Focused Ultrasound Treatment of Skin and Soft Tissue Abscesses

皮肤和软组织脓肿的聚焦超声治疗

• 批准号: 10339133
• 负责人: Thomas Matula
• 金额: $ 69.9万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-15 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10339133
• 关键词: Abscess; Accident and Emergency department; Aftercare; Animal Model; Animals; Antibiotic Therapy; Antibiotics; Antimicrobial Resistance; Area; Bacteria; Bacteroides fragilis; Biological Markers; Blood; Breast; C-reactive protein; Cellulitis; Chronic; Cicatrix; Communities; Complete Blood Count; Complex; Data; Development; Devices; Drainage procedure; Drug resistance; Drug usage; Economic Burden; Effectiveness; Emergency department visit; Escherichia coli; Etiology; Evolution; Expenditure; Family suidae; Fine needle aspiration biopsy; Focused Ultrasound; Focused Ultrasound Therapy; Gram-Negative Bacteria; Gram-Positive Bacteria; Health Care Costs; Healthcare; Histology; Homelessness; Hospitalization; Human; In Vitro; Incision and drainage; Infection; Injections; Injury; Inpatients; Intramuscular; Length of Stay; Maintenance; Measures; Mechanics; Methods; Modeling; Monitor; Morbidity - disease rate; Neck; Needles; Outpatients; Pain; Patients; Persons; Physicians; Physiologic pulse; Population; Procedures; Public Health; Pus; Radiation exposure; Reporting; Resistance; Resolution; Risk; Risk Factors; Secondary to; Site; Skin Tissue; Soft Tissue Infections; Staphylococcus aureus; Streptococcus; Structure; Technology; Time; Tissues; Training; Treatment Failure; Treatment Protocols; Ultrasonography; clinically relevant; cost; effective therapy; effectiveness evaluation; first-in-human; hospital readmission; image guided; imaging biomarker; improved; intraperitoneal; methicillin resistant Staphylococcus aureus; pathogen; patient population; porcine model; procedural pain; programs; psychosocial; secondary infection; soft tissue; standard of care; subcutaneous; success; treatment effect; ultrasound; wound care; wound healing; wound treatment

Skin and soft tissue infections (SSTIs) are among the most common infections encountered in ambulatory and inpatient settings with cellulitis and abscess being most common. Effective treatments are needed as SSTIs are a high-volume condition, and the overall healthcare burden remains high. SSTIs are one of the top causes for hospital readmissions. Furthermore, the standard of care, incision and drainage (I&D), is one of the most painful procedures in the emergency department. In addition to pain and the potential for unsightly scarring, other complications from I&D include damage to surrounding structures, an extension of the infection into adjacent tissues, bacteremic complications and reoccurrence. Furthermore, patient populations with psychosocial risk factors (e.g., homelessness, IV drug use) are prone to secondary infections and wound care remains problematic in these populations. Although bacteria can develop drug resistance, they remain susceptible to mechanical damage. In particular, short intense pulses of Focused Ultrasound (FUS), histotripsy, non-invasively generates localized cavitation that mechanically disrupts the bacteria and represents a new paradigm for non- invasive abscess treatment. We propose that histotripsy can non-invasively disinfect and liquefy many superficial and intramuscular abscesses allowing for complete fine needle aspiration. Our Aims are to expand our animal model to include MRSA pathogens and perform animal studies to advance this technology toward first in human studies. If successful, this approach could decrease patient morbidity, eliminate hospital stays, and lower healthcare costs.

皮肤和软组织感染（SSTIs）是最常见的感染