Core 1: Biospecimen/Pathology
核心 1:生物样本/病理学
基本信息
- 批准号:10037510
- 负责人:
- 金额:$ 9.82万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-14 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:AccreditationAfrican AmericanAmericanAwardBioinformaticsBiologicalBiomedical ResearchBiopsyBloodBlood specimenCancer Center Support GrantCancer ModelCatchment AreaCell Culture TechniquesClinicalClinical ResearchCollectionColon CarcinomaCommunitiesCommunity OutreachConsentCooperative Human Tissue NetworkCountryDataData AnalysesDevelopmentEnsureEquipment and supply inventoriesEthnic OriginExposure toFresh TissueFundingFutureGenerationsGoalsHelicobacter pyloriHistologyImmunohistochemistryInformed ConsentInstitutesInternationalLibrariesLinkLiquid substanceMalignant NeoplasmsMalignant neoplasm of lungMinority GroupsMinority ParticipationModelingMolecularMutateNeoadjuvant TherapyNeoplasm MetastasisNucleic AcidsParticipantPathologistPathologyPatientsPilot ProjectsPrimary NeoplasmProcessProtocols documentationRaceResearchResearch DesignResearch InstituteResearch PersonnelResearch Project GrantsResource SharingRetrospective cohortSamplingServicesSocietiesSpecimenStomachTherapeutic InterventionTissue ProcurementsTissue SampleTissuesTranslational ResearchTrustUnderrepresented MinorityUnderrepresented PopulationsUpdateXenograft procedurebasebiobankcancer health disparitycareer developmentcohortcollegedata registryhealth equityhuman modelimprovedinnovationmeetingsmetabolomicsmolecular phenotypeprogramsrepositorysample collectionsuccesstranscriptome sequencingtranslational cancer researchtumor registry
项目摘要
ABSTRACT – Biospecimen/Pathology Core (Core 1)
The Biospecimen/Pathology Core of the Duke Cancer Health Disparities P20 SPORE (DCHD) leverages and is
housed in the Duke Cancer Institute’s BioRepository & Precision Pathology Center (BRPC). The BRPC is a
Shared Resource of the Duke Cancer Institute and supported in part by the Duke Cancer Center Support Grant
(5P30-CA014236-45). This NCI-funded shared service center obtains broad consent from patients for blood and
tissue sample donation and procures, processes and banks both liquid and tissue biospecimens, supports
Duke’s “living biobank” with the Duke Patient-Derived Xenograft and Primary Tumor Cell Culture Services, and
implements bioinformatic and clinical strategies for precise sample and model annotation. For the DCHD, the
Core will efficiently provide high-quality tissue, blood and fluid-based biospecimens and processing services to
requesting investigators, and continue to adjust practices as researcher needs evolve (Aim 1); support current
and future DCHD P20 projects through expansion of existing best practices in tissue procurement, processing,
and sample management (Aim 2); and educate the local, regional and national community on the importance of
available biospecimens in biomedical research to enhance availability of specimens and data from
underrepresented minorities (Aim 3). The Duke BRPC has recently been awarded an NCI UM1 to join the
Cooperative Human Tissue Network (CHTN)(www.chtn.org); this network of biorepositories will support
deeper cohort generation from across the country. For the proposed Projects, we will provide appropriate
lung cancer specimens and associated data from multiple races/ethnicities (Project 1), and stomach biopsies
positive for H. pylori from Black patients (Project 2). The needs of future Pilot Projects will be assessed for
feasibility; given the BRPC’s existing library, a recent focus on underrepresented minority inclusion, and CHTN
participation, a wide range of cancer disparities research should be possible. This Core is fully integrated into
the DCHD and is critical for its success.
摘要 - 生物测量/病理核心(核心1)
杜克癌症健康差异P20孢子(DCHD)的生物测量/病理核心
位于杜克癌症研究所的生物术与精密病理学中心(BRPC)中。 BRPC是一个
杜克癌症研究所的共享资源,并得到了杜克癌症中心支持赠款的部分支持
(5P30-CA014236-45)。该NCI资助的共享服务中心获得了患者血液和
组织样品捐赠和采购,过程和液体和组织生物测量,支持
杜克大学的“活生物库”,带有杜克患者衍生的异种移植物和原发性肿瘤细胞培养服务,以及
实现精确样本和模型注释的生物信息学和临床策略。对于DCHD,
核心将有效地提供高质量的组织,血液和基于流体的生物测量以及处理服务
要求调查人员,并继续调整实践,因为研究人员需要进化(AIM 1);支持电流
以及未来的DCHD P20项目通过扩展组织采购,加工,
和样本管理(AIM 2);并教育地方,地区和民族社区的重要性
生物医学研究中可用的生物测量,以提高标本和数据的可用性
代表性不足的少数民族(AIM 3)。 Duke BRPC最近被授予NCI UM1加入
合作人组织网络(CHTN)(www.chtn.org);这个生物库网络将支持
来自全国各地的更深层。对于拟议的项目,我们将提供适当的
肺癌标本和来自多个种族/族裔的相关数据(项目1)和stallch活检
黑人患者的幽门螺杆菌阳性(项目2)。未来的试点项目的需求将被评估
可行性;考虑到BRPC的现有图书馆,最近关注代表性不足的少数群体包容性和CHTN
参与,应该进行广泛的癌症差异研究。该核心已完全集成到
DCHD对于成功至关重要。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Shannon Jones McCall其他文献
Shannon Jones McCall的其他文献
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{{ truncateString('Shannon Jones McCall', 18)}}的其他基金
Cooperative Human Tissue Network Support through Duke's BioRepository & Precision Pathology Center
通过杜克大学生物资源库提供合作人体组织网络支持
- 批准号:
10612337 - 财政年份:2019
- 资助金额:
$ 9.82万 - 项目类别:
Cooperative Human Tissue Network Support through Duke's BioRepository & Precision Pathology Center
通过杜克大学生物资源库提供合作人体组织网络支持
- 批准号:
9925215 - 财政年份:2019
- 资助金额:
$ 9.82万 - 项目类别:
Cooperative Human Tissue Network Support through Duke's BioRepository & Precision Pathology Center
通过杜克大学生物资源库提供合作人体组织网络支持
- 批准号:
10362736 - 财政年份:2019
- 资助金额:
$ 9.82万 - 项目类别:
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