Clinical Translation and Validation Core

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The goal of the Clinical Translation and Validation Core is to use the science and practice of geriatrics and gerontology to assess the feasibility and clinical utility of artificial intelligence (AI) methods for clinical decision support and of new technology for monitoring aging adults in their home. Recognizing that geriatric syndromes and functional and cognitive impairment are the most important predictors of health outcomes and quality of life in older adults, and that current clinical approaches to identifying and preventing these conditions are reactive, this core's efforts are rooted in the belief that AI and home monitoring hold tremendous promise for disrupting the clinical paradigm and revolutionizing the detection, monitoring, and care of older adults and those with AD/ADRD. The core leadership will use their collective expertise in AD/ADRD, geriatrics, gerontology, and AI to work closely with the other PennAITech Collaboratory Cores to support training, stakeholder engagement, and pilot projects that promote the feasibility and utility of AI methods for decision support and new technology in the home. Together, this team will accomplish the following aims: (1) establish an expert panel to assess the feasibility and clinical value of new artificial intelligence models for predictive analytics and clinical decision support and of new technologies designed to monitor aging adults and those with AD/ADRD; (2) collaborate with the Technology Identification and Training Core and the Networking and Mentoring Core to build and make available a searchable database of new artificial intelligence software and home monitoring technology for the purpose of making connections with those interested in collaborating, evaluating, or adopting such tools; (3) establish a national resource for the evaluation and deployment of artificial intelligence models for predictive analytics and clinical decision support; and (4) partner with the Stakeholder Engagement Core to establish a network of sites and settings which can serve as a testbed for new technologies designed to monitor aging adults and those with AD/ADRD with an emphasis on underserved and rural populations.