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Harvard PRECISION Human Pain Center

哈佛精密人类疼痛中心

基本信息

批准号：
10594334
负责人：
William Russell Renthal
金额：
$ 264.74万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-19 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10594334
关键词：
Affect American Animal Model Atlases Autopsy Biological Assay Brain Cells Chronic Communities Data Data Set Data Store Ensure Erythromelalgia Explosion Feedback Future Gene Expression Profile Genes Genetic Genetic Variation Genomics Helping to End Addiction Long-term Human Human Genetics Individual Informed Consent Investigation Knowledge Logistics Medicine Methods Mission Molecular Monitor Mus Neuroglia Neuroimmune Neuroma Neurons Nociception Nociceptors Opioid Pain Pain Clinics Pain management Pain-Free Patients Peripheral Peripheral Nerves Phantom Limb Pain Phenotype Physics Physiological Physiology Population Population Heterogeneity Positioning Attribute Process Productivity Protocols documentation Publications Quality of life Research Research Personnel Sample Size Sampling Sensory Ganglia Technology Therapeutic Tissue Procurements Tissue Sample Tissues Translations Work cell type central sensitization chronic pain chronic pain patient chronic painful condition clinical translation cost effective data harmonization data sharing design effective therapy experience human tissue improved innovation insight meetings multiple omics novel opioid use disorder pain model pain signal single cell technology skills therapeutic target tissue processing tool transcriptomics tumor-immune system interactions

项目摘要

PROJECT SUMMARY (Overall) Chronic pain affects >25 million Americans per year, with enormous impacts on both quality of life and productivity. Despite advances in our understanding of nociception in animal models, new and effective treatments for patients with chronic pain have been lacking. The poor translation between mouse and human pain targets has highlighted limitations of animal models of pain. Recent advances in single-cell genomics and physiology directly in human tissue position pain researchers to make important new advances with improved opportunities for clinical translation. The Harvard PRECISION Human Pain Center proposes to leverage state- of-the-art single-cell technologies to characterize human nociceptor subtypes and how their gene expression patterns vary across diverse populations (Project 1) as well as in chronic pain conditions that clearly localize to these cells – chronic phantom limb pain associated with painful neuromas (Project 2). The Projects will generate a wealth of data for the scientific community by closely integrating with 5 Cores tasked with 1) procuring high- quality human pain-related tissues following strict regulatory practices, 2) offering the latest single-cell gene multi-omic technologies, 3) performing advanced single-cell spatial transcriptomic analysis, 4) managing, integrating, and distributing all of the data, and 5) administrating and connecting to Center the other PRECISION Human Pain Network Centers. The data generated by our Center will contribute to this broader PRECISION Human Pain Network and to help identify and prioritizate of novel pain therapeutic targets for future investigation.

项目总结（总体）