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Core 1: Biospecimen/Pathology

核心 1：生物样本/病理学

基本信息

批准号：
10263345
负责人：
Shannon Jones McCall
金额：
$ 10.02万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-14 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10263345
关键词：
Accreditation African American American Award Bioinformatics Biological Biomedical Research Biopsy Blood Blood specimen Cancer Center Support Grant Cancer Model Catchment Area Cell Culture Techniques Clinical Clinical Research Collection Colon Carcinoma Communities Community Outreach Consent Cooperative Human Tissue Network Country Data Data Analyses Development Ensure Equipment and supply inventories Ethnic Origin Exposure to Fresh Tissue Funding Future Generations Goals Helicobacter pylori Histology Immunohistochemistry Informed Consent Institutes International KRASG12D Libraries Link Liquid substance Malignant Neoplasms Malignant neoplasm of lung Minority Groups Minority Participation Modeling Molecular Mutate Neoadjuvant Therapy Neoplasm Metastasis Nucleic Acids Participant Pathologist Pathology Patients Pilot Projects Primary Neoplasm Process Protocols documentation Race Research Research Design Research Institute Research Personnel Research Project Grants Resource Sharing Retrospective cohort Sampling Services Societies Specimen Stomach Therapeutic Intervention Tissue Procurements Tissue Sample Tissues Translational Research Trust Underrepresented Minority Underrepresented Populations Update base biobank black patient cancer health disparity career development cohort college community engagement data registry health equity human model improved innovation meetings metabolomics molecular phenotype patient derived xenograft model programs repository sample collection success transcriptome sequencing translational cancer research tumor registry

项目摘要

ABSTRACT – Biospecimen/Pathology Core (Core 1) The Biospecimen/Pathology Core of the Duke Cancer Health Disparities P20 SPORE (DCHD) leverages and is housed in the Duke Cancer Institute’s BioRepository & Precision Pathology Center (BRPC). The BRPC is a Shared Resource of the Duke Cancer Institute and supported in part by the Duke Cancer Center Support Grant (5P30-CA014236-45). This NCI-funded shared service center obtains broad consent from patients for blood and tissue sample donation and procures, processes and banks both liquid and tissue biospecimens, supports Duke’s “living biobank” with the Duke Patient-Derived Xenograft and Primary Tumor Cell Culture Services, and implements bioinformatic and clinical strategies for precise sample and model annotation. For the DCHD, the Core will efficiently provide high-quality tissue, blood and fluid-based biospecimens and processing services to requesting investigators, and continue to adjust practices as researcher needs evolve (Aim 1); support current and future DCHD P20 projects through expansion of existing best practices in tissue procurement, processing, and sample management (Aim 2); and educate the local, regional and national community on the importance of available biospecimens in biomedical research to enhance availability of specimens and data from underrepresented minorities (Aim 3). The Duke BRPC has recently been awarded an NCI UM1 to join the Cooperative Human Tissue Network (CHTN)(www.chtn.org); this network of biorepositories will support deeper cohort generation from across the country. For the proposed Projects, we will provide appropriate lung cancer specimens and associated data from multiple races/ethnicities (Project 1), and stomach biopsies positive for H. pylori from Black patients (Project 2). The needs of future Pilot Projects will be assessed for feasibility; given the BRPC’s existing library, a recent focus on underrepresented minority inclusion, and CHTN participation, a wide range of cancer disparities research should be possible. This Core is fully integrated into the DCHD and is critical for its success.

摘要：生物标本/病理学核心（核心1）