Injectable Hydrogel Electrodes to Prevent Ventricular Arrhythmias

可注射水凝胶电极预防室性心律失常

基本信息

项目摘要

Injectable Hydrogel Electrodes to Prevent Ventricular Arrhythmias In the United States, sudden cardiac death accounts for 350,000 deaths per year with the leading cause being lethal ventricular arrhythmias. The underlying electrophysiologic derangement mechanistically responsible for ventricular arrhythmias is delayed conduction velocity in scarred or otherwise diseased myocardium. Access to the smaller vessels and tributaries that cross over scarred region of the heart could provide improved pacing; however, there are no pacing leads small enough to navigate these smaller tributaries. In this research, we propose a novel method to treat and manage ventriculararrhythmias – developmentof a newconductive material that can fill both large and small coronary vessels and convert these tributaries into flexible electrodes to restore capture across regions of scarring. Our collaborative team that combines clinical expertise (Razavi) and biomaterial science (Cosgriff-Hernandez) has demonstrated early feasibility of pacing myocardium with an in situ curing hydrogel in a pig model. We plan to build on this initial proof of concept to develop a combined material and delivery system that can interface with existing pacemaker technology to greatly expand their capability to treat ventricular arrhythmias. Upon successful completion of these aims, we will have utilized a battery of in vitro and in vivo tests to establish the safety and efficacy of this new injectable hydrogel electrode. Confirmation of increased activation area as compared to standard-of-care single point pacing will validate the efficacy of this innovative approach to eliminate the conduction delay in scarred myocardium that results in lethal ventricular arrhythmias. We will use a post-myocardial infarct model to demonstrate that hydrogel electrode pacing reduces the frequency of ventricular arrhythmias and defibrillation shocks. Painless stimulation of wide areas of the heart using planar wavefront propagation from these hydrogel electrodes provides a new cardiac resynchronization therapy that will alter the landscape of cardiac rhythm management.
注射水凝胶电极预防室性心律失常

项目成果

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Elizabeth Marie Cosgriff-Hernandez其他文献

Elizabeth Marie Cosgriff-Hernandez的其他文献

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{{ truncateString('Elizabeth Marie Cosgriff-Hernandez', 18)}}的其他基金

Resorbable, Shape Memory Stents to Prevent Vaginal Fibrosis
可吸收的形状记忆支架可预防阴道纤维化
  • 批准号:
    10301291
  • 财政年份:
    2021
  • 资助金额:
    $ 56.19万
  • 项目类别:
Resorbable, Shape Memory Stents to Prevent Vaginal Fibrosis
可吸收的形状记忆支架可预防阴道纤维化
  • 批准号:
    10454348
  • 财政年份:
    2021
  • 资助金额:
    $ 56.19万
  • 项目类别:
In situ BMSC Seeding of 3D Printed Scaffolds Using Cell-releasing Hydrogels
使用细胞释放水凝胶对 3D 打印支架进行原位 BMSC 接种
  • 批准号:
    10030953
  • 财政年份:
    2020
  • 资助金额:
    $ 56.19万
  • 项目类别:
In situ BMSC Seeding of 3D Printed Scaffolds Using Cell-releasing Hydrogels
使用细胞释放水凝胶对 3D 打印支架进行原位 BMSC 接种
  • 批准号:
    10210190
  • 财政年份:
    2020
  • 资助金额:
    $ 56.19万
  • 项目类别:
EFFECT OF IMPROVED GRAFT COMPLIANCE MATCHING ON INTIMAL HYPERPLASIA
改善移植物顺应性匹配对内膜增生的影响
  • 批准号:
    8954134
  • 财政年份:
    2015
  • 资助金额:
    $ 56.19万
  • 项目类别:
DEVELOPMENT OF PICKERING EMULSIONS AS INJECTABLE BONE GRAFTS
作为可注射骨移植物的 Pickering 乳液的开发
  • 批准号:
    8581393
  • 财政年份:
    2013
  • 资助金额:
    $ 56.19万
  • 项目类别:
MULTILAYER VASCULAR GRAFTS BASED ON COLLAGEN-MIMETIC HYDROGELS
基于仿胶原水凝胶的多层血管移植物
  • 批准号:
    8447429
  • 财政年份:
    2012
  • 资助金额:
    $ 56.19万
  • 项目类别:
MULTILAYER VASCULAR GRAFTS BASED ON COLLAGEN-MIMETIC HYDROGELS
基于仿胶原水凝胶的多层血管移植物
  • 批准号:
    8604392
  • 财政年份:
    2012
  • 资助金额:
    $ 56.19万
  • 项目类别:
MULTILAYER VASCULAR GRAFTS BASED ON COLLAGEN-MIMETIC HYDROGELS
基于仿胶原水凝胶的多层血管移植物
  • 批准号:
    8302864
  • 财政年份:
    2012
  • 资助金额:
    $ 56.19万
  • 项目类别:
Injectable, High Porosity Bone Scaffolds by Emulsion Templating
通过乳液模板法制备可注射的高孔隙率骨支架
  • 批准号:
    7990644
  • 财政年份:
    2010
  • 资助金额:
    $ 56.19万
  • 项目类别:

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