NVEADRC Administrative Core (AC)

NVEADRC 行政核心 (AC)

• 批准号: 10220840
• 负责人: Justin Benjamin Miller
• 金额: $ 32.92万
• 依托单位: CLEVELAND CLINIC FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10220840
• 关键词: Address; Advisory Committees; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Automobile Driving; Awareness; Biological Markers; Brain imaging; Budgets; Caring; Charge; Clinic; Clinical; Clinical Trials; Collaborations; Communication; Communities; Competence; Data; Data Analyses; Data Security; Dementia; Education; Educational Activities; Elderly; Ensure; Event; Faculty; Feedback; Female; Fostering; Future; Goals; Grant; Health Personnel; Healthcare; Human; Individual; Infrastructure; International; Lead; Leadership; Medical; Mission; Modeling; Monitor; Neurodegenerative Disorders; Neurosciences; Nevada; Pamphlets; Participant; Patient Care; Patients; Performance; Pilot Projects; Policies; Population; Preparation; Procedures; Productivity; Research; Research Activity; Research Personnel; Resources; Running; Rural; Rural Community; Safety; Secure; Site; Specific qualifier value; Specimen; Suggestion; Supervision; Technology; Telemedicine; Training and Education; United States National Institutes of Health; Universities; Work; authority; base; brain health; career development; cohort; data exchange; data management; education research; experience; health care disparity; human subject; improved; learning materials; meetings; multidisciplinary; neuropathology; novel; operation; outreach; programs; ranpirnase; recruit; rural area; rural disparities; rural healthcare; statistics; teleneurology; teleneuropsychology; women faculty

NVEADRC ADMINISTRATIVE CORE (AC) SUMMARY Our Nevada Exploratory Alzheimer’s Disease Research Center (NVEADRC) is a novel and ambitious research endeavor aiming at filling a gap from existing ADRCs, which is to collect and share high-quality biomedical data and specimens from individuals suffering dementia from rural areas. Like for all novel enterprises, the NVEADRC needs a fully committed leadership to steer and prioritize its activities from the beginning of the project. For this, we have selected strong leaders with prior ADRC experience to lead the project. The Administrative Core (AC) is the driving entity for our NVEADRC. It will oversee the research and educational activities of a strong multidisciplinary team composed of investigators from the Cleveland Clinic Lou Ruvo Center for Brain Health (LRBCH) and University of Nevada, Las Vegas (UNLV). Most of the investigators are already part of other collaborative projects, which will greatly facilitate communication between the different Cores early on since most actors in the enterprise are already aware of the requirements for a successful large collaborative project. We have set four strategic aims for the AC. In Aim 1, the AC will set up Cores operations with the goal of running this project over several decades. For this, the AC will call monthly meetings with all Core leaders to address progress and challenges. The meeting minutes will be sent to all NVEADRC actors to collect feedback for improvement and suggestions on novel directions. The AC will assure the successful integration of participating rural sites and investigators, and promote collaborations within the ADRC network. The AC will coordinate the review and guidance of the NVEADRC by integrating the feedback from an internal and an external advisory committee. In Aim 2, the AC will work on professionalizing rural dementia healthcare and scientific research by determining the specific needs of rural medical professionals in neurodegenerative disorders education to create specific courses and materials (e.g. brochures and videos) for large broadcasting in NV and beyond. Moreover, by fostering the career development of female faculty the AC wants to offer a transformative experience to build a pipeline of future female ADRC collaborators and project leaders. In Aim 3, we will leverage our community connections to inform patients about clinical trials and to recruit rural subjects in our clinical cohort. In Aim 4, the AC will develop the necessary assessment procedures for compliance and to monitor performance. This includes compliance with human subjects, scientific integrity, information security and financial policy requirements from NIH. In addition, the AC will create the procedures for Core assessments to gauge progress based on pre- determined annual goals. Very importantly, the AC is in charge of the successful transfer of the data captured from our rural subjects to the National Alzheimer’s Coordinating Center (NACC). Under its strong leadership, our team is ready to tackle this human challenge in order to dramatically improve dementia research and healthcare in the State of Nevada.

NVEADRC行政核心（AC） 总结 我们的内华达州探索性阿尔茨海默病研究中心（NVEADRC）是一项新颖而雄心勃勃的研究 奋进填补现有ADRC的空白，即收集和共享高质量的生物医学数据 以及来自农村地区的痴呆症患者的样本。像所有的新企业一样，NVEADRC 从项目一开始就需要一个全心全意的领导，指导和优先安排其活动。为此， 我们选择了具有ADRC经验的强有力的领导人来领导该项目。行政核心（AC） 是我们NVEADRC的驱动实体。它将监督一个强大的研究和教育活动， 由克利夫兰诊所卢鲁沃脑健康中心的研究人员组成的多学科团队 （LRBCH）和内华达州大学，拉斯维加斯（UNLV）。大多数调查人员已经参与了其他 合作项目，这将大大促进不同核心之间的沟通，因为大多数 企业中的参与者已经意识到成功的大型协作项目的要求。我们有 为AC设定了四个战略目标。在目标1中，AC将设置核心操作，目标是运行此 几十年来的项目。为此，AC将与所有核心领导人召开月度会议，以解决进展问题 和挑战会议记录将发送给NVEADRC的所有参与者，以收集改进反馈 和新方向的建议。AC将确保参与的农村站点成功整合， 调查员，并促进ADRC网络内的合作。AC将协调审查， 通过整合内部和外部咨询委员会的反馈，对NVEADRC进行指导。在 目标2，AC将致力于农村痴呆症医疗保健和科学研究的专业化， 农村医疗专业人员在神经退行性疾病教育的具体需求，以创建具体的 为内华达州及其他地区的大型广播提供课程和材料（例如小册子和视频）。此外，由 促进女教师的职业发展，AC希望提供一种变革性的经验， 未来的女性ADRC合作者和项目领导者的管道。在目标3中，我们将利用我们的社区 我们还建立了联系，以便向患者通报临床试验情况，并在我们的临床队列中招募农村受试者。目标4： 审计委员会将制定必要的合规评估程序，并监督绩效。这包括 符合人类受试者、科学完整性、信息安全和财务政策要求， 国家卫生研究院此外，咨询委员会还将制定核心评估程序，根据预先评估结果衡量进展情况， 确定年度目标。非常重要的是，AC负责成功传输捕获的数据 从我们的农村受试者到国家阿尔茨海默氏症协调中心（NACC）。在其坚强领导下， 该团队已准备好应对这一人类挑战，以显着改善痴呆症研究和医疗保健 在内华达州。