Novel Early Detection Strategy for Liver Cancer using Hepatitis B Splice Variants to Expediate Diagnosis and Improve Treatment Outcome

乙肝病毒(乙肝病毒)导致肝癌，这是仅有的几种发病率上升的癌症之一。我们已经证明，被称为剪接变体的较小版本的乙肝病毒与肝癌的相关性甚至更强-剪接变体水平较高的人患肝癌的可能性是后者的3倍以上。我们将通过深入研究剪接变体如何改变病毒和宿主细胞来促进肝癌，从而找出原因。

Hepatitis B virus (HBV) causes liver cancer, which is one of the only cancers that is increasing in prevalence. We have shown that smaller versions of HBV, termed splice variants, are even more strongly associated with liver cancer- people with higher levels of the splice variants were over 3 times more likely to have liver cancer. We will find out why, by thoroughly studying how the splice variants alter the virus and the host cell to promote liver cancer.