RNA-mediated control of HIV gene expression

目前的联合抗病毒治疗不能治愈HIV感染，因为携带潜伏HIV DNA的长寿T细胞在药物被移除时会重新引发感染。我们将研究HIV遗传密码中控制潜伏HIV蛋白表达的元素。对这些HIV RNA元件的结构和功能以及与它们相互作用的病毒和宿主细胞因子的详细分子理解将揭示潜伏HIV治疗的新靶点。

Current combination antiviral therapy can't cure an HIV infection because long-lived T-cells carrying latent HIV DNA can rekindle the infection when drugs are removed. We will study elements in HIV genetic code that control expression of HIV proteins from latent HIV. A detailed molecular understanding of the structure and function of these HIV RNA elements and the viral and host cell factors that interact with them will expose new targets for therapy of latent HIV.