Tai Chi Practice and Sleep-Active Glymphatic Function
太极拳练习和睡眠活跃类淋巴功能
基本信息
- 批准号:10583904
- 负责人:
- 金额:$ 49.38万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-01-01 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:Abeta clearanceAbeta synthesisAffectiveAlzheimer disease preventionAlzheimer&aposs DiseaseAlzheimer&aposs disease modelAlzheimer&aposs disease pathologyAlzheimer&aposs disease related dementiaAlzheimer’s disease biomarkerAmyloid beta-ProteinBedsBehaviorBiological MarkersBlood VesselsBrainBreathingCardiovascular PhysiologyCerebrospinal FluidCerebrovascular DisordersChineseChronicClinicalClinical ResearchClinical TrialsCognitionCognitiveDementiaDepositionDevelopmentDiseaseElderlyEnrollmentEquilibriumFailureFoundationsFrequenciesFunctional Magnetic Resonance ImagingFutureGoalsHumanIndividualIntercellular FluidInterventionIntervention TrialLongitudinal StudiesMagnetic Resonance ImagingMeasurableMeasurementMeasuresModalityMoodsMotionMovementOutcomeParticipantPathologicPathway interactionsPatient Self-ReportPhysical activityPhysiologicalPhysiological ProcessesPilot ProjectsPolysomnographyPosturePreventionPrimary PreventionProteinsQuestionnairesRespirationRespiratory physiologyRiskSelf AssessmentSenile PlaquesSleepSleep Apnea SyndromesSleep FragmentationsSleep disturbancesSymptomsTai JiTestingTrainingVasomotorVentricularVeteransWaterWell in selfaging brainblood oxygen level dependentcerebrospinal fluid flowcontrast enhancedcostdementedexperienceglymphatic clearanceglymphatic dysfunctionglymphatic functionglymphatic systemimprovedimprovement on sleepinterestinterstitialmiddle agemindfulnessmouse modelmultimodalitynovel strategiespressurepreventprospectiverandomized, clinical trialsrecruitresponsesecondary analysissleep qualitysolutestudy populationtau Proteinswasting
项目摘要
PROJECT SUMMARY/ABSTRACT
Amyloid plaque deposition, a key pathological hallmark of Alzheimer’s disease (AD), begins 1-2 decades
before manifestation of clinical symptoms of dementia. Among cognitively intact individuals and in AD’s most
prevalent sporadic form, the production of amyloid-β (Aβ) does not change, while clearance of Aβ is slowed,
indicating that the failure of Aβ clearance may underlie the development of AD pathology and that interventions
that improve its clearance may provide an opportunity for primary prevention of AD. Over the past 10 years,
our group has helped to define the ‘glymphatic system’, a brain-wide network of perivascular pathways along
which cerebrospinal fluid (CSF) surrounding the brain exchanges with brain interstitial fluid, supporting the
clearance of interstitial wastes, including Aβ and tau. Impairment of glymphatic clearance is observed in the
aging brain and in mouse models of AD. Thus, improving glymphatic clearance of brain interstitial proteins may
be one approach to preventing the development of AD. Glymphatic function is regulated by sleep-wake
behavior, with faster clearance occurring during sleep. Tai Chi is a Chinese martial art focusing on mindful
body movement, posture, and breathing as an avenue to achieve a state of internal balance, calm, and clarity.
In clinical studies, practice of Tai Chi is associated with improved sleep quality, cognition, mood,
cardiovascular and respiratory function, and balance/physical activity. However, the physiological processes
underlying the cognitive and affective effects of Tai Chi remain undefined. We hypothesize that Tai Chi practice
improves glymphatic function. To test this hypothesis, we will enroll 75 middle-aged (50-70 years) participants
with different levels of Tai Chi practice experience: Tai Chi proficients (10+ year of practice, n=25), Tai Chi
beginners (12 months practice, n=25) and Tai Chi naïve participants (n=25). We will 1) examine the
association between Tai Chi practice and glymphatic function using multi-modal magnetic resonance imaging
(MRI) using contrast-enhanced MRI, T1/FLAIR assessment of MRI-visible perivascular spaces, intravoxel
incoherent motion, and fast BOLD-fMRI; 2) examine relationships between Tai Chi practice and sleep,
including sleep fragmentation, efficiency, and duration, assessed by self-reported questionnaires and objective
measurements of sleep duration, fragmentation and efficiency using a bed pressure mat. We will examine the
relationship between sleep measures and MRI-assessed glymphatic function. The ultimate goal of this study is
to elucidate mechanisms of Tai Chi practice in prevention of AD and related dementias. This pilot study will
determine whether long-term Tai Chi practice is associated with physiological changes in glymphatic function
and sleep. If we find cross-sectional association among Tai Chi practice, glymphatic function, and sleep, in the
future we will investigate whether these changes are associated with duration of Tai Chi practice and whether
these changes are associated with changes in AD biomarkers in a longitudinal study or in a prospective
randomized clinical trial.
