Longitudinal Associations Between Frailty and Lower Urinary Tract Symptoms in Older Men
老年男性虚弱与下尿路症状之间的纵向关联
基本信息
- 批准号:10263308
- 负责人:
- 金额:$ 15.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-15 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:Activities of Daily LivingAgeAgingAwardBenign Prostatic HypertrophyBladderChronicCohort AnalysisCommunitiesCross-Sectional StudiesDataDevelopmentDiabetes MellitusElderlyEpidemiologistEtiologyEvaluationFoundationsFractureFrequenciesFutureGeriatric AssessmentGeriatricsGoalsHealthIncontinenceIndividualInternationalInternistInterventionKnowledgeLeadLongitudinal StudiesMeasurementMeasuresMedicalMentorshipModelingMuscleMuscular AtrophyNocturiaOutcomePatientsPersonal SatisfactionPharmaceutical PreparationsPhenotypePhysical FunctionPhysical activityPolyuriaPrimary Health CareProcessProspective cohort studyProstatePublic HealthQuality of lifeResearchResearch DesignResearch PersonnelRisk FactorsSeveritiesStreamSymptomsSyndromeTestingUrologistUrologyWorkalternative treatmentassociated symptomcardiovascular healthcareercohortcomorbidityexhaustionexperiencefall riskfallsfollow-upfrailtyfunctional disabilityfunctional outcomeshealth related quality of lifeholistic approachhuman old age (65+)improvedindexingindividualized medicineinnovationlower urinary tract symptomsmenmicturition urgencymodifiable riskmortalitymultidisciplinarynovelolder menosteoporosis with pathological fracturepoor sleeppreventprospectivepsychologicroutine screeningside effectsleep qualitysymptom treatmenturinaryurologic
项目摘要
PROJECT SUMMARY/ABSTRACT
There is a fundamental knowledge gap and potential missed opportunity related to the current lack of
understanding about the relationship between lower urinary tract symptoms (LUTS) and frailty among older
men. Older men with LUTS are more likely to suffer from falls, fractures, functional impairment, poor health-
related quality of life, and mortality, but our current LUTS treatments do not target these outcomes. Further, we
have limited understanding of how frailty and other systemic processes of aging, which are strongly associated
with functional impairment, may contribute to the development of LUTS.
Our long-term goal is to improve health-related quality of life and functional outcomes among older men with
LUTS by creating a novel holistic framework for understanding the contribution of non-urologic and aging
factors to the development of LUTS as well as the impact of LUTS on frailty and functional outcomes. The
objective of this application is to evaluate the direction and strength of longitudinal associations between LUTS
and frailty in order to identify preceding and potentially modifiable risk factors. Our central hypothesis is that the
relationship between LUTS and frailty is bidirectional, such that LUTS are independently associated with
worsening frailty and that frailty is independently associated with worsening LUTS.
This hypothesis will be tested by leveraging the prospective, observational Osteoporotic Fractures in Men
(MrOS) Study to pursue the following specific aims: Aim 1) To determine the longitudinal association between
frailty and worsening LUTS; and Aim 2) To determine the longitudinal association between LUTS severity and
worsening frailty. This project is innovative because it combines and leverages two previously distinct
conceptual models – it builds upon our prior work demonstrating the strong cross-sectional association
between LUTS and frailty to evaluate frailty as a previously unexplored predictor or mechanism of LUTS and
LUTS as an unexplored predictor or mechanism of frailty.
The proposed research is significant because a comprehensive evaluation of these longitudinal relationships is
needed in order to identify novel frailty or LUTS mechanisms and treatments as well as early frailty indicators.
For example, men with frailty-associated LUTS may require different interventions than the prostate and
bladder-focused therapies that are currently recommended. Alternatively, treatments for certain LUTS domains
may prevent or reverse frailty and subsequent functional impairment. This research will result in an improved
understanding of the potential bidirectional and reciprocal relationship of these conditions and will identify novel
mechanisms to inform the development of new interventions to improve or maintain health-related quality of life
and physical function among older men with LUTS.
