Sensitivity to Cannabis Effects and Cue Reactivity as Markers of a Developing Disorder in Adolescents

对大麻效应的敏感性和提示反应性作为青少年发育障碍的标志

• 批准号: 10586397
• 负责人: Hayley Treloar Padovano
• 金额: $ 66.29万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-15 至 2028-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10586397
• 关键词: Acceleration; Accounting; Acute; Address; Adolescence; Adolescent; Affect; Age; Behavioral; Blood Pressure; Brain; Cannabis; Cellular Phone; Clinical; Cues; DSM-V; Data; Development; Dimensions; Disease; Drug usage; Ecological momentary assessment; Environment; Etiology; Formulation; Goals; Growth; Health; Heart Rate; Human; Hypersensitivity; Incubated; Individual; Individual Differences; Inhalation; Intoxication; Laboratories; Life; Longitudinal Studies; Measurable; Measurement; Measures; Modeling; Monitor; National Institute of Drug Abuse; Oils; Oral; Pattern; Pharmaceutical Preparations; Physiological; Predisposition; Process; Protocols documentation; Public Health; Reaction; Reporting; Research; Rewards; Risk; Science; Severities; Societies; Standardization; Statutes and Laws; Symptoms; System; Teenagers; Testing; Time; age effect; age related; biological sex; cannabis administration; cannabis craving; cannabis cue; cohort; craving; cue reactivity; design; drug reward; epidemiology study; incentive salience; indexing; innovation; longitudinal design; marijuana use; marijuana use disorder; motivational processes; neural; pleasure; preclinical study; prevent; preventive intervention; prospective; prospective test; public health priorities; public health relevance; recruit; response; theories; trend

PROJECT SUMMARY Cannabis use disorder (CUD) is a significant public health concern with origins in adolescence. Cannabis use escalates during the teenage years, and early cannabis use predicts the development of later problems. Leading etiological theories suggest that repeated cannabis use as the brain develops produces changes in reward systems. Over time, these instrumental brain changes alter cannabis effects and increase the incentive salience of cannabis cues, ultimately conferring risk for CUD. This longitudinal study pairs ecological momentary assessment (EMA) in the natural environment and a gold-standard human laboratory (HLAB) paradigm to monitor changes in subjective cannabis effects, cue reactivity, and CUD symptoms across the formative adolescent years. Leveraging smartphone (EMA) reports in natural settings allows for studying adolescents’ reactions to the typically higher potency THC products and varied formulations (e.g., oils, edibles) favored by teenagers. The use of an accelerated longitudinal design allows for charting development from ages 13 to 19 through multicohort assessments completed in a shorter timeframe. We aim to recruit 224 adolescents (ages 13 to 16 at study outset, n = 56 per age cohort) who endorse cannabis use in the past month. Adolescents will complete a baseline HLAB protocol with follow-ups at 1, 2, and 3 years. Each yearly assessment point will also include a 28-day measurement burst of EMA in daily life. Multiple domain latent growth curve modeling will: (Aim 1) characterize age-related changes in sensitivity to rewarding cannabis effects over adolescence (ages 13 to 19); (Aim 2) test prospective relations of CUD symptom progression with change in sensitivity to rewarding cannabis effects; and (Aim 3) test prospective relations of CUD progression with responses to cannabis cues in the natural environment and HLAB. The proposed longitudinal study extends the investigative team’s prior research showing cross-sectional associations of CUD severity with subjective cannabis effects and cue reactivity among adolescents. Our proposal is highly innovative, as well-studied etiological CUD constructs are assessed across adolescence in real-world and laboratory settings using well-operationalized, multidimensional assessments. Further, disaggregating individual differences in change from overall age trends through an accelerated longitudinal design is a sensitive approach that is distinctively innovative. Our proposal addresses a key priority identified by the NIDA Epidemiology Research Branch by efficiently combining the advantages of longitudinal research with behavioral and laboratory-based measures to inform understanding of CUD etiology (NOT-DA-19-066). This proposal will support efforts to prevent the progression of an incubating or emerging CUD by enhancing scientific understanding of the trajectory to more severe harms. Providing new empirical evidence of malleable processes that can serve as targets of preventative interventions has power to reduce the magnitude of societal ramifications of CUD.

项目概要 大麻使用障碍（CUD）是一个重要的公共卫生问题，起源于青春期。大麻的使用 在青少年时期，这种情况会升级，早期使用大麻预示着以后问题的发展。领导 病因学理论表明，随着大脑的发育，重复使用大麻会产生奖励的变化 系统。随着时间的推移，这些工具性的大脑变化会改变大麻的效果并增加激励的显着性 大麻线索，最终带来 CUD 风险。这项纵向研究将生态瞬时 自然环境中的评估（EMA）和黄金标准人类实验室（HLAB）范例 监测整个形成过程中主观大麻效应、提示反应性和 CUD 症状的变化 青少年时期。在自然环境中利用智能手机 (EMA) 报告可以研究青少年的 对通常效力较高的 THC 产品和各种配方（例如油、食品）的反应 青少年。使用加速纵向设计可以绘制 13 至 19 岁的发展图表 通过在更短的时间内完成的多队列评估。我们的目标是招募 224 名青少年（13 岁） 在研究开始时有 16 名（每个年龄组 n = 56 名）在过去一个月内支持使用大麻。青少年会 完成基线 HLAB 方案并在 1 年、2 年和 3 年进行随访。每个年度考核点还将 包括日常生活中 28 天的 EMA 突发测量。多域潜在增长曲线建模将：（目标 1）描述青春期（13岁至 19); （目标 2）测试 CUD 症状进展与奖励敏感性变化的前瞻性关系 大麻的影响； （目标 3）测试 CUD 进展与大麻线索反应的前瞻性关系 自然环境和 HLAB。拟议的纵向研究扩展了调查小组之前的研究 研究显示 CUD 严重程度与主观大麻效应和线索的横断面关联 青少年之间的反应。我们的建议具有高度创新性，因为经过充分研究的病因学 CUD 结构 使用操作良好的多维方法在现实世界和实验室环境中对青春期进行评估 评估。此外，通过 加速纵向设计是一种具有独特创新性的敏感方法。我们的建议解决了 NIDA 流行病学研究分会通过有效结合各领域的优势确定了重点优先事项 通过基于行为和实验室测量的纵向研究来了解 CUD 病因学 （不是-DA-19-066）。该提案将支持防止正在孵化或正在出现的疾病进展的努力 CUD 通过加强对更严重危害轨迹的科学理解。提供新的经验 可以作为预防性干预目标的可延展过程的证据有能力减少 CUD 的社会影响程度。