A streamlined, high-throughput platform for validation of cancer antigen presentation and isolation of cancer antigen reactive T cells

一个简化的高通量平台,用于验证癌症抗原呈递和分离癌症抗原反应性 T 细胞

基本信息

  • 批准号:
    10272349
  • 负责人:
  • 金额:
    $ 39.49万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-23 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

Abstract T cell receptor (TCR) based cancer immunotherapies, either infusing expanded patient autologous tumor- specific T cells or infusing cancer-specific TCR engineered autologous T cells, have shown great clinical benefit in several types of cancer. However, two challenges have prevented the broad application of these therapies to many types of cancer. First, there lacks a quick and sensitive method to detect patient-specific presentation of cancer antigen peptides on the surface of tumor cells. Second, there lacks a rapid method for the isolation of antigen-specific T cells that can be propagated quickly in vitro to meet the real-time needs of adoptive cell transfer therapy. These challenges have become road blocks for the application of TCR based cancer immunotherapy to many types of cancer and have prevented the exploration of other classes of cancer-antigens in addition to neo-antigens (NeoAs) that also have therapeutic potential, such as cancer germline antigens (CGA). In this study, we propose the development of AbTR (Antigen sensing-based T cell Recall) technology to address these two critical challenges in large scale. The AbTR technology will provide a quick and streamlined path to identify cancer antigens presented on tumor cell from hundreds of possible targets and isolate many antigen- specific T cell clones that are functionally capable of killing tumor cells and are ready to be used in adoptive cell transfer therapy. The success of the project address two urgent needs in cancer immunotherapy. This technology not only can be applied to all types of cancer but may also be relevant for the study of other immunological diseases, such as infection and autoimmune diseases.
摘要

项目成果

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Amy Brock其他文献

Amy Brock的其他文献

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{{ truncateString('Amy Brock', 18)}}的其他基金

Instability of Cancer Cell States in Tumor progression (ICCS)
肿瘤进展过程中癌细胞状态的不稳定性 (ICCS)
  • 批准号:
    10491691
  • 财政年份:
    2021
  • 资助金额:
    $ 39.49万
  • 项目类别:
A streamlined, high-throughput platform for validation of cancer antigen presentation and isolation of cancer antigen reactive T cells
一个简化的高通量平台,用于验证癌症抗原呈递和分离癌症抗原反应性 T 细胞
  • 批准号:
    10493222
  • 财政年份:
    2021
  • 资助金额:
    $ 39.49万
  • 项目类别:
Instability of Cancer Cell States in Tumor progression (ICCS)
肿瘤进展过程中癌细胞状态的不稳定性 (ICCS)
  • 批准号:
    10212099
  • 财政年份:
    2021
  • 资助金额:
    $ 39.49万
  • 项目类别:
Systems Approaches to Understanding Subpopulation Heterogeneity in Therapeutic Resistance
理解治疗耐药性亚群异质性的系统方法
  • 批准号:
    10057183
  • 财政年份:
    2020
  • 资助金额:
    $ 39.49万
  • 项目类别:
Systems Approaches to Understanding Subpopulation Heterogeneity in Therapeutic Resistance
理解治疗耐药性亚群异质性的系统方法
  • 批准号:
    10256717
  • 财政年份:
    2020
  • 资助金额:
    $ 39.49万
  • 项目类别:
Systems Approaches to Understanding Subpopulation Heterogeneity in Therapeutic Resistance
理解治疗耐药性亚群异质性的系统方法
  • 批准号:
    10468211
  • 财政年份:
    2020
  • 资助金额:
    $ 39.49万
  • 项目类别:
Systems Approaches to Understanding Subpopulation Heterogeneity in Therapeutic Resistance
理解治疗耐药性亚群异质性的系统方法
  • 批准号:
    10524210
  • 财政年份:
    2020
  • 资助金额:
    $ 39.49万
  • 项目类别:
Systems Approaches to Understanding Subpopulation Heterogeneity in Therapeutic Resistance
理解治疗耐药性亚群异质性的系统方法
  • 批准号:
    10307901
  • 财政年份:
    2020
  • 资助金额:
    $ 39.49万
  • 项目类别:
Systems Approaches to Understanding Subpopulation Heterogeneity in Therapeutic Resistance
理解治疗耐药性亚群异质性的系统方法
  • 批准号:
    10388446
  • 财政年份:
    2020
  • 资助金额:
    $ 39.49万
  • 项目类别:
Systems Approaches to Understanding Subpopulation Heterogeneity in Therapeutic Resistance
理解治疗耐药性亚群异质性的系统方法
  • 批准号:
    10759093
  • 财政年份:
    2020
  • 资助金额:
    $ 39.49万
  • 项目类别:

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