Novel Approaches to Understanding How Alcohol Pathology Develops in Adolescents

了解青少年酒精病理学如何发展的新方法

• 批准号: 10092877
• 负责人: Hayley Treloar Padovano
• 金额: $ 19.45万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10092877
• 关键词: Active Learning; Address; Adolescence; Adolescent; Adolescent Development; Adult; Affect; Affective; Age; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcoholism; Alcohols; Animals; Area; Award; Blinking; Blood Pressure; Blood alcohol level measurement; Brain; Clinical; Clinical Research; Cognitive; Complex; Cross-Sectional Studies; Cues; Data; Data Set; Depressed mood; Desire for food; Development; Early Intervention; Ecological momentary assessment; Electromyography; Elements; Emotional; Emotions; Enrollment; Environment; Ethics; Etiology; Feeling; Foundations; Funding; Goals; Happiness; Heart Rate; Human; Impairment; Incentives; Knowledge; Laboratories; Laboratory Research; Laboratory Study; Literature; Mentors; Mentorship; Methods; Modeling; National Institute on Alcohol Abuse and Alcoholism; Participant; Pathology; Pattern; Persons; Positioning Attribute; Process; Psychophysiology; Reporting; Research; Research Personnel; Research Training; Rewards; Sampling; Science; Secure; Sedation procedure; Social Facilitation; Statistical Models; Symptoms; System; Testing; Theoretical model; Time; Training; Youth; addiction; age group; alcohol craving; alcohol cue; alcohol effect; alcohol research; alcohol response; alcohol use disorder; allostasis; career; career development; craving; critical developmental period; critical period; design; drinking; early drinking; experience; improved; innovation; legal drinking age; negative affect; novel; novel strategies; patient oriented; pleasure; pressure; preventive intervention; programs; prospective test; public health relevance; response; secondary analysis; skills; social; statistics; theories; underage drinker; underage drinking

PROJECT SUMMARY/ABSTRACT Adolescents have higher rates of alcohol consumption than any other age group, and Alcohol Use Disorder (AUD) typically onsets during the adolescent years, prior to the legal drinking age. Accordingly, theoretical models of AUD suggest that early drinking experiences influence the progression of AUD symptoms. Further, repeated drinking is thought to alter the brain’s reward systems, leading to clinical manifestation of AUD over time. These theories are founded in direct research of alcohol’s effects with adolescent animals and laboratory or retrospective reports with human adults. However, concepts such as adolescents’ subjective alcohol responses and craving are difficult to model in animals and may not be accurately reflected in human adults with several years of drinking experience. Thus, innovative research that taps these constructs in human adolescents is essential to build theory and inform practice. This resubmission of K23 proposal AA024808-01, Novel Approaches to Understanding How Alcohol Pathology Develops in Adolescents, outlines a well-integrated research and training plan for mentored, patient-oriented career development. The proposed research seeks to understand how subjective responses to alcohol and craving change during the developmentally-critical period of adolescence through the application of longitudinal ecological momentary assessment (EMA) paired with psychophysiological assessment in a more controlled setting. Participants, ages 15 to 17 years, who report alcohol consumption but do not meet criteria for AUD, will complete three, 24-day EMA bursts and three laboratory sessions over one year. Laboratory psychophysiological assessments will include mean arterial pressure, heart rate, and startle eye blink electromyography. EMA will include randomly sampled and self- initiated reports of subjective states across drinking and non-drinking days. Hypotheses of within-person processes of change will be evaluated primarily with longitudinal latent variable methods. This research plan provides the necessary landscape for experiential learning and mentored training in applying developmentally informed models of AUD to theory and practice, bridging laboratory and real-world research findings, and testing dynamic theories of AUD development. An impressive mentorship team with complimentary expertise in EMA methods, adolescent development, psychophysiological research, longitudinal modeling, and clinical research applications will guide training in these areas. The proposed 5-year career development period will facilitate a successful transition to independence and aid in securing future research funding to apply novel methods and statistics within a developmental framework. The proposed research seeks to address major barriers to the advancement of leading AUD theories, with the ultimate goal of identifying more effective prevention and early intervention approaches. Thus, this proposal is well-aligned with NIAAA’s underage drinking research initiative that promotes research to understand factors compelling youth to progress from initial alcohol use to harmful use to AUD.

项目摘要/摘要 青少年的饮酒率高于任何其他年龄段，而酒精疾病障碍 （AUD）通常在青少年时期，在合法饮酒年龄之前就开始进行。根据理论 AUD模型表明，早期饮酒经验会影响AUD症状的进展。更远， 一再饮酒被认为会改变大脑的奖励系统，从而导致AUD的临床表现 时间。这些理论建立在对酒精对青少年动物和实验室的影响的直接研究中 或与人类成年人的回顾性报告。但是，诸如青少年主观酒精之类的概念 反应和渴望在动物中很难建模，并且在人类成年人中可能无法准确反映 几年的饮酒经验。那是在人类青少年中挖掘这些结构的创新研究 对于建立理论并为实践提供信息至关重要。 K23提案AA024808-01的重新提交，小说 理解酒精病理学如何在青少年发展的方法，概述了一个整合的 研究和培训计划针对受患者的职业发展。拟议的研究试图 了解在关键时期对酒精和渴望变化的主观反应 通过应用与纵向生态瞬时评估（EMA）的应用 心理生理评估在更受控的环境中。年龄15至17岁的参与者报告 酒精消耗但不符合AUD的标准，将完成三，24天EMA爆发和三个 实验室会议一年。实验室心理生理评估将包括平均动脉 压力，心率和惊吓眼闪烁肌电图。 EMA将包括随机采样和自我采样 在饮酒和不喝酒的日子中发起了主观状态的报告。人身内的假设 变化过程将主要使用纵向潜在可变方法评估。该研究计划 为经验丰富的学习提供必要的景观 明智的AUD符合理论和实践的模型，桥接实验室和现实世界研究结果以及测试 AUD开发的动态理论。一个令人印象深刻的心态团队，拥有EMA的免费专业知识 方法，青少年发展，心理生理研究，纵向建模和临床研究 申请将指导这些领域的培训。拟议的5年职业发展期将有助于 成功过渡到独立性，并有助于确保未来的研究资金应用新颖的方法和 发展框架内的统计数据。拟议的研究旨在解决针对的主要障碍 领先的唱机理论的进步，其最终目标是确定更有效的预防和早期 干预方法。这是与NIAAA的未成年饮酒研究计划完善的建议 促进研究以理解因素迫使青年从最初的酒精使用到有害的因素 用于aud。

项目成果

Comparing daily drivers of problem drinking among older and younger adults: An electronic daily diary study using smartphones.

• DOI: 10.1016/j.drugalcdep.2017.11.012
• 发表时间: 2018-02-01
• 期刊: Drug and alcohol dependence
• 影响因子: 4.2
• 作者: Kuerbis A;Treloar Padovano H;Shao S;Houser J;Muench FJ;Morgenstern J
• 通讯作者: Morgenstern J

A Secondary Analysis from a Randomized Trial on the Effect of Plasma Tetrahydrocannabinol Levels on Pain Reduction in Painful Diabetic Peripheral Neuropathy.

血浆四氢大麻酚水平对疼痛性糖尿病周围神经病变疼痛减轻影响的随机试验的二次分析。

• DOI: 10.1016/j.jpain.2020.03.003
• 发表时间: 2020
• 期刊: The journal of pain
• 作者: Wallace,MarkS;Marcotte,ThomasD;Atkinson,JH;Padovano,HayleyTreloar;Bonn-Miller,Marcel
• 通讯作者: Bonn-Miller,Marcel