Nevada Exploratory Alzheimer's Disease Research Center (NVEADRC)

内华达州探索性阿尔茨海默病研究中心 (NVEADRC)

• 批准号: 10450010
• 负责人: Justin Benjamin Miller
• 金额: $ 110.06万
• 依托单位: CLEVELAND CLINIC FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10450010
• 关键词: Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Awareness; Catchment Area; Characteristics; Clinic; Clinical Data; Collaborations; Collection; Communities; Data; Data Collection; Data Set; Dementia; Development; Diagnosis; Disease; Elderly; Enrollment; Ensure; Faculty; Fostering; Funding; Future; General Population; Geography; Goals; Government; Health Personnel; Health care facility; Healthcare; Impaired cognition; Incidence; Individual; Infrastructure; Knowledge; Lead; Literature; Longitudinal Studies; Mentors; Methodology; Mission; National Institute on Aging; Neurologist; Nevada; Nongovernmental Organizations; Participant; Patients; Persons; Physicians; Population; Population Growth; Primary Care Physician; Research; Research Personnel; Resources; Risk; Risk Factors; Rural; Rural Community; Rural Population; Source; Specimen; Standardization; Study Subject; Technology; Training; Transportation; Underserved Population; United States National Institutes of Health; Universities; Urban Community; Urban Population; authority; base; brain health; cohort; demented; dementia care; dementia risk; experience; frontier; health care disparity; health care quality; health care service; health disparity; human old age (65+); improved; interest; metropolitan; nervous system disorder; novel; operation; outreach; programs; ranpirnase; recruit; repository; retiree; rural area; rural healthcare; rural patients; rural setting; rural underserved; skills; smartphone based assessment; success; tool; treatment optimization; urban area

NVEADRC OVERALL SUMMARY Health and healthcare disparities in rural vs. urban areas are recognized for several decades, and this is particularly true for Alzheimer’s disease (AD) and Alzheimer’s disease related dementia (ADRD). Primary care physicians (PCPs) are rarely equipped with the skills and tools to diagnose the specific type of dementia their geriatric patients may be suffering. Because of possible long distances between rural areas and the nearest metropolitan area possessing expert dementia neurologists, some patients may never be diagnosed with dementia or may be misdiagnosed with the incorrect form of dementia. Previous Alzheimer Disease Research Centers (ADRCs) have explored rural risks and disparities for AD, but only as satellite programs rather than a major focus of their activities. Moreover, the literature on demented patients in rural areas is scarce and usually include only a small number of individuals with limited sets of biomedical data to be able to compare to datasets from the National Alzheimer’s Coordinating Center (NACC). Such gaps in healthcare offering and lack of reliable data on rural subjects is motivating us to create the Nevada Exploratory Alzheimer's Disease Research Center (NVEADRC). Our new Center is based on previous strong collaborations between the Las Vegas Lou Ruvo Center for Brain Health (LRBCH) and University of Nevada, Las Vegas (UNLV). In Aim 1, we will build the necessary infrastructure for the operations of our research enterprise. This includes the creation of novel methodologies and technologies to collect high-quality standardized clinical data in rural settings. In Aim 2, by utilizing the experience of our Outreach, Recruitment and Engagement Core we will foster our network of stakeholders, from government entities, to PCPs, down to rural patients themselves to make them feel that they own the NVEADRC project. In Aim 3, we will plan the transition from an exploratory stage to a full ADRC by demonstrating the feasibility of collecting longitudinal data from our rural cohort. By adding rural population information to the NACC set of data, our NVEADRC will provide novel resources that could be used by the broader AD/ADRD research community, which will significantly contribute to the overall mission of the ADRC network.

