CORE C: DMSC Core

核心 C：DMSC 核心

• 批准号: 10271795
• 负责人: Justin Benjamin Miller
• 金额: $ 34.15万
• 依托单位: CLEVELAND CLINIC FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10271795
• 关键词: Adopted; Alzheimer' s Disease; Alzheimer' s disease therapeutic; Animal Model; Architecture; Archives; Award; Biological Markers; Biometry; Brain; Brain imaging; California; Centers of Research Excellence; Characteristics; Clinic; Clinical Research; Cognitive; Collaborations; Communities; Complex; Computer software; Consultations; Data; Data Analyses; Data Element; Data Science; Data Set; Databases; Derivation procedure; Development; Disease; Doctor of Philosophy; Elderly; Ensure; Faculty; Formulation; Fostering; Foundations; Friction; Funding; Future; Genetic; Goals; Growth; Human; Image; Individual; Inflammation; Informatics; Information Technology; Infrastructure; Investments; Knowledge; Lead; Leadership; Liquid substance; Mentorship; Modernization; Nerve Degeneration; Neurodegenerative Disorders; Neurology; Neuropsychology; Neurosciences; Neurosciences Research; Nevada; Parkinson Disease; Participant; Patients; Phase; Positioning Attribute; Practice Management; Process; Publications; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Sample Size; Scientific Advances and Accomplishments; Secure; Security; Services; Source; Structure; System; Technology; Testing; Training; Translating; Translational Research; Universities; Validation; Work; Writing; advanced analytics; base; biomedical informatics; brain health; career; cloud based; cohesion; cohort; data framework; data infrastructure; data management; data streams; digital; electronic data; flexibility; high standard; industry partner; informatics infrastructure; innovation; insight; interest; member; multidisciplinary; neuroimaging; novel; novel strategies; open source; protocol development; quantitative imaging; research and development; sound; statistics; tool; translational neuroscience

SUMMARY/ABSTRACT Data Management and Statistics Core (DMSC) The Data Management and Statistics Core (DMSC) is an integral component of the Center for Neurodegeneration and Translational Neuroscience (CNTN), providing each project and core with the digital infrastructure for accurate data capture, secure storage, access to high-quality integrated datasets, and expert statistical consultation. Through these resources, the DMSC directly facilitates the CNTN goals of advancing the careers of junior investigators, expanding the neuroscience and research infrastructure in Nevada, and enhancing the understanding of neurodegenerative diseases (NDD). In Phase 1 of the COBRE award, the DMSC adopted OpenClinica, an open-sourced electronic data capture platform, to construct a distributed cloud- based data entry system that is 21 CFR Part 11 compliant. Throughout Phase 1, the Clinical and Translational Research Core (CTRC) of the CNTN established a cohort of individuals with AD or PD, and a group of demographically comparable cognitively normal (CN) older adults. A comprehensive data set generated by the CTRC, captured using OpenClinica, and maintained by the DMSC serves as a gateway for NDD researchers and collaborators who are not project leaders. Given the growth of the DMSC under the leadership of Joseph Lombardo in Phase 1, we intend to expand this Core during Phase 2. Director Lombardo will continue to lead the Core. Guogen Shan, PhD will serve as Associate Director for Biostatistics and will continue to work with COBRE and non-COBRE researchers to develop novel statistical tools to analyze neuroscience data. Justin B. Miller, PhD, a neuropsychologist with a deep interest in biomedical informatics, will be the Associate Director for Biomedical Informatics for Phase 2. During Phase 1 of the award, Dr. Miller worked under the mentorship of Gustavo Jiminez-Maggoria, Director of Informatics at the University of Southern California’s Alzheimer’s Therapeutic Research Institute, and has functioned as a liaison between DMSC faculty, the CTRC, and project leaders to ensure that the database functions smoothly for comprehensive data capture, organization, archiving, analysis, and export to non-COBRE research communities. In Phase 2 of the award, Dr. Miller will continue to work with project leaders and core directors to ensure that study data are of good quality, readily available, and accessible to project leaders. Additionally, in Phase 2, members of the DMSC will work extensively with the newly formed and recently integrated Brain Imaging Core (BIC). Phase 2 will require expansion and refinement of the DMSC’s digital infrastructure to facilitate integration of both raw image data and structured quantitative imaging data.

摘要/摘要 数据管理和统计核心（DMSC） 数据管理和统计核心（DMSC）是该中心不可或缺的组成部分 神经变性和转化神经科学（CNTN），为每个项目和核心提供数字 用于准确数据捕获，安全存储，访问高质量集成数据集的基础架构和专家 统计咨询。通过这些资源，DMSC直接促进了CNTN的目标 初级研究人员的职业，扩大内华达州的神经科学和研究基础设施，以及 增强对神经退行性疾病（NDD）的理解。在“毛”奖的第一阶段， DMSC采用开源的电子数据捕获平台Openclinica，以构建分布式云 - 基于21 CFR第11部分的数据输入系统符合第11部分。通过第1阶段，临床和翻译 CNTN的研究核心（CTRC）建立了一群具有AD或PD的个体，一组 人口统计学上可比的认知正常（CN）老年人。由 CTRC，使用Openclinica捕获，并由DMSC维护为NDD研究人员的网关 以及不是项目领导者的合作者。鉴于DMSC在约瑟夫的领导下的增长 伦巴多（Lombardo 核心。 PhD Guogen Shan将担任生物统计学副主任，并将继续与 毛病和非近代研究人员开发了分析神经科学数据的新型统计工具。贾斯汀·B（Justin B.） 米勒（Miller）博士是一名对生物医学信息感兴趣的神经心理学家，将担任副主任 第2阶段的生物医学信息学。在奖项的第1阶段，米勒博士在心态下工作 南加州大学阿尔茨海默氏症的信息学总监Gustavo Jiminez-Maggoria 治疗研究所，并在DMSC教职员工，CTRC和项目之间充当联络 领导者确保数据库正常运行，以捕获全面的数据捕获，组织，归档， 分析，并出口到非近代研究社区。在该奖项的第二阶段，米勒博士将继续 与项目负责人和核心主管合作，以确保研究数据质量良好，随时可用，并且 项目负责人可以访问。此外，在第2阶段中，DMSC的成员将与 新形成并最近整合的大脑成像核心（BIC）。第2阶段将需要扩展和完善 DMSC的数字基础架构，以促进原始图像数据和结构化定量的整合 成像数据。