Nevada Exploratory Alzheimer's Disease Research Center (NVEADRC)

内华达州探索性阿尔茨海默病研究中心 (NVEADRC)

• 批准号: 10220839
• 负责人: Justin Benjamin Miller
• 金额: $ 108.41万
• 依托单位: CLEVELAND CLINIC FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10220839
• 关键词: Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Awareness; Catchment Area; Characteristics; Clinic; Clinical Data; Collaborations; Collection; Communities; Data; Data Collection; Data Set; Dementia; Development; Diagnosis; Disease; Elderly; Enrollment; Ensure; Faculty; Fostering; Funding; Future; General Population; Geography; Goals; Government; Health Personnel; Health care facility; Healthcare; Impaired cognition; Incidence; Individual; Infrastructure; Knowledge; Lead; Literature; Longitudinal Studies; Mentors; Methodology; Mission; National Institute on Aging; Neurologist; Nevada; Nongovernmental Organizations; Participant; Patients; Physicians; Population; Population Growth; Primary Care Physician; Research; Research Personnel; Resources; Risk; Risk Factors; Rural; Rural Community; Rural Population; Source; Specimen; Standardization; Study Subject; Technology; Training; Transportation; Underserved Population; United States National Institutes of Health; Universities; Urban Community; Urban Population; authority; base; brain health; cohort; demented; dementia care; dementia risk; experience; frontier; health care disparity; health care quality; health care service; health disparity; human old age (65+); improved; interest; metropolitan; nervous system disorder; novel; operation; outreach; programs; ranpirnase; recruit; repository; retiree; rural area; rural healthcare; rural patients; rural setting; rural underserved; skills; smartphone based assessment; success; tool; treatment optimization; urban area

NVEADRC OVERALL SUMMARY Health and healthcare disparities in rural vs. urban areas are recognized for several decades, and this is particularly true for Alzheimer’s disease (AD) and Alzheimer’s disease related dementia (ADRD). Primary care physicians (PCPs) are rarely equipped with the skills and tools to diagnose the specific type of dementia their geriatric patients may be suffering. Because of possible long distances between rural areas and the nearest metropolitan area possessing expert dementia neurologists, some patients may never be diagnosed with dementia or may be misdiagnosed with the incorrect form of dementia. Previous Alzheimer Disease Research Centers (ADRCs) have explored rural risks and disparities for AD, but only as satellite programs rather than a major focus of their activities. Moreover, the literature on demented patients in rural areas is scarce and usually include only a small number of individuals with limited sets of biomedical data to be able to compare to datasets from the National Alzheimer’s Coordinating Center (NACC). Such gaps in healthcare offering and lack of reliable data on rural subjects is motivating us to create the Nevada Exploratory Alzheimer's Disease Research Center (NVEADRC). Our new Center is based on previous strong collaborations between the Las Vegas Lou Ruvo Center for Brain Health (LRBCH) and University of Nevada, Las Vegas (UNLV). In Aim 1, we will build the necessary infrastructure for the operations of our research enterprise. This includes the creation of novel methodologies and technologies to collect high-quality standardized clinical data in rural settings. In Aim 2, by utilizing the experience of our Outreach, Recruitment and Engagement Core we will foster our network of stakeholders, from government entities, to PCPs, down to rural patients themselves to make them feel that they own the NVEADRC project. In Aim 3, we will plan the transition from an exploratory stage to a full ADRC by demonstrating the feasibility of collecting longitudinal data from our rural cohort. By adding rural population information to the NACC set of data, our NVEADRC will provide novel resources that could be used by the broader AD/ADRD research community, which will significantly contribute to the overall mission of the ADRC network.

NVEADRC总体上 概括 农村与城市地区的健康和医疗保健差异已被认可数十年，这就是 阿尔茨海默氏病（AD）和阿尔茨海默氏病有关的痴呆症（ADRD）尤其如此。初级保健 医师（PCP）很少配备能够诊断特定类型痴呆类型的技能和工具 老年患者可能正在遭受痛苦。由于可能的粗糙区域和最近的长距离 具有专家痴呆神经科医生的大都市地区，一些患者可能永远不会被诊断出患有 痴呆症或可能以不正确的痴呆形式被诊断出来。以前的阿尔茨海默氏病研究 中心（ADRC）探索了广告的粗糙风险和分布，但仅作为卫星计划而不是 他们的活动的主要重点。此外，关于粗糙地区痴呆患者的文献很少，通常 仅包括少数具有有限生物医学数据集有限的个人，以便能够与数据集进行比较 来自国家阿尔茨海默氏症协调中心（NACC）。医疗保健提供的差距和缺乏可靠的 关于粗糙主题的数据激励我们创建内华达州探索性阿尔茨海默氏病研究中心 （nveadrc）。我们的新中心基于拉斯维加斯Lou Ruvo之间以前的强大合作 大脑健康中心（LRBCH）和内华达大学拉斯维加斯大学（UNLV）。在AIM 1中，我们将建立 我们研究企业运营的必要基础设施。这包括创作小说 在粗糙环境中收集高质量标准化临床数据的方法和技术。在AIM 2中，由 利用我们的外展，招聘和参与核心的经验，我们将促进我们的网络 利益相关者，从政府实体到PCP，再到粗糙的患者本身，使他们感到自己 拥有NVEADRC项目。在AIM 3中，我们将计划从探索阶段到完整ADRC的过渡 证明了从我们的农村队列中收集纵向数据的可行性。通过增加农村人口 向NACC数据集的信息，我们的NVEADRC将提供更广泛使用的新型资源 AD/ADRD研究社区，将为ADRC网络的整体任务做出重大贡献。