HIFU for Noninvasive Abscess Treatment

HIFU 无创脓肿治疗

• 批准号: 9120875
• 负责人: Thomas Matula
• 金额: $ 58.43万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-05 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9120875
• 关键词: Abscess; Acoustics; Acute; Aerobic Bacteria; Affect; AlamarBlue; Anaerobic Bacteria; Animal Model; Antibiotic Therapy; Antibiotics; Autopsy; Bacteria; Biological Assay; Body part; Caring; Catheter Management; Catheters; Characteristics; Clinical; Coagulative necrosis; Control Groups; Data; Development; Devices; Disease; Drainage procedure; Drug resistance; Escherichia coli; Evolution; Exposure to; Focused Ultrasound Therapy; Growth; Health; Health Care Costs; Healthcare; Heating; Hospital Charges; Hospitalization; Human; Image; In Situ; In Vitro; Infection; Injury; Lead; Length of Stay; Liquid substance; Location; Measures; Mechanics; Modeling; Monitor; Morbidity - disease rate; Muscle; Operative Surgical Procedures; Oryctolagus cuniculus; Outpatients; Pain; Patients; Physicians; Pilot Projects; Pus; Radiation; Resolution; Risk; Sampling; Suspension substance; Suspensions; System; Systemic infection; Temperature; Testing; Therapeutic; Thigh structure; Time; Tissues; Training; Trauma; Treatment Efficacy; Ultrasonic Therapy; Ultrasonography; Viscosity; White Blood Cell Count procedure; bactericide; capsule; compare effectiveness; cost; effective therapy; image guided; improved; in vivo; killings; programs; pus collection; rectal; research study; screening; standard of care; treatment effect

 DESCRIPTION (provided by applicant): Abscesses are infected walled-off fluid collections of pus and bacteria, and represent a ubiquitous global healthcare problem. They are common sequelae of surgery, infections or disease, and can affect any part of the body. Current standard of care includes hospitalization, antibiotics and drainage of the abscess with a catheter. The bacteria in puss are susceptible to both thermal and mechanical damage. High Intensity Focused Ultrasound (HIFU) can generate localized heating and cavitation, and is a potential noninvasive means to treat abscesses by exploiting one or both mechanisms. The significance of this proposal is that noninvasive treatment of reachable abscesses using ultrasound therapy under ultrasound guidance is better for the patient because it is noninvasive, allows treatment of small abscesses, has less procedural pain, requires no catheter management, there is no potential tract for new infections, and no need for CT/fluoro imaging radiation.

 描述（由申请人提供）：脓肿是感染的脓液和细菌的封闭液体集合，代表了普遍存在的全球医疗保健问题。它们是手术、感染或疾病的常见后遗症，可以影响身体的任何部位。目前的护理标准包括住院治疗、抗生素和用导管引流脓肿。脓液中的细菌容易受到热损伤和机械损伤。高强度聚焦超声（HIFU）可以产生局部加热和空化，是一种利用一种或两种机制治疗脓肿的潜在非侵入性手段。该提案的意义在于，在超声引导下使用超声治疗对可触及脓肿进行无创治疗对患者来说更好，因为它是无创的，可以治疗小脓肿，手术疼痛较少，不需要导管管理，没有潜在的新感染途径，也不需要CT/荧光成像辐射。