Training in the Molecular & Genetic Epidemiology of Cancer

摘要 这项提议是为了竞争性地更新分子和遗传学的博士后培训计划 癌症流行病学(MGEC)。当前的癌症研究时代使用了非凡的工具来 了解致癌的遗传和环境原因。使用这些工具来实现其 最大程度地需要来自具有不同背景的科学家团队的投入，包括分子 生物学、肿瘤学、医学、遗传学、流行病学和生物统计学。具有多学科背景的个人 这些领域的教育对这些团队的成功至关重要，因为他们可以协调 完成一些最有希望的研究所需的综合工作。然而，专注于 大多数培训机会的性质为调查人员获取知识提供了有限的机会 这是连接这些学科的桥梁。为了解决这个问题，我们建议更新目前的MGEC培训 将当前的R25T机制编程为T32机制。 该计划为优秀的博士后候选人提供一套指导和研究 为他们在跨学科领域的独立研究人员的职业生涯做好准备的机会 分子和遗传流行病学。导师和研究培训机会将来自 加州大学旧金山分校和加州北部凯撒永久分部 研究。该计划非常适合T32资助机制，因为它在 多个不同字段的交集。更具体地说，MGEC计划融合在一起，形成了高度 互动时尚-一群在分子生物学方面具有癌症研究专长的导师和学员， 遗传学、流行病学和生物统计学。该方案由三个主要组成部分确定：(1)a 涵盖主要学科及其交叉的专业核心课程；(2)额外的教育 补充学员研究、教育背景和兴趣的经验；及(3) 由忠诚的导师监督的重点研究项目。每个实习生还将被要求写下 作为他们职业准备的一部分，NIH提出了一项建议。以前的学员在以下方面取得了巨大的成功 发展独立研究事业。在MGEC计划中接受培训的个人将拥有 对他们进一步研究癌症的原因至关重要，最终提供了 关于预防和治疗这种复杂疾病的宝贵知识。

Abstract This proposal is for a competitive renewal of a post-doctoral training program in Molecular & Genetic Epidemiology of Cancer (MGEC). The current era of cancer research employs extraordinary tools for understanding the genetic and environmental causes of carcinogenesis. Using these tools to their fullest extent requires input from teams of scientists with a variety of backgrounds, including molecular biology, oncology, medicine, genetics, epidemiology, and biostatistics. Individuals with multi-disciplinary education across these fields are crucial to the success of such teams, as they can coordinate the integrated work necessary to accomplish some of the most promising research. However, the focused nature of most training opportunities provides limited opportunities for investigators to obtain knowledge that bridges these disciplines. To address this issue, we propose renewing the current MGEC training program from the current R25T mechanism to a T32 mechanism. This program offers to exceptional postdoctoral candidates a set of instructional and research opportunities that prepare them for careers as independent researchers in the interdisciplinary “field” of molecular and genetic epidemiology. Mentors and research training opportunities will come from the University of California, San Francisco and the Kaiser Permanente Northern California Division of Research. This program is well-suited to the T32 grant mechanism because it trains scientists at the intersection of multiple distinct fields. More specifically, the MGEC program blends together in a highly interactive fashion a group of mentors and trainees with cancer research expertise in molecular biology, genetics, epidemiology, and biostatistics. The program is defined by three main components: (1) a specialized core curriculum covering key disciplines and their intersections; (2) additional educational experiences to complement the research and educational backgrounds and interest of trainees; and (3) focused research projects supervised by committed mentors. Each trainee will also be required to write an NIH proposal as part of their career preparation. Previous trainees have shown great success in developing independent research careers. Individuals trained in the MGEC program will have the skills vital to furthering their careers in research to decipher the causes of cancer, ultimately providing valuable knowledge regarding the prevention and treatment of this complex disease.