5-Cog Battery to improve detection of cognitive impairment and dementia

5-Cog 电池可改善认知障碍和痴呆症的检测

基本信息

  • 批准号:
    10263305
  • 负责人:
  • 金额:
    $ 82.17万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-09-25 至 2022-08-31
  • 项目状态:
    已结题

项目摘要

Cognitive impairment related to dementia is frequently under-diagnosed in primary care settings despite the availability of numerous assessment tools. Missed detection delays treatment of reversible conditions as well as provision of support services and critical planning. This problem is more prevalent among older African- Americans and Hispanics than among older whites. Our group has two decades of experience developing tools to detect dementia in health disparate populations. Notably, we developed the Picture-based Memory Impairment Screen (PMIS) that relies on culture fair pictures and does not need to be administered by a medical professional. We also validated the Motoric Cognitive Risk syndrome (MCR). This highly accessible test relies on the presence of slow gait and cognitive self-complaints to identify individuals at high risk of converting to dementia. Both the PMIS and the MCR are highly sensitive and specific first-line assays that can be followed up with more thorough and complex cognitive testing. Building on our work, we propose to develop and validate a 5-minute screen (5-Cog) to identify persons at high risk of developing dementia and to flag them for further evaluation. We propose to do this in urban, multi-ethnic Bronx primary care populations with socio-economic challenges. The 5-Cog battery will include the PMIS, MCR syndrome diagnosis, and a 2-item depression screener. In the 18-month UG3 phase, we propose to fine-tune the components of the 5-Cog that will be tested in a health disparate population in the Bronx, and could be extended to other participating sites under this RFA. We will also test the feasibility of administering the 5-Cog by non-physicians to increase accessibility of our battery in primary care settings. In the 42-month UH3 phase, we propose a single-blind, randomized clinical trial in 1,200 older primary care patients presenting with cognitive complaints who will be randomized to receive either the 5-Cog battery (intervention group) or a 5-minute health literacy questionnaire (control group). Non-physicians will administer the intervention and control tests in primary care sites, and test results will be provided to primary care physicians for further action. ‘Improved dementia care’ will be measured by using a composite endpoint including new Mild Cognitive Impairment syndrome (MCI) or dementia diagnoses, laboratory investigations to rule out reversible causes of cognitive impairment, new dementia medication prescriptions, and specialist or social work referrals. The outcome events will be tracked using our electronic health record system. We will also conduct health care utilization and cost effectiveness analysis of the 5-Cog intervention in real-world settings. By the end of the UH3 phase, we will create a web registry to make 5-Cog test items and procedures available for download by health care professionals. The 5-Cog battery will overcome many of the implementation barriers of previous cognitive screens; it will be fast, low cost, easy to implement (requires only pen, paper and stopwatch), can be administered by non- clinicians after minimal training, not educationally or culturally biased, not confounded by depression and does not require informants.
在初级保健机构中,与痴呆症相关的认知障碍往往未得到充分诊断

项目成果

期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Motoric Cognitive Risk Syndrome in Polypharmacy.
Cross-Cultural Comparisons of Subjective Cognitive Complaints in a Diverse Primary Care Population.
Is the Montreal cognitive assessment culturally valid in a diverse geriatric primary care setting? Lessons from the Bronx.
蒙特利尔认知评估在多元化的老年初级保健环境中在文化上有效吗?
  • DOI:
    10.1111/jgs.18705
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    6.3
  • 作者:
    Stimmel,MarninaB;Orkaby,ArielaR;Ayers,Emmeline;Verghese,Joe;Nsubayi,CelesteK;Weiss,EricaF
  • 通讯作者:
    Weiss,EricaF
Prodromal Motoric Cognitive Risk Syndrome and Everyday Function.
  • DOI:
    10.3233/jad-230579
  • 发表时间:
    2023-10
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Nigel L. Kravatz;Dristi Adhikari;E. Ayers;Joseph Verghese
  • 通讯作者:
    Nigel L. Kravatz;Dristi Adhikari;E. Ayers;Joseph Verghese
Everyday function profiles in prodromal stages of MCI: Prospective cohort study.
MCI 前驱阶段的日常功能概况:前瞻性队列研究。
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JOE VERGHESE其他文献

JOE VERGHESE的其他文献

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{{ truncateString('JOE VERGHESE', 18)}}的其他基金

The biological underpinnings of Motoric Cognitive Risk syndrome: a multi-center study
运动认知风险综合征的生物学基础:一项多中心研究
  • 批准号:
    10359867
  • 财政年份:
    2020
  • 资助金额:
    $ 82.17万
  • 项目类别:
The biological underpinnings of Motoric Cognitive Risk syndrome: a multi-center study
运动认知风险综合征的生物学基础:一项多中心研究
  • 批准号:
    10183121
  • 财政年份:
    2020
  • 资助金额:
    $ 82.17万
  • 项目类别:
The biological underpinnings of Motoric Cognitive Risk syndrome: a multi-center study
运动认知风险综合征的生物学基础:一项多中心研究
  • 批准号:
    10611122
  • 财政年份:
    2020
  • 资助金额:
    $ 82.17万
  • 项目类别:
The biological underpinnings of Motoric Cognitive Risk syndrome: a multi-center study
运动认知风险综合征的生物学基础:一项多中心研究
  • 批准号:
    10377509
  • 财政年份:
    2020
  • 资助金额:
    $ 82.17万
  • 项目类别:
The biological underpinnings of Motoric Cognitive Risk syndrome: a multi-center study
运动认知风险综合征的生物学基础:一项多中心研究
  • 批准号:
    10612349
  • 财政年份:
    2020
  • 资助金额:
    $ 82.17万
  • 项目类别:
The biological underpinnings of Motoric Cognitive Risk syndrome: a multi-center study
运动认知风险综合征的生物学基础:一项多中心研究
  • 批准号:
    9562162
  • 财政年份:
    2017
  • 资助金额:
    $ 82.17万
  • 项目类别:
5-Cog Battery to improve detection of cognitive impairment and dementia
5-Cog 电池可改善认知障碍和痴呆症的检测
  • 批准号:
    9769547
  • 财政年份:
    2017
  • 资助金额:
    $ 82.17万
  • 项目类别:
Cognitive sequelae of the biological effects of COVID-19 on the nervous system in a health disparity population
COVID-19 对健康差异人群神经系统的生物效应的认知后遗症
  • 批准号:
    10228116
  • 财政年份:
    2017
  • 资助金额:
    $ 82.17万
  • 项目类别:
Biological and neural mechanisms of falls
跌倒的生物学和神经机制
  • 批准号:
    9293219
  • 财政年份:
    2013
  • 资助金额:
    $ 82.17万
  • 项目类别:
Biological and neural mechanisms of falls
跌倒的生物学和神经机制
  • 批准号:
    8845349
  • 财政年份:
    2013
  • 资助金额:
    $ 82.17万
  • 项目类别:

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