Image-Guided Focused Ultrasound Treatment of Abscesses

图像引导聚焦超声治疗脓肿

• 批准号: 10274231
• 负责人: Thomas Matula
• 金额: $ 67.55万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10274231
• 关键词: Abscess; Acoustics; Acute; Acute-Phase Proteins; Affect; Aftercare; Animals; Antibiotic Resistance; Antibiotics; Bacteria; Blood; Blood Circulation; Body part; Caring; Catheter Management; Catheters; Chronic; Clinical Data; Clinical Trials; Connective Tissue; Data; Development; Devices; Disease; Dose; Drainage procedure; Drug resistance; Evaluation; Extravasation; Family suidae; Fine needle aspiration biopsy; Focused Ultrasound; Focused Ultrasound Therapy; Gaussian model; Goals; Healthcare; Hematoma; Histologic; Hospital Charges; Hospitalization; Human; Image; In Vitro; Infection; Injury; Length of Stay; Life; Lipopolysaccharides; Liquid substance; Measures; Mechanics; Methods; Microbe; Modality; Modeling; Monitor; Morbidity - disease rate; Needles; Operative Surgical Procedures; Oryctolagus cuniculus; Outcome; Outpatients; Patients; Pattern; Physicians; Physiologic pulse; Positioning Attribute; Protocols documentation; Public Health; Pus; Radiation; Rattus; Safety; Specific qualifier value; Stream; Structure; Surgical complication; Time; Training; Trauma; Treatment Efficacy; Treatment Protocols; Ultrasonic Therapy; Ultrasonography; Viscosity; arm; base; capsule; clinically relevant; contrast enhanced; first-in-human; healing; hospital readmission; image guided; improved; in vivo; innovation; pre-clinical; procedural pain; pus collection; response; risk minimization; standard of care; success

Abscesses are infected walled-off fluid collections of pus and bacteria and represent a ubiquitous global healthcare problem. They are common sequelae of surgery, infections, or disease, and can affect any part of the body. Current standard of care includes hospitalization, antibiotics, and drainage of the abscess with a catheter. The bacteria in pus are susceptible mechanical damage with High Intensity Focused Ultrasound (HIFU), which generates localized cavitation and is a potential noninvasive means to treat abscesses. The significance of this proposal is that treatment of abscesses using ultrasound therapy under ultrasound guidance is better for the patient because it is minimally- or non-invasive, has less procedural pain, doesn’t require that the patient live for up to several weeks with a drain inserted, requires no catheter management, there is no potential tract for new infections, and no need for CT/fluoro imaging radiation. Furthermore, ultrasound treatment will reduce the need for antibiotics, and thus reduce the potential for drug resistant, life-threatening microbes.

脓肿是感染的脓液和细菌的围围液，代表A 无处不在的全球医疗保健问题。它们是手术，感染的常见后遗症， 或疾病，可能会影响身体的任何部位。当前的护理标准包括 带导管的住院，抗生素和脓肿的排水。细菌中 脓液是易感的机械损伤，高强度聚焦超声（HIFU）， 它产生局部气态，是一种潜在的无创手段 脓肿。该提议的意义是使用 超声指导下的超声疗法对患者更好，因为它是 微小或非侵入性，程序性疼痛较少，不需要患者活着 在插入排水管的最多几周内，不需要导管管理， 没有潜在的新感染，也不需要CT/Fluoro成像辐射。 此外，超声处理将减少对抗生素的需求，从而减少 耐药，威胁生命的微生物的潜力。