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Genomics and Bioinformatics Core

基因组学和生物信息学核心

基本信息

批准号：
10237682
负责人：
Eric J. Vilain
金额：
$ 15.69万
依托单位：
CHILDREN'S RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-21 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10237682
关键词：
Adopted Behavioral Bioinformatics Biological Categories Cell physiology Cells ChIP-seq Clinical Clinical Data Clinical Research Collaborations Complex DNA sequencing Data Development Diagnosis Diagnostic District of Columbia Equipment Etiology Experimental Designs Gene Expression Genes Genetic Genetic Diseases Genome Genomics Individual Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Interdisciplinary Study International Knowledge Methods Methylation Microanatomy Mission Molecular Monitor Neonatal Brain Injury Neurodevelopmental Disorder Optics Outcome Patients Pattern Phenotype Physiology Population Prevention Research Research Design Research Personnel Resolution Role Structure Techniques Technology Therapeutic Intervention Training Training Support Training and Education Translational Research Translations Variant base bench to bedside biomedical data science clinical phenotype computerized tools cost effective design early-career faculty epigenetic regulation epigenome experience fetal genome sequencing genomic data genomic signature improved insight large datasets molecular marker multidisciplinary neurodevelopment novel transcriptomics

项目摘要

Genomics and Bioinformatics Core (GBC): PROJECT SUMMARY/ABSTRACT The Genomics and Bioinformatics Core (GBC) delivers cost-effective analytical genomics solutions and bioinformatics analyses for intellectual and developmental disabilities (IDD) researchers. The objective of the GBC is to maximize the potential for researchers to develop new insights, diagnostics and therapeutic interventions for individuals with IDD by removing obstacles for leveraging genomic methods. The GBC has a dedicated staff led by internationally known investigators with an established track record in multidisciplinary research with a focus in genomics and bioinformatics. The genomics group of the Core provides equipment, expertise and training to support efficient utilization of genomics technologies. The bioinformatics group develops computational tools for omics data, designs best practices for utilizing large datasets, and provides training in biomedical data sciences. Advances in genome sequencing technologies enable researchers to identify changes that relate to IDD. The aims of the GBC are to provide access to, and training in, cutting edge techniques and technologies that can result in insights into the genetic basis of IDDs, to capture high resolution single cell level data of gene expression that contribute to development and dysregulation in IDDS and to maximize the impact of genomic information in understanding IDD by integrating genomic data with clinical, behavioral and pathophysical knowledge. In this way, the GBC will contribute to the understanding of the molecular physiology of IDDs and create new opportunities to develop diagnostics and therapeutic interventions.

基因组学和生物信息学核心（GBC）：项目摘要/摘要