NVEADRC总体 摘要 几十年来，人们认识到农村和城市地区的健康和医疗保健差距，这是 尤其适用于阿尔茨海默病(AD)和阿尔茨海默病相关痴呆症(ADRD)。初级保健 医生(PCP)很少具备诊断特定类型痴呆症的技能和工具 老年患者可能正在遭受痛苦。因为农村地区和最近的城市之间可能有很远的距离 大都会地区拥有痴呆症神经学家专家，一些患者可能永远不会被诊断出患有痴呆症 痴呆症或可能被误诊为不正确形式的痴呆症。阿尔茨海默病研究进展 中心(ADRC)探索了AD的农村风险和差距，但仅作为卫星计划，而不是 他们活动的主要重点。此外，有关农村地区痴呆症患者的文献很少，通常 包括仅具有有限生物医学数据集合以能够与数据集进行比较的少数个体 来自国家阿尔茨海默氏症协调中心(NACC)。医疗保健提供方面的这种差距，以及缺乏可靠的 关于农村受试者的数据正在激励我们创建内华达州探索性阿尔茨海默病研究中心 (NVEADRC)。我们的新中心是基于拉斯维加斯Lou Ruvo之前的强大合作 脑健康中心(LRBCH)和内华达大学拉斯维加斯分校(UNLV)。在目标1中，我们将构建 为我们的研究企业的运营提供必要的基础设施。这包括小说的创作 在农村地区收集高质量标准化临床数据的方法和技术。在目标2中，由 利用我们的外联、招聘和参与核心的经验，我们将促进我们的网络 利益相关者，从政府实体到初级保健医生，一直到农村患者本身，让他们感觉到他们 拥有NVEADRC项目。在目标3中，我们将计划从探索阶段过渡到全面的亚洲发展研究中心，具体步骤如下 论证了从我国农村队列中收集纵向数据的可行性。通过增加农村人口 信息到NACC数据集，我们的NVEADRC将提供新的资源，可供更广泛的 AD/ADRD研究界，这将对ADRC网络的总体使命作出重大贡献。

项目成果

Inflammatory cytokine levels implicated in Alzheimer's disease moderate the effects of sex on verbal memory performance.

• DOI: 10.1016/j.bbi.2020.12.001
• 发表时间: 2021-07
• 期刊: Brain, behavior, and immunity
• 作者: Caldwell JZK;Kinney JW;Ritter A;Salazar A;Wong CG;Cordes D;Slavich GM
• 通讯作者: Slavich GM

Value-Generating Exploratory Trials in Neurodegenerative Dementias.

• DOI: 10.1212/wnl.0000000000011774
• 发表时间: 2021-05-18
• 期刊: Neurology
• 影响因子: 9.9
• 作者: Friedman LG;McKeehan N;Hara Y;Cummings JL;Matthews DC;Zhu J;Mohs RC;Wang D;Hendrix SB;Quintana M;Schneider LS;Grundman M;Dickson SP;Feldman HH;Jaeger J;Finger EC;Ryan JM;Niehoff D;Dickinson SL;Markowitz JT;Owen M;Travaglia A;Fillit HM
• 通讯作者: Fillit HM

The role of basket trials in drug development for neurodegenerative disorders.

• DOI: 10.1186/s13195-022-01015-6
• 发表时间: 2022-05-25
• 期刊: Alzheimer's research & therapy

Potential beneficial effects of masupirdine (SUVN-502) on agitation/aggression and psychosis in patients with moderate Alzheimer's disease: Exploratory post hoc analyses.

• DOI: 10.1002/gps.5813
• 发表时间: 2022-10
• 期刊: INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
• 影响因子: 4
• 作者: Nirogi, Ramakrishna;Jayarajan, Pradeep;Benade, Vijay;Shinde, Anil;Goyal, Vinod Kumar;Jetta, Satish;Ravula, Jyothsna;Abraham, Renny;Grandhi, Venkata Ramalingayya;Subramanian, Ramkumar;Pandey, Santosh Kumar;Badange, Rajesh Kumar;Mohammed, Abdul Rasheed;Jasti, Venkat;Ballard, Clive;Cummings, Jeffrey
• 通讯作者: Cummings, Jeffrey

Drug Development for Psychotropic, Cognitive-Enhancing, and Disease-Modifying Treatments for Alzheimer's Disease.

• DOI: 10.1176/appi.neuropsych.20060152
• 发表时间: 2021
• 期刊: The Journal of neuropsychiatry and clinical neurosciences
• 作者: Cummings J