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Core C: Human Tissue Validation

Core C: Human Tissue Validation
核心 C：人体组织验证
批准号：
10295515
负责人：
Lea Tenenholz Grinberg
金额：
$12.92万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
项目状态：
未结题
起止时间：
2021-09-01 至 2026-08-31
来源：
https://reporter.nih.gov/project-details/10295515
关键词：
17q21AfricanAreaAutopsyBiocompatible MaterialsBiologyBrainBrain DiseasesCaucasiansChromosomesClinicalComplexDataData AnalysesDatabasesDiseaseEventExperimental ModelsFemaleFlowchartsFosteringFreezingFundingGeneticGenomicsGoalsGrantHaplotypesHumanHuman BiologyLeadLeadershipLinkMapsMidbrain structureMiddle frontal gyrus structureModelingMutationNerve DegenerationNeurodegenerative DisordersNeurosciencesPathogenicityPathologyPatientsPositioning AttributeProgressive Supranuclear PalsyProteomicsPublicationsResearchResearch PersonnelResearch SupportRiskRoleSamplingShippingSpecimenStructure of inferior temporal gyrusStructure of superior frontal gyrusSystemTauopathiesTissue StainsTissuesTrainingValidationWorkautomated analysisbrain tissuedesignexperimental studyhuman tissuein vitro Assaymalemeetingsmultiplex assayneuropathologyprogramsputamenranpirnasespatial relationshiptau Proteinstau mutationtherapeutic targettooltranslational neuroscience

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PROJECT SUMMARY (CORE C: HUMAN TISSUE VALIDATION) The Human Tissue Validation Core will provide vital research support to the CWOW. Neurodegenerative disease pathology and genetics have become increasingly exciting and complex in recent years, with major advances arising from work accomplished using human postmortem tissue. In this application, Dr. Lea T. Grinberg will lead the Human Tissue Validation Core (Core C). The Human Core goals are to (1) directly supporting this CWOW’s Projects with well-characterized and carefully treated human tissue from tauopathy patients and controls; (2) validating the relevance results from Projects 1 and 2 in human specimens and assembloids; (3) developing enhanced tools for boosting the amount of information retrieved for each single biospecimen samples.
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