BLRD Research Career Scientist Award Application

老龄化是许多慢性疾病的最大风险因素，包括癌症、神经退行性变、糖尿病、 和心脏病。目前，大约一半的退伍军人管理局人口年龄在65岁以上，在接下来的十年里， 预计这些退伍军人中将有300多万人超过75岁。因此，研究调节衰老的基因 而与衰老相关的病理对生物医学的进步至关重要，以造福退伍军人 健康。这项研究项目研究了两个这样的基因，SIRT6和SIRT7，它们是主基因 衰老组织中许多变化的“调节器”，如DNA损伤、代谢和氧化应激， 细胞衰老和炎症。我们的项目研究了这些基因的活性如何降低 在心血管和肝脏疾病、糖尿病、肥胖症和许多癌症中的病理作用，以及如何 激活这些基因可以预防这些疾病。通过确定可以作为目标的路径 对于治疗，这项研究可以直接影响退伍军人的健康。 。

Aging is the greatest risk factor for many chronic diseases including cancer, neurodegeneration, diabetes, and heart disease. Currently, roughly half of the VA population is aged 65+ years, and in the next ten years, more than 3 million of these veterans are expected to be over 75. Thus, studying genes that regulate aging and aging-associated pathologies is critically important for biomedical advancements to benefit veterans’ health. This research program investigates two such genes, SIRT6 and SIRT7, which are “master regulators” of many changes in aging tissues, such as DNA damage, metabolic and oxidative stress, cellular senescence, and inflammation. Our projects study how decreased activity of these genes may contribute to pathologies in cardiovascular and liver disease, diabetes, obesity, and many cancers, and how activating these genes could protect against these pathologies. By identifying pathways that can be targeted for therapy, this research can directly impact the health of the Veteran population. .