Cooperative Human Tissue Network Support through Duke's BioRepository & Precision Pathology Center

通过杜克大学生物资源库提供合作人体组织网络支持

• 批准号: 10612337
• 负责人: Shannon Jones McCall
• 金额: $ 65.38万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-02 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10612337
• 关键词: Accreditation; Address; Adult; African American; American; Audience Research; Benign; Biological Assay; Biological Preservation; Biomedical Research; Blood; Blood specimen; California; Cancer Model; Cancer Patient; Caring; Chicago; Clinical; Clinical Sciences; Colon Carcinoma; Communication; Communities; Community Health Education; Community Outreach; Consent; Consultations; Cooperative Human Tissue Network; Cytopathology; Dedications; Diagnosis; Disease; E-learning; Education; Ensure; Equipment; Feedback; Genotype; Goals; Hematopathology; Hospitals; Human; Human Resources; Image Analysis; Immunohistochemistry; In Situ Hybridization; Infrastructure; Institution; International; Interview; Journalism; KRASG12D; Knowledge; Laboratories; Lasers; Lead; Leadership; Link; Liquid substance; Location; Los Angeles; Malignant - descriptor; Malignant Neoplasms; Medical; Medical Research; Metastatic Neoplasm to the Bone; Methods; Michigan; Microdissection; Minority Groups; Mission; Mutate; National Cancer Institute; Neoadjuvant Therapy; Neoplasm Metastasis; Newsletter; North Carolina; Nucleic Acids; Outcome; Pamphlets; Pathologist; Pathology; Patients; Persons; Phenotype; Population; Printing; Publications; Publishing; Recommendation; Research; Research Personnel; Role; Sampling; Scientist; Services; Specimen; Technology; Testing; Tissue Microarray; Tissue Sample; Tissues; Translational Research; Trust; Underrepresented Minority; Universities; Washington; Writing; anticancer research; biobank; calcification; college; community engagement; design; digital imaging; experience; flexibility; human model; improved; meetings; member; metabolomics; new technology; news; phenotypic biomarker; podcast; posters; preservation; programs; public health relevance; quantitative imaging; research study; sample collection; social media; support network; transcriptome sequencing; translational cancer research; trend; tumor; verbal; web page; whole slide imaging

PROJECT ABSTRACT High-quality biospecimens are critical to cancer research. This project leverages the CAP-accredited biorepository infrastructure, human resources, experience and equipment of the Duke BioRepository & Precision Pathology Center (BRPC) director, team members and its' affiliated networked core laboratories to provide high-quality biospecimens to investigators through the National Cancer Institute's Cooperative Human Tissue Network (CHTN). This and the additional CHTN missions of biobanking best practice dissemination and community education are addressed through the following four specific aims. Aim 1: Efficiently provide high-quality tissue, blood and fluid biospecimens to CHTN investigators for basic and early translational research. Specimen collection is facilitated through BRPC and its network of best practice biorepositories including those at the University of California at Los Angeles, the University of Michigan, Washington University at St. Louis, University of North Carolina at Chapel Hill, and the University of Chicago. The use of broad consent at Duke and in network locations provides maximum flexibility in long-term clinical annotation. The latest technologies in sample processing including viable specimen preservation, tumor enrichment by macro or microdissection, nucleic acid extraction, genotyping, biomarker phenotyping, whole slide imaging, tissue microarray, immunohistochemistry and in situ hybridization, and digital image analysis are also available. Aim 2: Provide consultation. Duke pathologists and biorepository staff provide expert consultation to CHTN investigators on use of human biospecimens, assay selection and sample processing with an eye toward fit-for-purpose pre-analytics. Aim 3: Develop and disseminate knowledge on high-quality practices for biorepositories. This CHTN team will take on new projects and disseminate results through publication and presentation at national and international meetings. The PI will continue to serve in national and international leadership roles within the biorepository community. Aim 4: Educate the local, regional and national community on the importance of biospecimens in biomedical research. Locally, the Duke team will expand community `biobank tours' to educate the Durham, NC population on the importance of including tissue and blood samples in research and specifically increasing the number of samples available from underrepresented minorities. Nationally, the PI will continue to seek opportunities to educate the public and the scientific community about the importance of having sufficient, high-quality, annotated biospecimens available for research. Examples include national podcasts and meeting presentations geared toward general scientific research audiences and taking advantage of print, audio and video journalism geared toward the lay public such as newsletters, social media postings and interviews.

项目摘要 高质量的生物样本对于癌症研究至关重要。该项目利用了 CAP 认可的 杜克大学生物样本库的生物样本库基础设施、人力资源、经验和设备 精准病理中心（BRPC）主任、团队成员及其附属网络核心 实验室通过国家癌症研究所向研究人员提供高质量的生物样本 人体组织合作网络（CHTN）。这项任务以及生物样本库的其他 CHTN 任务是最好的 通过以下四个具体目标来解决实践传播和社区教育问题。 目标 1：高效地为 CHTN 研究人员提供高质量的组织、血液和体液生物样本 基础和早期转化研究。通过 BRPC 及其网络促进样本采集 最佳实践生物样本库，包括加州大学洛杉矶分校的生物样本库 密歇根大学、华盛顿大学圣路易斯分校、北卡罗来纳大学教堂山分校、 和芝加哥大学。在杜克大学和网络位置使用广泛的同意可以提供 长期临床注释的最大灵活性。样品处理的最新技术 包括活样本保存、通过宏观或显微切割富集肿瘤、核酸 提取、基因分型、生物标志物表型、全玻片成像、组织微阵列、 还可以进行免疫组织化学、原位杂交以及数字图像分析。目标 2： 提供咨询。杜克大学病理学家和生物样本库工作人员为CHTN提供专家咨询 研究人员使用人类生物样本、分析选择和样品处理，着眼于 适合目的的预分析。目标 3：开发和传播关于高质量实践的知识 生物储存库。 CHTN 团队将承担新项目并通过出版物传播成果 以及在国内和国际会议上的演讲。 PI将继续在国家和 生物样本库界的国际领导角色。目标 4：教育当地、区域和 国家社会关于生物样本在生物医学研究中的重要性。在当地，杜克大学队 将扩大社区“生物库之旅”，以教育北卡罗来纳州达勒姆市的人们了解生物库的重要性 在研究中包括组织和血液样本，并特别增加样本数量 来自代表性不足的少数群体。在全国范围内，PI 将继续寻求机会 教育公众和科学界了解拥有充足、高质量、 带注释的生物样本可用于研究。示例包括国家播客和会议 面向一般科学研究受众并利用印刷品、音频的演示 面向普通公众的视频新闻，例如时事通讯、社交媒体帖子和 采访。