Image-Guided Focused Ultrasound Treatment of Abscesses

图像引导聚焦超声治疗脓肿

• 批准号: 10274231
• 负责人: Thomas Matula
• 金额: $ 67.55万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10274231
• 关键词: Abscess; Acoustics; Acute; Acute-Phase Proteins; Affect; Aftercare; Animals; Antibiotic Resistance; Antibiotics; Bacteria; Blood; Blood Circulation; Body part; Caring; Catheter Management; Catheters; Chronic; Clinical Data; Clinical Trials; Connective Tissue; Data; Development; Devices; Disease; Dose; Drainage procedure; Drug resistance; Evaluation; Extravasation; Family suidae; Fine needle aspiration biopsy; Focused Ultrasound; Focused Ultrasound Therapy; Gaussian model; Goals; Healthcare; Hematoma; Histologic; Hospital Charges; Hospitalization; Human; Image; In Vitro; Infection; Injury; Length of Stay; Life; Lipopolysaccharides; Liquid substance; Measures; Mechanics; Methods; Microbe; Modality; Modeling; Monitor; Morbidity - disease rate; Needles; Operative Surgical Procedures; Oryctolagus cuniculus; Outcome; Outpatients; Patients; Pattern; Physicians; Physiologic pulse; Positioning Attribute; Protocols documentation; Public Health; Pus; Radiation; Rattus; Safety; Specific qualifier value; Stream; Structure; Surgical complication; Time; Training; Trauma; Treatment Efficacy; Treatment Protocols; Ultrasonic Therapy; Ultrasonography; Viscosity; arm; base; capsule; clinically relevant; contrast enhanced; first-in-human; healing; hospital readmission; image guided; improved; in vivo; innovation; pre-clinical; procedural pain; pus collection; response; risk minimization; standard of care; success

Abscesses are infected walled-off fluid collections of pus and bacteria and represent a ubiquitous global healthcare problem. They are common sequelae of surgery, infections, or disease, and can affect any part of the body. Current standard of care includes hospitalization, antibiotics, and drainage of the abscess with a catheter. The bacteria in pus are susceptible mechanical damage with High Intensity Focused Ultrasound (HIFU), which generates localized cavitation and is a potential noninvasive means to treat abscesses. The significance of this proposal is that treatment of abscesses using ultrasound therapy under ultrasound guidance is better for the patient because it is minimally- or non-invasive, has less procedural pain, doesn’t require that the patient live for up to several weeks with a drain inserted, requires no catheter management, there is no potential tract for new infections, and no need for CT/fluoro imaging radiation. Furthermore, ultrasound treatment will reduce the need for antibiotics, and thus reduce the potential for drug resistant, life-threatening microbes.

脓肿是感染的脓和细菌的封闭液体集合， 普遍存在的全球医疗保健问题。它们是手术、感染、 或疾病，可以影响身体的任何部位。目前的护理标准包括 住院、抗生素和用导管引流脓肿。中的细菌 脓液易受高强度聚焦超声（HIFU）的机械损伤， 其产生局部空化并且是潜在的非侵入性治疗手段 公主。这项建议的意义在于， 在超声引导下的超声治疗对患者更好， 微创或非侵入性，手术疼痛更少，不需要患者存活 长达数周，插入引流管，不需要导管管理， 没有新感染的潜在管道，并且不需要CT/荧光成像辐射。 此外，超声波治疗将减少对抗生素的需求，从而减少 潜在的抗药性威胁生命的微生物。