Pilot and Exploratory Studies Core

摘要 试点和探索性研究核心（PESC）的目标是为将开发的研究提供支持。 并测试与中心总体主题高度相关的新研究思路：提高对如何 代谢因子和炎症与年龄相关疾病和合并症相互作用， 与流动性和功能状况有关的成果。因此，PESC将资助广泛的试点研究。 一系列学科，从基础，临床前，临床患者为导向的研究，通过行为和健康 服务研究。每个提交的建议将首先接受至少三个科学价值的评估， 外部评审员，然后由OAIC领导进一步评估与中心目标的相关性。的 PESC自1989年成立以来已提供了155笔试点赠款，其中大部分提供给初级教师，其中许多人现在已经 在老年医学和相关学科建立了自己的生产力独立研究人员。 2020-2021年（竞争续租第一年）已选出五个项目，包括：1）类型2 老年非裔美国男性的糖尿病自我管理：同伴领导者试点干预; 2）评估 生物bDMARD（生物疾病缓解抗风湿药物）在老年人中的增加 风湿性关节炎; 3）家庭送餐，以防止复发性肝性脑病： BRAINFOOD随机对照试验; 4）降级途径：描述抗生素处方 cascade级联for older老adults成年人. 5)蛋白质翻译动力学中的蛋白质翻译相关改变。PESC将是 导演：洛娜·莫迪和丹尼尔·戈德斯坦他们将与研究教育核心密切合作 (REC)和所有资源核心，以支持实施创新和有前途的项目 由年轻科学家提出，或更资深的研究人员新的老化研究，增加的可能性， 项目将导致外部支持的老龄化研究。

Abstract The goal of the Pilot and Exploratory Studies Core (PESC) is to provide support for studies that will develop and test new research ideas of high relevance to the Center’s overall theme: improve understanding of how metabolic factors and inflammation interact with age-related diseases and comorbidities to determine key health outcomes related to mobility and functional status. The PESC will thus fund pilot research studies over a wide range of disciplines, from basic, pre-clinical, clinical patient-oriented research through behavioral and health services research. Each submitted proposal will first receive an evaluation for scientific merit by at least three external reviewers and then be further evaluated by OAIC leaders for relevance to the Center objectives. The PESC has made 155 pilot grants since its inception in 1989, mostly to junior faculty, many of whom have now established themselves as productive independent researchers in geriatric medicine and cognate disciplines. Five projects have been selected for 2020-2021 (Year 1 of the competing renewal), including: 1) Type 2 Diabetes Self-Management in Older African American Men: A Peer Leader Pilot Intervention; 2) Evaluate de- escalation of biologic bDMARDs (biologic disease modifying anti-rheumatic drugs) among older adults with Rheumatoid Arthritis; 3) Home-delivered meals to prevent recurrent hepatic encephalopathy: The BRAINFOOD randomized controlled trial; 4) Pathway to De-escalation: Characterizing antibiotic prescribing cascade for older adults. 5) Age-associated alterations in protein translation dynamics. The PESC will be directed by Drs. Lona Mody and Daniel Goldstein. They will work closely with the Research Education Core (REC) and all the Resource Cores (RCs) to support implementation of innovative and promising projects proposed by junior scientists, or more senior investigators new to aging research, increasing the likelihood that projects will lead to externally supported research in aging.