项目总结/摘要
存在着根本性的知识差距,而且由于目前缺乏
了解老年人下尿路症状(LUTS)与虚弱的关系
男人患有LUTS的老年男性更容易发生福尔斯、骨折、功能障碍、健康状况不佳-
相关的生活质量和死亡率,但我们目前的LUTS治疗并不针对这些结果。我们还
对虚弱和其他系统性衰老过程的理解有限,
功能障碍,可能有助于发展下尿路症状。
我们的长期目标是改善老年男性的健康相关生活质量和功能结果,
LUTS通过创建一个新的整体框架,以了解非泌尿系统和衰老的贡献
影响LUTS发展的因素以及LUTS对虚弱和功能结局的影响。的
本申请的目的是评估LUTS之间纵向关联的方向和强度
和虚弱,以确定先前的和潜在的可改变的风险因素。我们的中心假设是,
LUTS和虚弱之间的关系是双向的,因此LUTS独立地与
虚弱恶化,虚弱与LUTS恶化独立相关。
该假设将通过利用前瞻性、观察性男性骨质疏松性骨折进行检验。
(MrOS)研究旨在实现以下具体目标:目标1)确定
目的2)确定LUTS严重程度与
虚弱恶化这个项目是创新的,因为它结合并利用了两个以前不同的
概念模型-它建立在我们先前的工作,证明了强有力的横截面关联
在LUTS和虚弱之间进行评估,以将虚弱作为先前未探索的LUTS预测因子或机制,
LUTS作为一个未探索的预测或脆弱的机制。
建议的研究是有意义的,因为这些纵向关系的综合评价是
为了确定新的虚弱或LUTS机制和治疗以及早期虚弱指标,
例如,患有虚弱相关LUTS的男性可能需要与前列腺不同的干预,
目前推荐的以膀胱为中心的治疗方法。或者,某些LUTS结构域的治疗
可以预防或逆转虚弱和随后的功能损害。这项研究将改善
了解这些条件的潜在双向和相互关系,并将确定新的
为制定新的干预措施提供信息的机制,以改善或维持与健康有关的生活质量
和身体功能的影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Scott Ryan Bauer其他文献
Scott Ryan Bauer的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Scott Ryan Bauer', 18)}}的其他基金
Prescription exercise for Older men with Urinary Disease (PROUD) pilot study
患有泌尿系统疾病的老年男性的处方练习(PROUD)试点研究
- 批准号:
10639885 - 财政年份:2023
- 资助金额:
$ 15.33万 - 项目类别:
Age-related changes in skeletal muscle and lower urinary tract symptoms in older adults
老年人骨骼肌和下尿路症状与年龄相关的变化
- 批准号:
10493395 - 财政年份:2021
- 资助金额:
$ 15.33万 - 项目类别:
Age-related changes in skeletal muscle and lower urinary tract symptoms in older adults
老年人骨骼肌和下尿路症状与年龄相关的变化
- 批准号:
10646356 - 财政年份:2021
- 资助金额:
$ 15.33万 - 项目类别:
Age-related changes in skeletal muscle and lower urinary tract symptoms in older adults
老年人骨骼肌和下尿路症状与年龄相关的变化
- 批准号:
10337785 - 财政年份:2021
- 资助金额:
$ 15.33万 - 项目类别:
Longitudinal Associations Between Frailty and Lower Urinary Tract Symptoms in Older Men
老年男性虚弱与下尿路症状之间的纵向关联
- 批准号:
10025786 - 财政年份:2020
- 资助金额:
$ 15.33万 - 项目类别:
相似国自然基金
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
- 批准号:JCZRQN202500010
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
- 批准号:2025JJ70209
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
- 批准号:
- 批准年份:2024
- 资助金额:0 万元
- 项目类别:面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
- 批准号:2023JJ50274
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
- 批准号:n/a
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
- 批准号:81973577
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
- 批准号:81602908
- 批准年份:2016
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
- 批准号:81501928
- 批准年份:2015
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
相似海外基金
The Phenomenon of Stem Cell Aging according to Methylation Estimates of Age After Hematopoietic Stem Cell Transplantation
根据造血干细胞移植后甲基化年龄估算干细胞衰老现象
- 批准号:
23K07844 - 财政年份:2023
- 资助金额:
$ 15.33万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Analysis of Age-dependent Functional Changes in Skeletal Muscle CB1 Receptors by an in Vitro Model of Aging-related Muscle Atrophy
通过衰老相关性肌肉萎缩的体外模型分析骨骼肌 CB1 受体的年龄依赖性功能变化
- 批准号:
22KJ2960 - 财政年份:2023
- 资助金额:
$ 15.33万 - 项目类别:
Grant-in-Aid for JSPS Fellows
Joint U.S.-Japan Measures for Aging and Dementia Derived from the Prevention of Age-Related and Noise-induced Hearing Loss
美日针对预防与年龄相关和噪声引起的听力损失而导致的老龄化和痴呆症联合措施
- 批准号:
23KK0156 - 财政年份:2023
- 资助金额:
$ 15.33万 - 项目类别:
Fund for the Promotion of Joint International Research (International Collaborative Research)
The Effects of Muscle Fatigability on Gait Instability in Aging and Age-Related Falls Risk
肌肉疲劳对衰老步态不稳定性和年龄相关跌倒风险的影响
- 批准号:
10677409 - 财政年份:2023
- 资助金额:
$ 15.33万 - 项目类别:
Characterizing gut physiology by age, frailty, and sex: assessing the role of the aging gut in "inflamm-aging"
按年龄、虚弱和性别表征肠道生理学特征:评估衰老肠道在“炎症衰老”中的作用
- 批准号:
497927 - 财政年份:2023
- 资助金额:
$ 15.33万 - 项目类别:
Deciphering the role of osteopontin in the aging eye and age-related macular degeneration
破译骨桥蛋白在眼睛老化和年龄相关性黄斑变性中的作用
- 批准号:
10679287 - 财政年份:2023
- 资助金额:
$ 15.33万 - 项目类别:
Role of AGE/RAGEsignaling as a driver of pathological aging in the brain
AGE/RAGE信号传导作为大脑病理性衰老驱动因素的作用
- 批准号:
10836835 - 财政年份:2023
- 资助金额:
$ 15.33万 - 项目类别:
Elucidation of the protein kinase NLK-mediated aging mechanisms and treatment of age-related diseases
阐明蛋白激酶NLK介导的衰老机制及年龄相关疾病的治疗
- 批准号:
23K06378 - 财政年份:2023
- 资助金额:
$ 15.33万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Underlying mechanisms of age-related changes in ingestive behaviors: From the perspective of the aging brain and deterioration of the gustatory system.
与年龄相关的摄入行为变化的潜在机制:从大脑老化和味觉系统退化的角度来看。
- 批准号:
23K10845 - 财政年份:2023
- 资助金额:
$ 15.33万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Targeting Age-Activated Proinflammatory Chemokine Signaling by CCL2/11 to Enhance Skeletal Muscle Regeneration in Aging
通过 CCL2/11 靶向年龄激活的促炎趋化因子信号传导以增强衰老过程中的骨骼肌再生
- 批准号:
478877 - 财政年份:2023
- 资助金额:
$ 15.33万 - 项目类别:
Operating Grants