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Microbial and Phage Cultivation Core

微生物和噬菌体培养核心

基本信息

批准号：
10583460
负责人：
ROBERT A BRITTON
金额：
$ 38.24万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-03-01 至 2026-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10583460
关键词：
Animal Disease Models Anti-Bacterial Agents Antibiotic Resistance Bacteria Bacterial Antibiotic Resistance Bacteriophages Clostridium difficile Collection Communities Complex Dedications Disease ESKAPE pathogens Etiology Evolution Faculty Foundations Generations Genes Genome Genomics Goals Health Homeostasis Human Human Microbiome Human Resources Human body Individual Infrastructure Intestines Investments Laboratories Libraries Lytic Medicine Metagenomics Microbe Mission Mucous Membrane Nature Nose Organoids Pathogenicity Production Reagent Research Resources Role Scientist Sequence Analysis Services Site Surface Therapeutic Vagina Viral atmospheric conditions college combat cost data integration deep sequencing gene function human model innovation metagenome metagenomic sequencing microbial microbial community microbial genome microbiome microbiome alteration microbiome research novel pathogen pathogenic bacteria resilience tool translational study

项目摘要

PROJECT SUMMARY The overall goal of the BCM-CARBIRU is to explore non-antibiotic therapeutic approaches to combating antibiotic resistant bacterial pathogens that are deemed urgent and serious threats. To meet this goal, the establishment of the Microbial and Phage Cultivation (MPC) core will provide to the projects the ability to cultivate bacteria and phage in multiple formats and under different atmospheric conditions. The core will also provide sequencing support of newly identified bacteria and phage that emerge from each of the three projects. The MPC organized around three primary objectives. Objective 1. Cultivation of complex microbial communities and individual microbes. Objective 2. Isolation and optimization of bacteriophage for AMR pathogens. Objective 3. Sequencing of individual microbes, phage and complex microbial communities. Centralization of these objectives into the MPC core will reduce costs by allowing all of the projects access to the infrastructure (such as anaerobic and microoxic chambers), bulk purchasing of reagents, and the reduction in labor costs by having dedicated technicians to assist in generation of bacteria and phage. The MPC will facilitate the transfer of expertise in microbial and phage cultivation from the core to trainees from all three projects. Finally, a centralized resource for sequencing of bacteria and phage will allow more coordination between the projects in regard to genomic analysis and data integration. The MPC will be an essential part of the BCM-CARBIRU that, along with the Organoid Cultivation Core, will help achieve the overall goals proposed.

项目总结