Better memory with literacy acquisition later in life: a randomized controlled trial

晚年读写能力提高记忆力:一项随机对照试验

基本信息

项目摘要

Abstract Dementia is epidemic with a projected cost of $1.2 trillion by 2050. Currently, 2/3 of people with dementia live in low and middle-income countries (LMIC). 30% of dementia cases are preventable by modifying risk factors such as low education. Formal education acquired early in life protects against dementia, but whether acquiring education later in life can decrease dementia risk is less clear. Our previous cross-sectional work conducted in Brazil/UFMG in partnership with the USA/UCSF suggests that even few years of education might improve brain resilience by strengthening the relationship between episodic memory and medial temporal lobe structures, including the hippocampus (HC) and its connections. Whether acquiring education in adulthood could also strengthen those relationships and increase hippocampal efficiency is unknown. We started a pilot one-arm longitudinal study to determine whether a late-life literacy improves episodic memory measured by hippocampal functional and structural connectivity. Despite the historical challenges of enrolling illiterate adults in research, we devised a successful strategy and met the target enrollment and acquired baseline structural and functional MRIs, demonstrating feasibility of our approach. This proposal will build on and expand the collaboration between UFMG and UCSF to implement a two-arm, randomized controlled trial investigating the role of adult education in improving episodic memory and enhancing hippocampal connectivity. This partnership represents a unique opportunity to test this hypothesis given the combined expertise and resources from both centers. If successful in showing a benefit of adult education into memory, brain structure and function, this proposal will be critical for developing strategies to improve brain resilience and subsequently decrease dementia risk using a low-cost intervention. Noteworthy, The proposal will also contribute to build sustainable research capacity in Brazil by transferring the knowledge on advanced longitudinal neuroimaging analysis to UFMG. The learned techniques will be applied in further studies about neurological conditions conducted not only in UFMG but other Brazilian institutions.
摘要

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Lea Tenenholz Grinberg其他文献

Hypertension may associate with cerebral small vessel disease and infarcts through the pathway of intracranial atherosclerosis
  • DOI:
    10.1016/j.neurobiolaging.2024.11.001
  • 发表时间:
    2025-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Marcelo Kenzo Naya Takahashi;Regina Silva Paradela;Lea Tenenholz Grinberg;Renata Elaine Paraizo Leite;Daniela Souza Farias-Itao;Vitor Ribeiro Paes;Maria Eduarda Braga;Michel Satya Naslavsky;Mayana Zatz;Wilson Jacob-Filho;Ricardo Nitrini;Carlos Augusto Pasqualucci;Claudia Kimie Suemoto
  • 通讯作者:
    Claudia Kimie Suemoto
Cause of Death Determined by Full-body Autopsy in Neuropathologically Diagnosed Dementias
通过全身尸检确定神经病理学诊断的痴呆症的死因
  • DOI:
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    2.1
  • 作者:
    Beatriz Astolfi Neves;Paula Villela Nunes;Roberta Diehl Rodriguez;Atmis Medeiros Haidar;Renata Elaine Paraizo Leite;C. Nascimento;Carlos Augusto Pasqualucci;R. Nitrini;W. Jacob;B. Lafer;Lea Tenenholz Grinberg;Claudia Kimie Suemoto
  • 通讯作者:
    Claudia Kimie Suemoto

Lea Tenenholz Grinberg的其他文献

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{{ truncateString('Lea Tenenholz Grinberg', 18)}}的其他基金

Imaging brain iron and protein aggregation with MRI for assessing Alzheimer's disease pathology and progression
使用 MRI 对脑铁和蛋白质聚集进行成像,以评估阿尔茨海默病的病理学和进展
  • 批准号:
    10563181
  • 财政年份:
    2021
  • 资助金额:
    $ 15.48万
  • 项目类别:
Imaging brain iron and protein aggregation with MRI for assessing Alzheimer's disease pathology and progression
使用 MRI 对脑铁和蛋白质聚集进行成像,以评估阿尔茨海默病的病理学和进展
  • 批准号:
    10331335
  • 财政年份:
    2021
  • 资助金额:
    $ 15.48万
  • 项目类别:
Core C: Human Tissue Validation
核心 C:人体组织验证
  • 批准号:
    10295515
  • 财政年份:
    2021
  • 资助金额:
    $ 15.48万
  • 项目类别:
Better memory with literacy acquisition later in life: a randomized controlled trial
晚年读写能力提高记忆力:一项随机对照试验
  • 批准号:
    10054007
  • 财政年份:
    2020
  • 资助金额:
    $ 15.48万
  • 项目类别:
Clinical Features and Neuropathological Basis of Sleep Wake Behavior in Alzheimer's and PSP
阿尔茨海默病和 PSP 睡眠觉醒行为的临床特征和神经病理学基础
  • 批准号:
    10112791
  • 财政年份:
    2019
  • 资助金额:
    $ 15.48万
  • 项目类别:
Linking Sleep Dysfunction to Tau-related Degeneration across AD Progression
将睡眠功能障碍与 AD 进展过程中 Tau 蛋白相关的退化联系起来
  • 批准号:
    10636812
  • 财政年份:
    2019
  • 资助金额:
    $ 15.48万
  • 项目类别:
Linking Sleep Dysfunction to Tau-related Degeneration across AD Progression
将睡眠功能障碍与 AD 进展过程中 Tau 蛋白相关的退化联系起来
  • 批准号:
    10441484
  • 财政年份:
    2019
  • 资助金额:
    $ 15.48万
  • 项目类别:
Linking Sleep Dysfunction to Tau-related Degeneration across AD Progression
将睡眠功能障碍与 AD 进展过程中 Tau 蛋白相关的退化联系起来
  • 批准号:
    10328419
  • 财政年份:
    2019
  • 资助金额:
    $ 15.48万
  • 项目类别:
Linking Sleep Dysfunction to Tau-related Degeneration across AD Progression
将睡眠功能障碍与 AD 进展过程中 Tau 蛋白相关的退化联系起来
  • 批准号:
    9803439
  • 财政年份:
    2019
  • 资助金额:
    $ 15.48万
  • 项目类别:
Clinical Features and Neuropathological Basis of Sleep Wake Behavior in Alzheimer's and PSP
阿尔茨海默病和 PSP 睡眠觉醒行为的临床特征和神经病理学基础
  • 批准号:
    10589765
  • 财政年份:
    2019
  • 资助金额:
    $ 15.48万
  • 项目类别:

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