Lateral Hypothalamic Circuits for Feeding and Reinforcement
用于喂养和强化的外侧下丘脑回路
基本信息
- 批准号:10588126
- 负责人:
- 金额:$ 45.81万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-05-01 至 2026-02-28
- 项目状态:未结题
- 来源:
- 关键词:AnatomyAnimal FeedAnimalsAppetitive BehaviorArchitectureAreaBehavioralBrainBrain regionCalciumCell physiologyCellsCodeCommunitiesConsummatory BehaviorConsumptionDataData SetDesire for foodDiseaseDynorphinsElectric StimulationElementsFastingFoodFoundationsFundingFutureGene ExpressionGene Expression ProfileGene Expression ProfilingGenesGeneticGenetic TranscriptionGlutamatesGoalsHabenulaHeadHourHypothalamic structureImageIndividualLateralLateral Hypothalamic AreaLinkMental disordersModificationMolecularMolecular ProfilingMonitorMotivationMusNeuroanatomyNeuronsNeuropeptidesNeurotensinOrganismOutputPathway interactionsPharmacology StudyPlayPopulationProcessPsychological reinforcementResearchResourcesResponse to stimulus physiologyRewardsRodentRoleSatiationSeminalShapesSignal TransductionSiteSomatostatinStimulusSucroseSupporting CellSurveysTestingThalamic structureTherapeutic InterventionVentral Tegmental AreaVentricularViralWorkaddictionbrain circuitrycell typedata resourcedifferential expressiondrug of abuseexperimental studyfeedinginsightinterdisciplinary approachmotivated behaviorneural circuitneuropsychiatric disordernoveloptogeneticsparabrachial nucleusreward processingsingle-cell RNA sequencingtemporal measurementtooltwo-photon
项目摘要
Abstract:
Motivated behaviors such as feeding and reward-seeking are critical for an organism's survival. These
processes require distributed neuronal networks and supporting cell types in multiple brain regions to be tightly
regulated and tuned in order to orchestrate behavioral output. The lateral hypothalamic area (LHA) has long
been identified as a critical neuroanatomical substrate for motivated behavior. Despite decades of research,
the molecular identity of defined LHA cell types remains poorly understood. Additionally, while LHA neurons
have been previously shown to encode appetitive and consummatory behaviors via distinct cellular ensembles,
it remains unknown how distinct LHA output neurons contribute to these processes. Here we propose to
continue to study the neural circuits of the LHA, and to identify how distinct cell types contribute to feeding and
reinforcement. Using an interdisciplinary approach to leverage cutting edge tools such as single cell
transcriptional profiling, two photon calcium imaging, and viral we aim to undercover key circuit elements, and
novel circuit specific gene expression patterns that can be leveraged for future therapeutic interventions for
addiction and other neuropsychiatric disorders.
摘要:
进食和寻求奖励等动机行为对生物体的生存至关重要。这些
这些过程需要分布在多个大脑区域的神经元网络和支持细胞类型紧密结合,
调节和调整以协调行为输出。下丘脑外侧区(LHA)具有长的
被认为是动机行为的关键神经解剖学基础。尽管经过几十年的研究,
确定的LHA细胞类型的分子特性仍然知之甚少。此外,虽然LHA神经元
先前已经显示出通过不同的细胞系综编码食欲和消费行为,
仍然不知道不同的LHA输出神经元如何对这些过程做出贡献。在此,我们建议
继续研究LHA的神经回路,并确定不同的细胞类型如何有助于进食,
加固.使用跨学科的方法来利用尖端工具,如单细胞
转录分析,双光子钙成像,和病毒,我们的目标是卧底关键电路元件,
新的电路特异性基因表达模式,可用于未来的治疗干预,
成瘾和其他神经精神障碍。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Garret D Stuber其他文献
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{{ truncateString('Garret D Stuber', 18)}}的其他基金
2023 Catecholamines Gordon Research Conference and Gordon Research Seminar
2023年儿茶酚胺戈登研究会议暨戈登研究研讨会
- 批准号:
10753909 - 财政年份:2023
- 资助金额:
$ 45.81万 - 项目类别:
Lateral Hypothalamic Circuits for Feeding and Reinforcement
用于喂养和强化的外侧下丘脑回路
- 批准号:
10396988 - 财政年份:2021
- 资助金额:
$ 45.81万 - 项目类别:
Neural circuit elements that orchestrate cue-reward associations
协调提示-奖励关联的神经回路元件
- 批准号:
9815755 - 财政年份:2019
- 资助金额:
$ 45.81万 - 项目类别:
Neural circuit elements that orchestrate cue-reward associations
协调提示-奖励关联的神经回路元件
- 批准号:
10116349 - 财政年份:2019
- 资助金额:
$ 45.81万 - 项目类别:
Neural circuit elements that orchestrate cue-reward associations
协调提示-奖励关联的神经回路元件
- 批准号:
10324792 - 财政年份:2019
- 资助金额:
$ 45.81万 - 项目类别:
Neural circuit elements that orchestrate cue-reward associations
协调提示-奖励关联的神经回路元件
- 批准号:
9912731 - 财政年份:2019
- 资助金额:
$ 45.81万 - 项目类别:
Midbrain Neural Circuit Elements That Underlie Cue-Reward Associations
提示奖励关联背后的中脑神经回路元件
- 批准号:
8803135 - 财政年份:2014
- 资助金额:
$ 45.81万 - 项目类别:
Lateral Hypothalamic Circuits for Feeding and Reinforcement
用于喂养和强化的外侧下丘脑回路
- 批准号:
9322610 - 财政年份:2014
- 资助金额:
$ 45.81万 - 项目类别:
Lateral Hypothalamic Circuits for Feeding and Reinforcement
用于喂养和强化的外侧下丘脑回路
- 批准号:
8867196 - 财政年份:2014
- 资助金额:
$ 45.81万 - 项目类别:
Lateral Hypothalamic Circuits for Feeding and Reinforcement
用于喂养和强化的外侧下丘脑回路
- 批准号:
9109111 - 财政年份:2014
- 资助金额:
$ 45.81万 - 项目类别:
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