CORE-- NEUROPATHOLOGY

神经病理学核心的目的是提供技术资源， 实验室设施和专业知识用于采集， 尸检获得的脑组织的诊断和保存 印第安纳州ADC临床核心的对照研究，AS 以及来自其他机构的转介案例。神经病理学 CORE将向家庭提供有关病理数据的信息， 推荐内科医生和基础研究人员。此外，核心将 参与社区有关新事物的持续教育 阿尔茨海默病(AD)研究的新进展。 我们对分子、生化、组织化学、 阿尔茨海默病的病理和临床方面在 过去的五年里。因此，痴呆症患者的脑组织必须 为诊断和研究目的而研究，使用多学科 接近。我们建立了痴呆症实验室，开发了一种 退行性脑疾病形态计量学研究实验室 扩充了我们的脑库。CORE对调查工作做出了贡献 遗传性老年前期痴呆伴神经原纤维缠绕(I) 家族性阿尔茨海默病APP基因突变的特征(II) Gerstmann-Straussler神经病理表型的特征 印第安纳州家系中的Sckeinker(GSS)病，(Iii)研究tau 神经退行性疾病的病理学，(Iv)扩大我们对 APP和PRNP基因突变引起疾病的神经病理学研究 基因，(V)发现新形式的老年前期痴呆。 我们正在扩大我们的使命，将现代分子技术整合到 协助诊断痴呆症，特别是大脑痴呆 淀粉样变性。事实上，我们正在结合神经形态学获得的数据， 免疫组织化学和免疫细胞化学来识别和 表征分子的定位和抗原性 在成人痴呆症的发病机制中起重要作用。这 分析是探索表型异质性的基础。 此外，通过使用尸检中获得的脑组织以及从 石蜡包埋材料，我们将定义分子遗传学 个别案例。具体地说，我们将使用允许我们 识别目前已知的导致阿尔茨海默病的基因中描述的突变 其他痴呆症。我们认为这种多学科的方法 ADC神经病理核心需要在 组织学、生化和DNA水平，充分利用 收集的材料。

The aims of the Neuropathology Core are to provide technical resources, laboratory facilities and professional expertise for the collection, diagnosis and storage of brain tissue obtained at autopsy from patients and control subjects studies in the Clinical Core of the Indiana ADC, as well as from referral cases from other institutions. The Neuropathology Core will provide information about pathologic data to families, referring physicians and basic researchers. In addition, the Core will be involved in continuing education to the community about new developments emerging from Alzheimer disease (AD) research. Our understanding of the molecular, biochemical, histochemical, pathologic and clinical aspects of AD has advanced rapidly during the last five years. Thus, brain tissue of demented individuals must be studied for diagnostic and research purposes using a multidisciplinary approach. We have established a Dementia Laboratory, developed a laboratory for morphometric studies of degenerative brain diseases and expanded our Brain Bank. The Core has contributed to the investigations of hereditary presenile dementias with neurofibrillary tangles by (i) characterizing familial AD with a mutation in APP gene, (ii) characterizing the neuropathologic phenotype of Gerstmann-Straussler- Sckeinker (GSS) disease in the Indiana kindred, (iii) studying tau pathology in neurodegenerative disease, (iv) expanding our knowledge on the Neuropathology of diseases caused by mutations in the APP and PRNP genes, (v) discovering new forms of presenile dementias. We are expanding our mission integrating modern molecular technology to assist in the diagnosis of dementias, in particular the cerebral amyloidoses. In fact, we are combining data obtained by neuromorphology, immunohistochemistry, and immunocytochemistry to recognize and characterize the localization and the antigenic profile of molecules that are important to the pathogenesis of dementia of the adult. This analysis is fundamental to explore phenotypic heterogeneity. Furthermore, by using brain tissue obtained at autopsy as well as from paraffin embedded material, we will define the molecular genetics of individual cases. Specifically, we will use technology that allows us to recognize mutations described in genes currently known to cause AD and other dementias. We consider that this multidisciplinary approach required for an ADC Neuropathology Core to provide diagnosis at the histological, biochemical and DNA level, taking full advantage of the collected material.