统的窗口
  • 批准号:
    10008166
  • 财政年份:
    2018
  • 资助金额:
    $ 42.13万
  • 项目类别:
Development of a free-breathing dynamic contrast-enhanced (DCE)-MRI technique for the abdomen using a machine learning approach
使用机器学习方法开发腹部自由呼吸动态对比增强 (DCE)-MRI 技术
  • 批准号:
    18K18364
  • 财政年份:
    2018
  • 资助金额:
    $ 42.13万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Combined motion-compensated and super-resolution image reconstruction to improve magnetic resonance imaging of the upper abdomen
结合运动补偿和超分辨率图像重建来改善上腹部的磁共振成像
  • 批准号:
    1922800
  • 财政年份:
    2017
  • 资助金额:
    $ 42.13万
  • 项目类别:
    Studentship
Optimising patient specific treatment plans for ultrasound ablative therapies in the abdomen (OptimUS)
优化腹部超声消融治疗的患者特定治疗计划 (OptimUS)
  • 批准号:
    EP/P013309/1
  • 财政年份:
    2017
  • 资助金额:
    $ 42.13万
  • 项目类别:
    Research Grant
Optimising patient specific treatment plans for ultrasound ablative therapies in the abdomen (OptimUS)
优化腹部超声消融治疗的患者特定治疗计划 (OptimUS)
  • 批准号:
    EP/P012434/1
  • 财政年份:
    2017
  • 资助金额:
    $ 42.13万
  • 项目类别:
    Research Grant
Relationship between touching the fetus via the abdomen of pregnant women and fetal attachment based on changes in oxytocin levels
基于催产素水平变化的孕妇腹部触摸胎儿与胎儿附着的关系
  • 批准号:
    16K12096
  • 财政年份:
    2016
  • 资助金额:
    $ 42.13万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Design Research of Healthcare System based on the Suppleness of Upper Abdomen
基于上腹部柔软度的保健系统设计研究
  • 批准号:
    16K00715
  • 财政年份:
    2016
  • 资助金额:
    $ 42.13万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Technical Development of Diffusion Tensor Magnetic Resonance Imaging in the Human Abdomen
人体腹部弥散张量磁共振成像技术进展
  • 批准号:
    453832-2014
  • 财政年份:
    2015
  • 资助金额:
    $ 42.13万
  • 项目类别:
    Postdoctoral Fellowships
Technical Development of Diffusion Tensor Magnetic Resonance Imaging in the Human Abdomen
人体腹部弥散张量磁共振成像技术进展
  • 批准号:
    453832-2014
  • 财政年份:
    2014
  • 资助金额:
    $ 42.13万
  • 项目类别:
    Postdoctoral Fellowships
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了