Sleep, Pain, Active Social Life, and Inflammation (SPAI)

睡眠、疼痛、活跃的社交生活和炎症 (SPAI)

• 批准号: 10585655
• 负责人: Soomi Lee
• 金额: $ 51.38万
• 依托单位: UNIVERSITY OF SOUTH FLORIDA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-20 至 2023-08-07
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10585655
• 关键词: Adult; Affect; Affective; Back Pain; Behavior; Behavior Therapy; Behavioral; Behavioral Mechanisms; Biological; Black race; Characteristics; Clinical; Cohort Studies; Degenerative polyarthritis; Development; Dimensions; Elderly; Family; Frequencies; Friends; Funding; Future; Health; Health behavior; Healthcare Systems; Individual; Inflammation; Inflammatory; Influentials; Intervention; Joints; Life; Life Style; Link; Measures; Mediating; Mediator; Mental Health; Mission; Multicenter Studies; Outcome; Pain; Pain Threshold; Pain interference; Pain management; Pathway interactions; Patient Self-Report; Pharmaceutical Preparations; Polysomnography; Population; Prognostic Marker; Public Health; Quality of life; Race; Reporting; Research; Risk; Risk Factors; Sampling; Sensory; Severities; Sleep; Sleep Disorders; Sleep disturbances; Subgroup; Time; United States; United States National Institutes of Health; Visit; Withdrawal; Woman; actigraphy; alertness; chronic pain; chronic painful condition; cohort; experience; functional disability; high risk; improved; inflammatory pain; insight; knee pain; meetings; middle age; neural circuit; older men; pain outcome; pain perception; physical conditioning; poor sleep; satisfaction; sex; sleep health; sleep pattern; sleep quality; social; social disparities; social engagement; sociodemographics; systemic inflammatory response; volunteer

Abstract Chronic pain is a prognostic marker of illness and imposes a substantial burden on the healthcare system, affecting approximately 20-30% of US adults. Sleep problems commonly co-occur with chronic pain, yet little is known of how sleep impacts chronic pain. Social engagement and inflammation have relationships with both sleep and chronic pain, but no study has examined these behavioral and biological mechanisms underlying the impact of sleep on chronic pain. This R01 initiates a multi-cohort study to examine the extent to which the impact of sleep on chronic pain is mediated by social lifestyles and inflammation. In this study, we take a sleep health perspective to capture multiple sleep characteristics critical to chronic pain (regularity, satisfaction, alertness, timing, efficiency, and duration). Based on multiple sleep variables captured by self-report, actigraphy, and/or polysomnography, we will identify “sleep health profiles” (the composite number of sleep problems or latent groups with similar sleep characteristics across multiple dimensions) and link them to chronic pain outcomes. Our sleep profile approach has advantages because it can consider multiple sleep problems that may co-occur within individuals, and may differentially impact pain outcomes. Leveraging three NIH-funded projects (Midlife in the United States Study-MIDUS, Outcomes of Sleep Disorders in Older Men-MrOS, and Multicenter Osteoarthritis Study-MOST), we examine multiple common chronic pain conditions prevalent in adult populations (any chronic pain, back pain, and knee pain) and their multiple manifestations (frequency, severity, and sensitization). This can help determine whether the associations between sleep health profiles and chronic pain emerge across different pain conditions. Aim 1 will examine the longitudinal impact of sleep health profiles on subsequent changes in pain for three separate pain outcomes. We hypothesize that poor sleep health profiles are associated with: [MIDUS] new onset of any chronic pain and/or an increase in pain interference among midlife and older adults; [MrOS] new onset of back pain and/or increases in the frequency and severity of back pain among older men; [MOST] increases in knee pain severity and clinical sensitization among older men/women with the risk of osteoarthritis over time. Aim 2 will examine behavioral and biological mechanisms underlying the impact of sleep health profiles on changes in pain. We hypothesize that poor sleep health profiles are associated with more chronic pain over time mediated by lower diversity in social activities (i.e., a less active social life) or by a higher risk of systemic inflammation. Aim 3 will examine independent and joint effects of behavioral and biological mechanisms underlying the impact of sleep health profiles on changes in pain. Our multi-cohort approach also allows us to detect potential social disparities in sleep and chronic pain by aggregating relevant racial and sex sub-groups across cohorts. This project will inform future behavioral interventions (e.g., sleep health intervention) to improve chronic pain in adults by identifying specific sleep characteristics, and key behavioral and biological mechanisms linking sleep health and chronic pain.

摘要 慢性疼痛是疾病的一个预后标志，并给医疗系统带来了巨大的负担， 影响大约20%-30%的美国成年人。睡眠问题通常与慢性疼痛并存，但很少有 知道睡眠如何影响慢性疼痛。社会参与和炎症与这两种疾病都有关系 睡眠和慢性疼痛，但还没有研究检查这些行为和生物学机制背后的 睡眠对慢性疼痛的影响。R01启动了一项多队列研究，以检查影响的程度 睡眠对慢性疼痛的影响受到社会生活方式和炎症的影响。在这项研究中，我们采取了睡眠健康 捕捉对慢性疼痛至关重要的多种睡眠特征(规律性、满足感、警觉性、 时间、效率和持续时间)。基于自我报告、活动记录和/或捕获的多个睡眠变量 多导睡眠图，我们将确定“睡眠健康档案”(睡眠问题或潜在的综合数量 在多个维度上具有相似睡眠特征的人群)，并将其与慢性疼痛结果联系起来。 我们的睡眠概况方法具有优势，因为它可以考虑可能同时发生的多个睡眠问题 在个人内部，可能会对疼痛结果产生不同的影响。利用美国国立卫生研究院资助的三个项目(Midlife 在美国的MIDUS研究中，老年男性睡眠障碍的结果-MRO和多中心 骨关节炎研究-MOST)，我们检查了成人人群中普遍存在的多种常见慢性疼痛情况 (任何慢性疼痛、背痛和膝痛)及其多种表现(频率、严重程度和 敏化)。这有助于确定睡眠健康状况和慢性疼痛之间的关联 会跨越不同的疼痛状况。目标1将检查睡眠健康概况对以下方面的纵向影响 随后的三种不同疼痛结果的疼痛变化。我们假设糟糕的睡眠健康状况 与：[MIDUS]任何慢性疼痛的新发作和/或以下人群中疼痛干扰的增加有关 中年和老年人；[MROS]新的背部疼痛和/或背部频率和严重程度的增加 老年男性的疼痛；[大多数]老年人膝关节疼痛严重程度和临床敏感度的增加 随着时间的推移，有骨关节炎风险的男性/女性。目标2将检查行为和生物机制 睡眠健康状况对疼痛变化的影响。我们假设糟糕的睡眠健康状况 随着时间的推移，社交活动的多样性较低(即不太活跃)，与更多的慢性疼痛有关 社交生活)或更高的全身炎症风险。目标3将考察以下因素的独立和联合影响 睡眠健康状况对疼痛变化影响的行为和生物学机制。我们的 多队列方法还允许我们通过汇总以下数据来发现睡眠和慢性疼痛方面的潜在社会差异 各队列中相关的种族和性别子群体。该项目将为未来的行为干预提供信息(例如， 睡眠健康干预)通过确定特定的睡眠特征和关键 将睡眠健康和慢性疼痛联系起来的行为和生物机制。