Evaluating the Association between Cardiometabolic Health Over the Lifespan and Vertebral Strength
评估终生心脏代谢健康与椎骨强度之间的关联
基本信息
- 批准号:10586010
- 负责人:
- 金额:$ 68.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-03-01 至 2028-02-28
- 项目状态:未结题
- 来源:
- 关键词:AdultAttenuatedBiologicalBiological MarkersBiomechanicsBlack raceBone DensityBone ResorptionCardiometabolic DiseaseCentral obesityClassificationClinicalClinical DataCoronary Artery Risk Development in Young Adults StudyDataDependenceDual-Energy X-Ray AbsorptiometryElderlyEligibility DeterminationEquationEvaluationFemaleFractureGoalsHealthHyperlipidemiaHypertensionImageIndividualInflammationInterventionInvestigationLife Cycle StagesLipidsLongevityMeasurementMeasuresMediatingMedicaidModelingMolecularNon-Insulin-Dependent Diabetes MellitusOsteoclastsOsteogenesisParticipantPatternPredictive FactorPublic HealthQuestionnairesRaceRenal functionResearch DesignResearch PersonnelRoleScanningSpinal FracturesTechnologyTimeUnited StatesVertebral BoneX-Ray Computed Tomographyabdominal CTagedbiomarker identificationblood glucose regulationbone healthbone massbone strengthburden of illnesscardiometabolismcardiovascular healthcohortepidemiology studyfracture riskfragility fractureglucose metabolismhealth assessmenthealth datahigh risk populationmalemenmortality risknovelnursing home length of staysexspine bone structurewomen of color
项目摘要
ABSTRACT
Fragility fractures are a substantial public health problem in older adults in the United States (US), with vertebral
fractures being the most prevalent fracture type. Cardiometabolic disorders (e.g., hypertension, type 2
diabetes mellitus, abdominal obesity, and hyperlipidemia) have been associated with lower bone strength, bone
mineral density (BMD), and higher fracture risk. Although several epidemiologic studies have evaluated the role
of cardiometabolic health on vertebral fractures, by not accounting for the clustering of cardiometabolic
conditions, many of the study findings are limited. Large studies with the ability to adjust for multiple
cardiometabolic conditions are needed to provide information on the full effect of cardiometabolic conditions on
vertebral health, including BMD and strength. Studies evaluating molecular mechanisms of cardiometabolic
conditions on vertebral health also have study design limitations, including the lack of adjustment for clustering
of other cardiometabolic conditions and/or biomarkers, and cross-sectional evaluations where either the
cardiometabolic exposures and/or bone health data are assessed at a single time point. The lack of longitudinal
data limits our ability to understand how cardiometabolic health is related to vertebral health. Lastly, advances
in computed tomography (CT) technology has allowed for bone mass and strength measurements.
Biomechanical CT (BCT) analysis has allowed researchers to obtain validated bone mass and strength on CT
images obtained for other clinical indications, opening the investigation of the role of cardiometabolic disorders
on vertebral health in individuals who do not routinely receive DXA imaging (i.e. women of color and men). The
Coronary Artery Risk Development in Young Adults (CARDIA) study has followed 5,115 Black and White male
and female adults aged 18-30 years at baseline for 35 years. The proposed study will build on CARDIA’s
previously collected cardiometabolic disease and biomarker data. It will also add vertebral strength data through
BCT analysis of Year 25 and 35 abdominal CT scans. Our aims are to: 1) Evaluate the association between
cardiometabolic disease patterns and vertebral health, 2) Determine the role of cardiometabolic
biomarkers on vertebral health, and 3) Identify cardiometabolic health factors that predict 10-year
changes in vertebral health. Our overall goal is to provide unbiased and longitudinal estimates of the
association between cardiometabolic health and vertebral health, and to explore the potential biologic
mechanisms of these associations. Determining how cardiometabolic disease patterns and biomarkers, at
clinical or subclinical levels, impact vertebral bone health is highly desirable and can lead to changes in fracture
screening protocols in this high risk population.
摘要
脆性骨折是美国(US)老年人的一个重大公共卫生问题,
骨折是最常见的骨折类型。心脏代谢疾病(例如,2型高血压
糖尿病、腹部肥胖和高脂血症)与骨强度、骨密度和骨密度降低有关。
矿物质密度(BMD),骨折风险更高。尽管一些流行病学研究已经评估了
心脏代谢健康对椎骨骨折的影响,
在这种情况下,许多研究结果是有限的。大型研究,能够调整多个
需要心脏代谢状况来提供关于心脏代谢状况对
脊椎健康,包括BMD和力量。评价心脏代谢的分子机制的研究
脊椎健康状况也有研究设计的局限性,包括缺乏对聚类的调整。
其他心脏代谢疾病和/或生物标志物,以及横断面评价,其中
在单个时间点评估心脏代谢暴露和/或骨骼健康数据。缺乏纵向
数据限制了我们理解心脏代谢健康如何与脊椎健康相关的能力。最后,进步
在计算机断层扫描(CT)技术中,允许进行骨质量和强度测量。
生物力学CT(BCT)分析使研究人员能够在CT上获得经验证的骨量和强度
为其他临床适应症获得的图像,开启了对心脏代谢疾病作用的研究
不定期接受DXA成像的个体(即有色人种女性和男性)的脊椎健康。的
年轻人冠状动脉风险发展(CARDIA)研究跟踪了5,115名黑人和白色男性
和基线时年龄为18-30岁的女性成年人,持续35年。拟议的研究将建立在CARDIA的
先前收集的心脏代谢疾病和生物标志物数据。它还将通过以下方式添加椎骨强度数据:
25岁和35岁腹部CT扫描的BCT分析。我们的目标是:1)评估之间的关联
心脏代谢疾病模式和脊椎健康,2)确定心脏代谢疾病的作用,
脊椎健康的生物标志物,和3)确定心脏代谢健康因素,预测10年
脊椎健康的变化。我们的总体目标是提供无偏的纵向估计,
心脏代谢健康和脊椎健康之间的联系,并探索潜在的生物学
这些协会的机制。确定心脏代谢疾病模式和生物标志物,
临床或亚临床水平,影响椎体骨健康是非常可取的,并可能导致骨折的变化
在这个高危人群中进行筛查。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Nicole C Wright其他文献
Nicole C Wright的其他文献
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{{ truncateString('Nicole C Wright', 18)}}的其他基金
Biology or Management: Understanding Racial Differences in Post Fracture Outcomes
生物学或管理学:了解骨折后结果的种族差异
- 批准号:
9769512 - 财政年份:2017
- 资助金额:
$ 68.01万 - 项目类别:
Biology or Management: Understanding Racial Differences in Post Fracture Outcomes
生物学或管理学:了解骨折后结果的种族差异
- 批准号:
9313990 - 财政年份:2017
- 资助金额:
$ 68.01万 - 项目类别:
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