项目总结/摘要
淀粉样斑块沉积是阿尔茨海默病(AD)的一个关键病理标志,
在痴呆临床症状出现之前。在认知完整的个体中,
散发型,β淀粉样蛋白(Aβ)的产生没有变化,而Aβ的清除减慢,
表明Aβ清除的失败可能是AD病理学发展的基础,
提高其清除率可能为AD的一级预防提供机会。在过去的10年里,
我们的小组帮助定义了“胶质淋巴系统”,一个由血管周围通路组成的全脑网络沿着
其中脑周围的脑脊液(CSF)与脑间质液交换,支持脑内的
清除间质废物,包括Aβ和tau。胶质淋巴清除的损害是观察到的
老化的大脑和AD的小鼠模型。因此,改善脑间质蛋白的胶质淋巴清除可能
是预防AD发展的一种方法。淋巴功能受睡眠-觉醒调节
行为,在睡眠期间发生更快的清除。太极是一种专注于意念的中国武术
身体运动,姿势和呼吸作为达到内部平衡,平静和清晰状态的途径。
在临床研究中,太极拳的练习与改善睡眠质量,认知,情绪,
心血管和呼吸功能以及平衡/体力活动。然而,生理过程
太极的认知和情感影响的基础仍然不明确。我们假设太极拳练习
改善胶质淋巴功能。为了验证这一假设,我们将招募75名中年(50-70岁)参与者
具有不同太极拳练习经验水平:太极拳熟练者(10年以上练习,n=25),太极拳
初学者(12个月的练习,n=25)和太极天真的参与者(n=25)。我们将1)检查
多模态磁共振成像研究太极拳练习与淋巴功能之间的关系
(MRI)使用对比增强MRI,MRI可见血管周围间隙的T1/FLAIR评估,体素内
不连贯的运动,和快速BOLD-fMRI; 2)研究太极练习和睡眠之间的关系,
包括睡眠碎片,效率和持续时间,通过自我报告的问卷和客观评估
使用床压垫测量睡眠持续时间、碎片和效率。我们会研究
睡眠测量和MRI评估的胶质淋巴功能之间的关系。本研究的最终目的是
阐明太极拳练习预防AD及相关痴呆的机制。这项试点研究将
确定长期太极练习是否与淋巴功能的生理变化有关
睡觉如果我们发现太极拳练习,胶质淋巴功能和睡眠之间的横截面联系,
未来,我们将调查这些变化是否与太极拳练习的持续时间有关,
这些变化与纵向研究或前瞻性研究中AD生物标志物的变化相关。
随机临床试验。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jeffrey J Iliff其他文献
Jeffrey J Iliff的其他文献
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{{ truncateString('Jeffrey J Iliff', 18)}}的其他基金
The role of post-traumatic sleep-wake disruption in the development of tau pathology following mild traumatic brain injury
创伤后睡眠觉醒中断在轻度创伤性脑损伤后 tau 病理学发展中的作用
- 批准号:
10588916 - 财政年份:2023
- 资助金额:
$ 49.38万 - 项目类别:
Role of Sleep Disruption after mTBI as a Driver of Chronic Post-traumatic Headache
mTBI 后睡眠中断是慢性创伤后头痛的驱动因素
- 批准号:
10736602 - 财政年份:2023
- 资助金额:
$ 49.38万 - 项目类别:
Defining the role of age-related glymphatic pathway impairment in amyloid beta plaque deposition
定义年龄相关的类淋巴通路损伤在淀粉样β斑块沉积中的作用
- 批准号:
10198706 - 财政年份:2017
- 资助金额:
$ 49.38万 - 项目类别:
Defining the role of age-related glymphatic pathway impairment in amyloid beta plaque deposition
定义年龄相关的类淋巴通路损伤在淀粉样β斑块沉积中的作用
- 批准号:
10003575 - 财政年份:2017
- 资助金额:
$ 49.38万 - 项目类别:
Defining the role of age-related glymphatic pathway impairment in amyloid beta plaque deposition
定义年龄相关的类淋巴通路损伤在淀粉样β斑块沉积中的作用
- 批准号:
9214181 - 财政年份:2017
- 资助金额:
$ 49.38万 - 项目类别:
Role of perivascular aquaporin-4 polarization in post-traumatic neurodegeneration
血管周围水通道蛋白 4 极化在创伤后神经变性中的作用
- 批准号:
9309096 - 财政年份:2015
- 资助金额:
$ 49.38万 - 项目类别: