Image-Guided Focused Ultrasound Treatment of Abscesses

图像引导聚焦超声治疗脓肿

• 批准号: 10274231
• 负责人: Thomas Matula
• 金额: $ 67.55万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10274231
• 关键词: Abscess; Acoustics; Acute; Acute-Phase Proteins; Affect; Aftercare; Animals; Antibiotic Resistance; Antibiotics; Bacteria; Blood; Blood Circulation; Body part; Caring; Catheter Management; Catheters; Chronic; Clinical Data; Clinical Trials; Connective Tissue; Data; Development; Devices; Disease; Dose; Drainage procedure; Drug resistance; Evaluation; Extravasation; Family suidae; Fine needle aspiration biopsy; Focused Ultrasound; Focused Ultrasound Therapy; Gaussian model; Goals; Healthcare; Hematoma; Histologic; Hospital Charges; Hospitalization; Human; Image; In Vitro; Infection; Injury; Length of Stay; Life; Lipopolysaccharides; Liquid substance; Measures; Mechanics; Methods; Microbe; Modality; Modeling; Monitor; Morbidity - disease rate; Needles; Operative Surgical Procedures; Oryctolagus cuniculus; Outcome; Outpatients; Patients; Pattern; Physicians; Physiologic pulse; Positioning Attribute; Protocols documentation; Public Health; Pus; Radiation; Rattus; Safety; Specific qualifier value; Stream; Structure; Surgical complication; Time; Training; Trauma; Treatment Efficacy; Treatment Protocols; Ultrasonic Therapy; Ultrasonography; Viscosity; arm; base; capsule; clinically relevant; contrast enhanced; first-in-human; healing; hospital readmission; image guided; improved; in vivo; innovation; pre-clinical; procedural pain; pus collection; response; risk minimization; standard of care; success

Abscesses are infected walled-off fluid collections of pus and bacteria and represent a ubiquitous global healthcare problem. They are common sequelae of surgery, infections, or disease, and can affect any part of the body. Current standard of care includes hospitalization, antibiotics, and drainage of the abscess with a catheter. The bacteria in pus are susceptible mechanical damage with High Intensity Focused Ultrasound (HIFU), which generates localized cavitation and is a potential noninvasive means to treat abscesses. The significance of this proposal is that treatment of abscesses using ultrasound therapy under ultrasound guidance is better for the patient because it is minimally- or non-invasive, has less procedural pain, doesn’t require that the patient live for up to several weeks with a drain inserted, requires no catheter management, there is no potential tract for new infections, and no need for CT/fluoro imaging radiation. Furthermore, ultrasound treatment will reduce the need for antibiotics, and thus reduce the potential for drug resistant, life-threatening microbes.

脓肿是感染的脓液和细菌的封闭液体集合，代表了 普遍存在的全球医疗保健问题。它们是手术、感染、 或疾病，并且可以影响身体的任何部位。目前的护理标准包括 住院治疗、抗生素和导管引流脓肿。细菌在 脓液很容易受到高强度聚焦超声 (HIFU) 的机械损伤， 它会产生局部空化，是一种潜在的非侵入性治疗手段 脓肿。该提案的意义在于，使用脓肿治疗 超声引导下的超声治疗对患者来说更好，因为它 微创或无创，手术疼痛较少，不需要患者存活 插入引流管可维持长达数周，无需导管管理， 没有潜在的新感染途径，也不需要 CT/荧光成像辐射。 此外，超声治疗将减少对抗生素的需求，从而减少 潜在的耐药性、危及生命的微生物。