Long-term Opioid Therapy, Depression and Suicide Mortality Risk in Patients with Head and Neck Cancer

头颈癌患者的长期阿片类药物治疗、抑郁和自杀死亡风险

• 批准号: 10597344
• 负责人: Nosayaba Osazuwa-Peters
• 金额: $ 44.8万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2024-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10597344
• 关键词: Acute Pain; Adult; Anxiety; Benchmarking; Cancer Burden; Cancer Pain Management; Cancer Survivor; Caring; Clinical; Complex; Data; Depression and Suicide; Depression screen; Development; Dose; Dose-Rate; Frequencies; Fright; Future; Goals; Head and Neck Cancer; Helping to End Addiction Long-term; Human; Intervention; Investigation; Lead; Link; Literature; Long-Term Effects; Malignant Neoplasms; Medical Records; Medicare; Mental Depression; Morphine; Oncology; Opioid; Pain; Pain management; Patients; Persons; Population; Race; Recording of previous events; Research; Risk; Risk Factors; Role; Severities; Substance Use Disorder; Symptoms; Testing; United States Department of Veterans Affairs; United States National Institutes of Health; active method; advanced analytics; base; biological sex; cancer care; cancer pain; cancer site; cancer therapy; chronic pain; chronic pain management; clinical care; cohort; depressive symptoms; head and neck cancer patient; milligram; misuse of prescription only drugs; mortality risk; non-cancer pain; novel; opioid epidemic; opioid mortality; opioid therapy; opioid use; patient population; prescription opioid; prescription opioid misuse; psychosocial; public health relevance; response; secondary analysis; standard care; suicidal risk; suicide mortality; suicide rate

PROJECT SUMMARY/ABSTRACT The proposed project is in response to RFA-DE-22-011: HEAL Initiative: Secondary Analysis and Integration of Existing Data Related to Acute and Chronic Pain Development or Management in Humans. The HEAL Initiative is a trans-NIH project, Helping to End Addiction Long-term, was launched in 2018 as a direct response to the opioid crisis in the US. This crisis is even more complex in oncology as pain is one of the most feared symptom among cancer survivors, and opioid use is central to pain management in cancer care. While cancer survivors have a significantly increased risk of long-term use of opioid, in head and neck cancer (HNC), over 80% of patients have a history of receipt of opioid prescription during care, and up to 15% of patients continue using opioids long after active treatment, increasing their risk of long-term opioid therapy (LTOT), which is >90 days of opioid use following treatment. The need to characterize opioid use in HNC is underscored by the fact that HNC which only accounts for 3% of the total US cancer burden, might be responsible for 12% of opioid-related deaths among patients with cancer. Risk of both depression and suicide are higher among patients with HNC compared with the general US population; however, the relative contribution of long-term opioid treatment to these adverse psychosocial consequences of HNC is unknown. About 1-in-2 patients with HNC have a lifetime history of depression, which is significantly associated with chronic pain. In addition, HNC has the second highest rate of suicide of all cancer sites, also associated with chronic pain. It is unknown if LTOT is associated with risk of depression in these patients, or whether it increases risk of suicide in HNC. It is therefore critical to understand to establish the relative contribution of LTOT to adverse psychiatric sequelae in patients with HNC. Long-term, we hope to decrease depression and suicide risks in cancer, and develop and implement tailored interventions that will inform safe opioid prescribing, and provide evidence leading to alternative pain management in HNC and oncology care in general. Our long-term goals align with both the HEAL initiative, and several Healthy People 2030 objectives, such as reducing the proportion of adults who misuse prescription opioids, as well as decreasing suicide rate in the US by 25% in the next decade. However, to achieve these long-term goals, it is necessary to first quantify the role of LTOT in depression and suicide risks among patients with HNC beyond establishing correlations or associations. Using two distinct, independent large cohorts of patients with HNC, the objective of this proposed project is to establish the role of LTOT in depression and suicide among patients with HNC, using advanced analytics that allows for establishing temporality, dose-response and other causal-related inferences in observational data. Findings from this proposed research will impact clinical care in oncology related to safer opioid prescribing, and alternative pain management, which would decrease risk of depression and suicide in the HNC patient population.

项目总结/文摘