Investigating the host determinants of viral clearance versus collateral pathology in chronic infection

乙肝病毒已经感染了20多亿人。一些人控制了这种病毒，但它仍然无法治愈，而且有终身罹患肝癌的风险。了解宿主细胞如何与病毒相互作用，细胞用来试图消除病毒的机制，以及病毒用来破坏这些反应的机制，将提供可能导致治疗的见解。潜在的治疗方法可能适用于其他感染，如艾滋病毒-1和结核病。

Hepatitis B virus has infected over 2 billion people. Some people control the virus but it remains incurable and there is a lifelong risk of liver cancer. Understanding how host cells interact with the virus, the mechanisms the cells use in an attempt to eliminate the virus and the mechanisms the virus uses to sabotage these responses, will provide insights that could lead to therapies. Potential therapies could be applicable to other infections like HIV-1 and tuberculosis.