Research Education Component

研究教育部分

• 批准号: 10433874
• 负责人: Jeffrey J Iliff
• 金额: $ 11.25万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10433874
• 关键词: Address; Aging; Alaska Native; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American Indians; Animal Model; Award; Basic Science; Big Data; Bioinformatics; Biological; Brain; Clinic; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communities; Community Developments; Competence; Correlation Studies; Data; Data Set; Dementia; Development; Disease; Ecosystem; Educational Curriculum; Educational workshop; Environment; Etiology; Faculty; Focus Groups; Fostering; Foundations; Funding; Future; Genetic; Goals; Grant; Home; Human; Image; Individual; Institutes; Interest Group; Knowledge; Knowledge Portal; Medicine; Memory Loss; Mentors; Mentorship; Minority; Native Americans; Native Hawaiian or Other Pacific Islander; Nerve Degeneration; Neurosciences; Participant; Pathologic; Population; Positioning Attribute; Postdoctoral Fellow; Prevention; Research; Research Personnel; Research Project Grants; Research Support; Resources; Scientist; Series; Structure; Technical Expertise; Time; Training; Translating; Translational Research; Travel; Universities; Washington; base; biological heterogeneity; career; data resource; data sharing; education research; imaging biomarker; improved; innovation; interdisciplinary approach; literacy; meetings; multidisciplinary; neurobehavior; neuropathology; outreach; pre-doctoral; programs; ranpirnase; research and development; tool; transcriptomics; working group

Abstract Research into the causes, presentation, prevention and treatment of Alzheimer's disease and related dementias (ADRD) increasingly demands a team-based multi-disciplinary approach that includes clinicians, clinical and basic science researchers. The goal of the University of Washington Alzheimer's Disease Research Center Research Education Component (UW ADRC REC) is to foster the development of a thriving, innovative and diverse ADRD research community that is able to define the varied biological and mechanistic drivers of ADRD. The UW ADRC REC will first provide a one year broad-based curriculum to REC Trainees, including basic, translational and clinical research trainees, in order to establish a common understanding of the clinical presentation of ADRD as they are ere encountered in the clinic and studied in the lab. Support for the widespread use of teleconferencing at training sessions and UW ADRC meetings will provide access to this dynamic clinical and research environment to ADRD investigators studying aging and ADRD in American Native communities and populations. The UW ADRC REC will second provide support to REC Investigators new to the UW ADRC or entering the ADRD research field for the first time in accessing and interacting with the vast array of expertise, data and resources available within the UW ADRC ecosystem. This support is explicitly targeted to include young investigators whose developing research programs will form the pipeline for research utilizing resources and data generated by the UW ADRC in the future. Last, the UW ADRC REC will seek to fill a critical gap in training and expertise in the use of publicly available ADRD-related `big data' throughout the national ADRD research community. Through its partnership with Seattle-based Sage Bionetworks, it will establish and support an annual two-day ADRD Open Neuroscience Workshop that will help ADRD-focused trainees and investigators develop proficiency with publicly-available datasets, their origins and structures, their user interfaces, and statistical and computational approaches to their use. These workshops will be open to individuals at the UW ADRC and other ADRCs nationally. Through ongoing collaborations Sage Bionetworks, it will further support the seeding and support of mentored Open Neuroscience working groups focused on developing new research projects based on these data. This will include the progressive use of integrated clinical, neuropsychometric, imaging and biomarker, genetic and pathological data generated throughout the UW ADRC in these ADRD Open Neuroscience Workshops.

摘要 研究阿尔茨海默病的病因、表现、预防和治疗以及相关的 痴呆症（ADRD）越来越需要一种基于团队的多学科方法，包括临床医生， 临床和基础科学研究人员。华盛顿大学阿尔茨海默病研究所的目标是 研究中心研究教育组件（UW ADRC REC）是为了促进一个蓬勃发展， 创新和多样化的ADRD研究社区，能够定义各种生物和机械 ADRD的驱动程序UW ADRC REC将首先为REC学员提供为期一年的基础广泛的课程， 包括基础、转化和临床研究培训生，以建立对以下方面的共同理解： ADRD的临床表现，因为他们是在临床上遇到的，并在实验室研究。支持 在培训课程和华盛顿大学ADRC会议上广泛使用电话会议， 这一动态的临床和研究环境，ADRD研究人员研究老化和ADRD在美国 土著社区和人口。UW ADRC REC将第二次为REC调查人员提供支持 新的UW ADRC或进入ADRD研究领域的第一次访问和互动 UW ADRC生态系统中可用的大量专业知识，数据和资源。这种支持是 明确的目标是包括年轻的研究人员，他们的发展研究计划将形成管道， 利用UW ADRC未来产生的资源和数据进行研究。最后，UW ADRC REC将 寻求填补在使用公开可用的与药品不良反应有关的“大数据”方面的培训和专业知识方面的关键空白 在全国ADRD研究界。通过与总部位于西雅图的Sage的合作， Bionetworks将建立和支持每年为期两天的ADRD开放神经科学研讨会， 帮助关注ADRD的学员和研究人员熟练掌握公开的数据集， 和结构，它们的用户界面，以及它们的使用的统计和计算方法。这些 研讨会将在UW ADRC和全国其他ADRC向个人开放。通过持续 合作Sage Bionetworks，它将进一步支持种子和支持指导开放 神经科学工作组专注于根据这些数据开发新的研究项目。这将 包括逐步使用综合临床，神经心理测量，成像和生物标志物，遗传和 在这些ADRD开放神经科学研讨会中，整个UW ADRC产生的病理数据。