Modification of Threat Interpretation Bias to Reduce Anxiety in Neurodegenerative Movement Disorders

改变威胁解释偏差以减少神经退行性运动障碍的焦虑

• 批准号: 10577294
• 负责人: Jessie Sellers Gibson
• 金额: $ 15.23万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-20 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10577294
• 关键词: Address; Adult; American; Anxiety; Anxiety Disorders; Behavior Therapy; Benign; Breathing; COVID-19 pandemic; Caregiver Burden; Caregivers; Case Series; Clinical; Clinical Trials; Clinical Trials Design; Cognition; Cognitive; Cognitive Therapy; Collaborations; Communities; Data; Development; Diagnosis; Doctor of Philosophy; Environment; Evaluation; Evidence based treatment; FDA approved; Feedback; Foundations; Gait abnormality; Goals; Home; Huntington Disease; Individual; Internet; Intervention; Interview; Knowledge; Leadership; Measurement; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; Modification; Mood Disorders; Movement; Movement Disorders; Nerve Degeneration; Neurodegenerative Disorders; Nurses; Nursing Schools; Online Systems; Parkinson Disease; Participant; Patient Recruitments; Patients; Persons; Pharmaceutical Preparations; Phase; Physical activity; Population; Prevalence; Process; Protocols documentation; Provider; Quality of life; Recommendation; Research; Research Personnel; Sampling; Scientist; Strategic Planning; Subgroup; Symptoms; Testing; Thinking; Time; Training; Training Programs; Transportation; Universities; Virginia; Waiting Lists; Work; anxiety reduction; anxiety symptoms; anxious; career; career development; cognitive training; cost; design; digital; experience; flexibility; follow-up; functional status; human centered design; ideation; improved; improved outcome; innovative technologies; neuropsychiatric symptom; novel; off-label use; programs; prototype; psychologic; recruit; research and development; self-reported anxiety; sex; skills; stakeholder perspectives; success; symptom management; symptom treatment; therapy development; trait

PROJECT SUMMARY: The proposed K23 award will prepare Dr. Jessie Gibson, PhD, RN, AGPCNP-BC to become an independent investigator developing interventions for neuropsychiatric symptom management in neurodegenerative disease. Dr. Gibson’s clinical and research experiences have provided a foundation in identification, measurement, and effects of neuropsychiatric symptoms in Huntington’s disease (HD) and Parkinson’s disease (PD). The proposed research plan will prepare Dr. Gibson to take the next steps toward investigating treatment for these symptoms in independent clinical trials. Anxiety symptoms are extremely prevalent in HD and PD, causing significant burden for patients and caregivers. Unfortunately, there is limited evidence for how to treat these symptoms. Experts recommend use of psychological interventions to treat anxiety symptoms in HD and PD, but there have been few rigorous studies to support these recommendations. Cognitive bias modification for interpretation bias (CBM-I) paradigms address negative interpretation biases by training participants to (re)interpret ambiguous, potentially threatening situations in more benign ways to make anxious thinking more flexible. Our preliminary work has demonstrated feasibility of web-based CBM-I in this population and identified the need to adapt CBM-I programs to meet the needs of individuals with movement disorders. Our current objective is to determine whether a web-based cognitive bias modification for interpretation bias (CBM-I) intervention can reduce anxiety in PD and HD. Thus, we aim to: 1) gather stakeholder perspectives and 2) develop a web-based CBM-I intervention tailored to individuals with neurodegenerative movement disorders (MindTrails-Movement), then 3) evaluate target engagement and preliminary efficacy of MindTrails-Movement for reducing interpretation bias and anxiety symptoms in HD and PD. To carry out these aims and prepare Dr. Gibson to become a national leader in developing interventions for neuropsychiatric symptom management in neurodegenerative disease, she will work with an expert mentoring team led by Dr. Bethany Teachman, and including co-mentors Drs. Madaline Harrison, Carol Manning, Jeanne Alhusen, and Guofen Yan. Training experiences will support Dr. Gibson’s career development goals to: 1) cultivate skills to develop behavioral interventions using human-centered design; 2) develop expertise in clinical trial design and implementation; 3) establish advanced knowledge of mechanisms that maintain mood and anxiety disorders; and 4) develop leadership and grantsmanship skills and establish collaborations to prepare for a successful career as an independent nurse scientist. University of Virginia provides the ideal environment to achieve these research and career development goals, as home to a world- class nursing school, Huntington’s Disease Center of Excellence, American Parkinson’s Disease Association Advanced Center for Research, and the Program for Anxiety, Cognition and Treatment (PACT) lab- all of which are critical to the success of this proposal.

项目摘要：拟议的K23奖项将使AGPCNP-BC的Jessie Gibson博士、博士、RN准备好 成为一名独立的研究员，开发神经精神症状管理的干预措施 神经退行性疾病。吉布森博士的临床和研究经验为 亨廷顿病(HD)神经精神症状的识别、测量和影响 帕金森氏病(PD)。拟议的研究计划将为吉布森博士采取下一步行动做好准备 在独立的临床试验中调查这些症状的治疗方法。焦虑症状非常严重 在HD和PD中普遍存在，给患者和照顾者带来巨大负担。不幸的是，有有限的 如何治疗这些症状的证据。专家建议使用心理干预来治疗 HD和PD的焦虑症状，但很少有严格的研究支持这些建议。 认知偏差对口译偏差的修正(CBM-I)范式通过以下方式解决负面口译偏差 培训参与者以更温和的方式(重新)解释模棱两可、具有潜在威胁的情况，以使 焦虑的思维更加灵活。我们的初步工作证明了基于Web的CBM-I在这方面的可行性 并确定了需要调整CBM-I方案以满足有行动的个人的需求 精神错乱。我们目前的目标是确定基于网络的认知偏差修改是否 口译偏倚(CBM-I)干预可以降低PD和HD患者的焦虑。因此，我们的目标是：1)收集 利益相关者观点和2)开发基于Web的CBM-I干预措施，该干预措施适用于具有 神经退行性运动障碍(思维轨迹-运动)，然后3)评估目标投入和 意念-运动对减少HD和AD患者口译偏差和焦虑症状的初步疗效 警察。为了实现这些目标，并使吉布森博士做好准备，成为开发干预措施的国家领导者 对于神经退行性疾病的神经精神病学症状管理，她将与一位专家合作 由Bathany Teachman博士领导的导师团队，包括共同导师Madaline Harison博士、Carol 曼宁、珍妮·阿尔胡森和严国芬。培训经验将为吉布森博士的职业生涯提供支持 发展目标：1)培养使用以人为中心的设计开发行为干预措施的技能；2) 培养临床试验设计和实施方面的专业知识；3)建立先进的机制知识 保持情绪和焦虑症；以及4)发展领导和仁慈的技能，并建立 为作为独立护士科学家的成功职业生涯做准备的合作。弗吉尼亚大学 为实现这些研究和职业发展目标提供理想的环境，作为世界的家园- 班级护理学校，亨廷顿病卓越中心，美国帕金森病协会 高级研究中心和焦虑、认知和治疗计划(PACT)实验室-所有这些 对这项提议的成功至关重要。