Nevada Exploratory Alzheimer's Disease Research Center (NVEADRC)

内华达州探索性阿尔茨海默病研究中心 (NVEADRC)

• 批准号: 10220839
• 负责人: Justin Benjamin Miller
• 金额: $ 108.41万
• 依托单位: CLEVELAND CLINIC FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10220839
• 关键词: Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Awareness; Catchment Area; Characteristics; Clinic; Clinical Data; Collaborations; Collection; Communities; Data; Data Collection; Data Set; Dementia; Development; Diagnosis; Disease; Elderly; Enrollment; Ensure; Faculty; Fostering; Funding; Future; General Population; Geography; Goals; Government; Health Personnel; Health care facility; Healthcare; Impaired cognition; Incidence; Individual; Infrastructure; Knowledge; Lead; Literature; Longitudinal Studies; Mentors; Methodology; Mission; National Institute on Aging; Neurologist; Nevada; Nongovernmental Organizations; Participant; Patients; Physicians; Population; Population Growth; Primary Care Physician; Research; Research Personnel; Resources; Risk; Risk Factors; Rural; Rural Community; Rural Population; Source; Specimen; Standardization; Study Subject; Technology; Training; Transportation; Underserved Population; United States National Institutes of Health; Universities; Urban Community; Urban Population; authority; base; brain health; cohort; demented; dementia care; dementia risk; experience; frontier; health care disparity; health care quality; health care service; health disparity; human old age (65+); improved; interest; metropolitan; nervous system disorder; novel; operation; outreach; programs; ranpirnase; recruit; repository; retiree; rural area; rural healthcare; rural patients; rural setting; rural underserved; skills; smartphone based assessment; success; tool; treatment optimization; urban area

NVEADRC OVERALL SUMMARY Health and healthcare disparities in rural vs. urban areas are recognized for several decades, and this is particularly true for Alzheimer’s disease (AD) and Alzheimer’s disease related dementia (ADRD). Primary care physicians (PCPs) are rarely equipped with the skills and tools to diagnose the specific type of dementia their geriatric patients may be suffering. Because of possible long distances between rural areas and the nearest metropolitan area possessing expert dementia neurologists, some patients may never be diagnosed with dementia or may be misdiagnosed with the incorrect form of dementia. Previous Alzheimer Disease Research Centers (ADRCs) have explored rural risks and disparities for AD, but only as satellite programs rather than a major focus of their activities. Moreover, the literature on demented patients in rural areas is scarce and usually include only a small number of individuals with limited sets of biomedical data to be able to compare to datasets from the National Alzheimer’s Coordinating Center (NACC). Such gaps in healthcare offering and lack of reliable data on rural subjects is motivating us to create the Nevada Exploratory Alzheimer's Disease Research Center (NVEADRC). Our new Center is based on previous strong collaborations between the Las Vegas Lou Ruvo Center for Brain Health (LRBCH) and University of Nevada, Las Vegas (UNLV). In Aim 1, we will build the necessary infrastructure for the operations of our research enterprise. This includes the creation of novel methodologies and technologies to collect high-quality standardized clinical data in rural settings. In Aim 2, by utilizing the experience of our Outreach, Recruitment and Engagement Core we will foster our network of stakeholders, from government entities, to PCPs, down to rural patients themselves to make them feel that they own the NVEADRC project. In Aim 3, we will plan the transition from an exploratory stage to a full ADRC by demonstrating the feasibility of collecting longitudinal data from our rural cohort. By adding rural population information to the NACC set of data, our NVEADRC will provide novel resources that could be used by the broader AD/ADRD research community, which will significantly contribute to the overall mission of the ADRC network.

NVEADRC总体 总结 几十年来，人们一直认识到农村与城市地区的健康和医疗保健差距， 特别是对于阿尔茨海默病（AD）和阿尔茨海默病相关痴呆（ADRD）。初级保健 医生（PCP）很少配备技能和工具来诊断特定类型的痴呆症， 老年患者可能会遭受痛苦。由于农村地区和最近的城市之间可能距离很远， 大都市地区拥有专家痴呆神经学家，一些患者可能永远不会被诊断为痴呆症。 痴呆症或可能被误诊为痴呆症的不正确形式。阿尔茨海默病研究 中心（ADRC）已经探索了AD的农村风险和差异，但只是作为卫星计划，而不是一个 其活动的重点。此外，关于农村地区痴呆症患者的文献很少，通常 包括具有能够与数据集进行比较有限的生物医学数据集的少数个体 国家阿尔茨海默氏症协调中心（NACC）医疗保健服务方面的差距以及缺乏可靠的 关于农村受试者的数据激励我们创建了内华达州探索性阿尔茨海默病研究中心 （NVEADRC）。我们的新中心是基于以前的强大合作之间的拉斯维加斯卢鲁沃 脑健康中心（LRBCH）和内华达州大学，拉斯维加斯（UNLV）。在目标1中，我们将建立 为我们的研究企业提供必要的基础设施。这包括小说的创作 在农村地区收集高质量标准化临床数据的方法和技术。在目标2中， 利用我们的推广，招聘和参与核心的经验，我们将促进我们的网络， 利益相关者，从政府实体，到PCP，再到农村患者自己，让他们觉得他们 拥有NVEADRC项目。在目标3中，我们将计划从探索阶段过渡到全面的ADRC， 证明了从我们的农村队列中收集纵向数据的可行性。通过增加农村人口 通过将这些信息与NACC数据集相结合，我们的NVEADRC将提供新的资源， AD/ADRD研究社区，这将大大有助于ADRC网络的整体使命。