Image-Guided Focused Ultrasound Treatment of Abscesses

图像引导聚焦超声治疗脓肿

• 批准号: 10274231
• 负责人: Thomas Matula
• 金额: $ 67.55万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10274231
• 关键词: Abscess; Acoustics; Acute; Acute-Phase Proteins; Affect; Aftercare; Animals; Antibiotic Resistance; Antibiotics; Bacteria; Blood; Blood Circulation; Body part; Caring; Catheter Management; Catheters; Chronic; Clinical Data; Clinical Trials; Connective Tissue; Data; Development; Devices; Disease; Dose; Drainage procedure; Drug resistance; Evaluation; Extravasation; Family suidae; Fine needle aspiration biopsy; Focused Ultrasound; Focused Ultrasound Therapy; Gaussian model; Goals; Healthcare; Hematoma; Histologic; Hospital Charges; Hospitalization; Human; Image; In Vitro; Infection; Injury; Length of Stay; Life; Lipopolysaccharides; Liquid substance; Measures; Mechanics; Methods; Microbe; Modality; Modeling; Monitor; Morbidity - disease rate; Needles; Operative Surgical Procedures; Oryctolagus cuniculus; Outcome; Outpatients; Patients; Pattern; Physicians; Physiologic pulse; Positioning Attribute; Protocols documentation; Public Health; Pus; Radiation; Rattus; Safety; Specific qualifier value; Stream; Structure; Surgical complication; Time; Training; Trauma; Treatment Efficacy; Treatment Protocols; Ultrasonic Therapy; Ultrasonography; Viscosity; arm; base; capsule; clinically relevant; contrast enhanced; first-in-human; healing; hospital readmission; image guided; improved; in vivo; innovation; pre-clinical; procedural pain; pus collection; response; risk minimization; standard of care; success

Abscesses are infected walled-off fluid collections of pus and bacteria and represent a ubiquitous global healthcare problem. They are common sequelae of surgery, infections, or disease, and can affect any part of the body. Current standard of care includes hospitalization, antibiotics, and drainage of the abscess with a catheter. The bacteria in pus are susceptible mechanical damage with High Intensity Focused Ultrasound (HIFU), which generates localized cavitation and is a potential noninvasive means to treat abscesses. The significance of this proposal is that treatment of abscesses using ultrasound therapy under ultrasound guidance is better for the patient because it is minimally- or non-invasive, has less procedural pain, doesn’t require that the patient live for up to several weeks with a drain inserted, requires no catheter management, there is no potential tract for new infections, and no need for CT/fluoro imaging radiation. Furthermore, ultrasound treatment will reduce the need for antibiotics, and thus reduce the potential for drug resistant, life-threatening microbes.

脓肿是被感染的、被隔离的脓液和细菌的液体集合，代表脓肿