HIFU for Noninvasive Abscess Treatment

 描述（由申请人提供）：脓肿是脓和细菌的感染性隔离液体集合，代表了普遍存在的全球医疗保健问题。它们是手术、感染或疾病的常见后遗症，可以影响身体的任何部位。目前的护理标准包括住院治疗、抗生素和用导管引流脓肿。细菌对热损伤和机械损伤都很敏感。高强度聚焦超声（HIFU）可以产生局部加热和空化，是一种潜在的无创治疗手段，通过利用一个或两个机制。该建议的意义在于，在超声引导下使用超声治疗对可触及的脓肿进行无创治疗对患者更好，因为它是无创的，允许治疗小脓肿，手术疼痛更少，不需要导管管理，没有新感染的潜在途径，并且不需要CT/荧光成像辐射。

 DESCRIPTION (provided by applicant): Abscesses are infected walled-off fluid collections of pus and bacteria, and represent a ubiquitous global healthcare problem. They are common sequelae of surgery, infections or disease, and can affect any part of the body. Current standard of care includes hospitalization, antibiotics and drainage of the abscess with a catheter. The bacteria in puss are susceptible to both thermal and mechanical damage. High Intensity Focused Ultrasound (HIFU) can generate localized heating and cavitation, and is a potential noninvasive means to treat abscesses by exploiting one or both mechanisms. The significance of this proposal is that noninvasive treatment of reachable abscesses using ultrasound therapy under ultrasound guidance is better for the patient because it is noninvasive, allows treatment of small abscesses, has less procedural pain, requires no catheter management, there is no potential tract for new infections, and no need for CT/fluoro imaging radiation.