Focused Ultrasound Treatment of Skin and Soft Tissue Abscesses

皮肤和软组织脓肿的聚焦超声治疗

• 批准号: 10339133
• 负责人: Thomas Matula
• 金额: $ 69.9万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-15 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10339133
• 关键词: Abscess; Accident and Emergency department; Aftercare; Animal Model; Animals; Antibiotic Therapy; Antibiotics; Antimicrobial Resistance; Area; Bacteria; Bacteroides fragilis; Biological Markers; Blood; Breast; C-reactive protein; Cellulitis; Chronic; Cicatrix; Communities; Complete Blood Count; Complex; Data; Development; Devices; Drainage procedure; Drug resistance; Drug usage; Economic Burden; Effectiveness; Emergency department visit; Escherichia coli; Etiology; Evolution; Expenditure; Family suidae; Fine needle aspiration biopsy; Focused Ultrasound; Focused Ultrasound Therapy; Gram-Negative Bacteria; Gram-Positive Bacteria; Health Care Costs; Healthcare; Histology; Homelessness; Hospitalization; Human; In Vitro; Incision and drainage; Infection; Injections; Injury; Inpatients; Intramuscular; Length of Stay; Maintenance; Measures; Mechanics; Methods; Modeling; Monitor; Morbidity - disease rate; Neck; Needles; Outpatients; Pain; Patients; Persons; Physicians; Physiologic pulse; Population; Procedures; Public Health; Pus; Radiation exposure; Reporting; Resistance; Resolution; Risk; Risk Factors; Secondary to; Site; Skin Tissue; Soft Tissue Infections; Staphylococcus aureus; Streptococcus; Structure; Technology; Time; Tissues; Training; Treatment Failure; Treatment Protocols; Ultrasonography; clinically relevant; cost; effective therapy; effectiveness evaluation; first-in-human; hospital readmission; image guided; imaging biomarker; improved; intraperitoneal; methicillin resistant Staphylococcus aureus; pathogen; patient population; porcine model; procedural pain; programs; psychosocial; secondary infection; soft tissue; standard of care; subcutaneous; success; treatment effect; ultrasound; wound care; wound healing; wound treatment

Skin and soft tissue infections (SSTIs) are among the most common infections encountered in ambulatory and inpatient settings with cellulitis and abscess being most common. Effective treatments are needed as SSTIs are a high-volume condition, and the overall healthcare burden remains high. SSTIs are one of the top causes for hospital readmissions. Furthermore, the standard of care, incision and drainage (I&D), is one of the most painful procedures in the emergency department. In addition to pain and the potential for unsightly scarring, other complications from I&D include damage to surrounding structures, an extension of the infection into adjacent tissues, bacteremic complications and reoccurrence. Furthermore, patient populations with psychosocial risk factors (e.g., homelessness, IV drug use) are prone to secondary infections and wound care remains problematic in these populations. Although bacteria can develop drug resistance, they remain susceptible to mechanical damage. In particular, short intense pulses of Focused Ultrasound (FUS), histotripsy, non-invasively generates localized cavitation that mechanically disrupts the bacteria and represents a new paradigm for non- invasive abscess treatment. We propose that histotripsy can non-invasively disinfect and liquefy many superficial and intramuscular abscesses allowing for complete fine needle aspiration. Our Aims are to expand our animal model to include MRSA pathogens and perform animal studies to advance this technology toward first in human studies. If successful, this approach could decrease patient morbidity, eliminate hospital stays, and lower healthcare costs.

皮肤和软组织感染(SSTI)是最常见的感染 在门诊和住院环境中遇到，最常见的是蜂窝织炎和脓肿 很普通。需要有效的治疗，因为SSTI是一种大容量的情况，并且 总体医疗负担仍然很高。性传播感染是医院的首要原因之一。 重新入院。此外，护理、切割和引流(I&D)的标准是 急诊科最痛苦的手术。除了痛苦和 可能会留下难看的疤痕，I&D的其他并发症包括 周围结构，感染延伸至邻近组织，菌血症 并发症和复发。此外，有心理社会风险的患者群体 因素(例如，无家可归、静脉注射药物使用)容易继发感染和伤口 在这些人群中，护理仍然是个问题。尽管细菌可以开发出药物 尽管存在阻力，但它们仍然容易受到机械损伤。特别是，空头紧张 聚焦超声(FUS)脉冲，组织学，非侵入性产生局部性 机械地破坏细菌的空化作用，代表了一种新的非 侵入性脓肿治疗。我们认为组织摩擦可以非侵入性地消毒和 液化许多浅表和肌肉内脓肿，允许完整的细针 渴望。我们的目标是扩大我们的动物模型，以包括MRSA病原体和 进行动物实验，将这项技术推向人类研究的第一。如果 如果成功，这种方法可以降低患者的发病率，减少住院时间，并 更低的医疗成本。