Novel Approaches to Understanding How Alcohol Pathology Develops in Adolescents

了解青少年酒精病理学如何发展的新方法

• 批准号: 10092877
• 负责人: Hayley Treloar Padovano
• 金额: $ 19.45万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10092877
• 关键词: Active Learning; Address; Adolescence; Adolescent; Adolescent Development; Adult; Affect; Affective; Age; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcoholism; Alcohols; Animals; Area; Award; Blinking; Blood Pressure; Blood alcohol level measurement; Brain; Clinical; Clinical Research; Cognitive; Complex; Cross-Sectional Studies; Cues; Data; Data Set; Depressed mood; Desire for food; Development; Early Intervention; Ecological momentary assessment; Electromyography; Elements; Emotional; Emotions; Enrollment; Environment; Ethics; Etiology; Feeling; Foundations; Funding; Goals; Happiness; Heart Rate; Human; Impairment; Incentives; Knowledge; Laboratories; Laboratory Research; Laboratory Study; Literature; Mentors; Mentorship; Methods; Modeling; National Institute on Alcohol Abuse and Alcoholism; Participant; Pathology; Pattern; Persons; Positioning Attribute; Process; Psychophysiology; Reporting; Research; Research Personnel; Research Training; Rewards; Sampling; Science; Secure; Sedation procedure; Social Facilitation; Statistical Models; Symptoms; System; Testing; Theoretical model; Time; Training; Youth; addiction; age group; alcohol craving; alcohol cue; alcohol effect; alcohol research; alcohol response; alcohol use disorder; allostasis; career; career development; craving; critical developmental period; critical period; design; drinking; early drinking; experience; improved; innovation; legal drinking age; negative affect; novel; novel strategies; patient oriented; pleasure; pressure; preventive intervention; programs; prospective test; public health relevance; response; secondary analysis; skills; social; statistics; theories; underage drinker; underage drinking

PROJECT SUMMARY/ABSTRACT Adolescents have higher rates of alcohol consumption than any other age group, and Alcohol Use Disorder (AUD) typically onsets during the adolescent years, prior to the legal drinking age. Accordingly, theoretical models of AUD suggest that early drinking experiences influence the progression of AUD symptoms. Further, repeated drinking is thought to alter the brain’s reward systems, leading to clinical manifestation of AUD over time. These theories are founded in direct research of alcohol’s effects with adolescent animals and laboratory or retrospective reports with human adults. However, concepts such as adolescents’ subjective alcohol responses and craving are difficult to model in animals and may not be accurately reflected in human adults with several years of drinking experience. Thus, innovative research that taps these constructs in human adolescents is essential to build theory and inform practice. This resubmission of K23 proposal AA024808-01, Novel Approaches to Understanding How Alcohol Pathology Develops in Adolescents, outlines a well-integrated research and training plan for mentored, patient-oriented career development. The proposed research seeks to understand how subjective responses to alcohol and craving change during the developmentally-critical period of adolescence through the application of longitudinal ecological momentary assessment (EMA) paired with psychophysiological assessment in a more controlled setting. Participants, ages 15 to 17 years, who report alcohol consumption but do not meet criteria for AUD, will complete three, 24-day EMA bursts and three laboratory sessions over one year. Laboratory psychophysiological assessments will include mean arterial pressure, heart rate, and startle eye blink electromyography. EMA will include randomly sampled and self- initiated reports of subjective states across drinking and non-drinking days. Hypotheses of within-person processes of change will be evaluated primarily with longitudinal latent variable methods. This research plan provides the necessary landscape for experiential learning and mentored training in applying developmentally informed models of AUD to theory and practice, bridging laboratory and real-world research findings, and testing dynamic theories of AUD development. An impressive mentorship team with complimentary expertise in EMA methods, adolescent development, psychophysiological research, longitudinal modeling, and clinical research applications will guide training in these areas. The proposed 5-year career development period will facilitate a successful transition to independence and aid in securing future research funding to apply novel methods and statistics within a developmental framework. The proposed research seeks to address major barriers to the advancement of leading AUD theories, with the ultimate goal of identifying more effective prevention and early intervention approaches. Thus, this proposal is well-aligned with NIAAA’s underage drinking research initiative that promotes research to understand factors compelling youth to progress from initial alcohol use to harmful use to AUD.

项目总结/摘要 青少年的酒精消费率高于任何其他年龄组，酒精使用障碍 (AUD)通常在青少年时期，在法律的饮酒年龄之前发作。因此，理论上 AUD模型表明早期饮酒经历影响AUD症状的进展。此外，本发明还 反复饮酒被认为会改变大脑的奖励系统，导致AUD的临床表现。 时间这些理论是建立在酒精对青春期动物和实验室的影响的直接研究上的。 或成人的回顾性报告。然而，青少年主观饮酒等概念 反应和渴望很难在动物中建模，并且可能无法准确地反映在成年人中， 多年的饮酒经验。因此，在人类青少年中利用这些结构的创新研究 对建立理论和指导实践至关重要。K23提案AA 024808 -01（新型）的重新提交 了解酒精病理学如何在青少年中发展的方法，概述了一个完整的 研究和培训计划，指导，以病人为导向的职业发展。拟议的研究旨在 了解在发育关键期对酒精和渴望的主观反应如何变化 通过应用纵向生态瞬时评估（EMA）， 在一个更可控的环境中进行心理生理评估。参与者，年龄在15至17岁之间， 酒精消费，但不符合标准的澳元，将完成三个，24天EMA突破和三个 一年多的实验室。实验室心理生理学评估将包括平均动脉 血压心率和惊吓眨眼肌电图EMA将包括随机抽样和自我- 在饮酒和不饮酒的日子里开始报告主观状态。人内假设 变化过程将主要用纵向潜变量方法进行评估。这项研究计划 为体验式学习和指导式培训提供必要的环境， AUD的知情模型的理论和实践，连接实验室和现实世界的研究结果，并测试 AUD发展的动态理论。一个令人印象深刻的导师团队，拥有EMA方面的专业知识 方法、青少年发展、心理生理学研究、纵向建模和临床研究 应用程序将指导这些领域的培训。拟议的5年职业发展期将有助于 成功过渡到独立，并帮助确保未来的研究资金，以应用新的方法， 在发展框架内的统计。拟议的研究旨在解决主要障碍， 先进的AUD理论，最终目标是确定更有效的预防和早期治疗。 干预方法。因此，该提案与NIAAA的未成年人饮酒研究倡议保持一致 促进研究，以了解促使青年从最初使用酒精发展到有害酒精的因素。 使用AUD。

项目成果

Comparing daily drivers of problem drinking among older and younger adults: An electronic daily diary study using smartphones.

• DOI: 10.1016/j.drugalcdep.2017.11.012
• 发表时间: 2018-02-01
• 期刊: Drug and alcohol dependence
• 影响因子: 4.2
• 作者: Kuerbis A;Treloar Padovano H;Shao S;Houser J;Muench FJ;Morgenstern J
• 通讯作者: Morgenstern J

A Secondary Analysis from a Randomized Trial on the Effect of Plasma Tetrahydrocannabinol Levels on Pain Reduction in Painful Diabetic Peripheral Neuropathy.

血浆四氢大麻酚水平对疼痛性糖尿病周围神经病变疼痛减轻影响的随机试验的二次分析。

• DOI: 10.1016/j.jpain.2020.03.003
• 发表时间: 2020
• 期刊: The journal of pain
• 作者: Wallace,MarkS;Marcotte,ThomasD;Atkinson,JH;Padovano,HayleyTreloar;Bonn-Miller,Marcel
• 通讯作者: Bonn-Miller,Marcel