Specific Pathogen Free Baboon Research Resource (SPFBRR) - Bridge Funding Administrative Supplement

项目摘要 此申请是为“无特定病原体狒狒研究”申请桥梁资金的请求 资源”（SPFBRR）P40 OD 024628。SPFBRR是在美国国立卫生研究院的支持下成立的， 俄克拉荷马州健康科学中心（OUHSC）于2002年搬迁到基林中心，并于2017年搬迁到基林中心。的 SPFBRR自成立以来一直得到NIH的支持。SPFBRR是唯一一个 美国国立卫生研究院受资助者可获得的无外来病毒橄榄狒狒（Papio anubis）的研究资源; 包括FDA、NSF和NIH在内的联邦机构的内部研究计划;以及 生物医学研究（私人基金会、制药公司和合同研究组织）。 在整个世界上绝对独一无二，狒狒在SPFBRR有一个广泛的生物排斥名单，18 病原体通常在其他野生和圈养的非人类灵长类动物群落中发现。SPFBRR已经 将多个学科整合到一个旨在满足利用其研究人员需求的计划中。 资源在拟议的支助期间，妇发基金将继续增加资源， 提供给用户，并将继续增加新的信息，生物学和研究价值的病毒免费 狒狒到它的网站。狒狒仍然是基因工程猪的重要动物模型 异种移植，是呼吸道合胞病毒和百日咳的唯一NHP模型， 仍然是细菌性脓毒症的一个非常重要的模型。此外，狒狒是人类的优秀模型， 他们在开发批准的疫苗方面发挥了重要作用， SARS CoV-2.在接下来的一年里，SPFBRR将专注于维护SPF 18狒狒繁殖群 以满足当前和未来的生物医学研究需求。SPFBRR的总体目标是提供一个 国家无病毒橄榄狒狒研究资源;提供狒狒衍生生物材料; 为科学家、种群管理者和动物看护者提供教育和培训机会 并为研究人员提供设施和专业知识， 使用无病毒狒狒进行的研究。

PROJECT SUMMARY This application is a request for bridge funding for the “Specific Pathogen Free Baboon Research Resource” (SPFBRR) P40 OD024628. The SPFBRR was founded with NIH support at the University of Oklahoma Health Sciences Center (OUHSC) in 2002 and was relocated to the Keeling Center in 2017. The SPFBRR has received continuous NIH support since it was founded. The SPFBRR is the only national research resource of adventitious virus free olive baboons (Papio anubis) that are available to NIH grantees; intramural research programs of federal agencies, including the FDA, NSF and NIH; and other sponsors of biomedical research (private foundations, pharmaceutical companies, and contract research organizations). Absolutely unique in the entire world, the baboons in the SPFBRR have an extensive bioexclusion list of 18 pathogens normally found in other wild and captive nonhuman primate colonies. The SPFBRR has integrated multiple disciplines into a program designed to meet the needs of investigators who utilize its resources. During the proposed period of support, the SPFBRR will continue to improve the resources it provides to users and will continue to add new information about the biology and research value of virus free baboons to its website. Baboons continue to be important animal model for genetically engineered pig xenotransplantation, are the only NHP model of respiratory syncytial virus and whooping cough, and they remain a very important model of bacterial sepsis. Additionally, baboons are excellent models of human COVID associated pneumonia, and they were instrumental in the development of approved vaccines for SARS CoV-2. Over the next year the SPFBRR will focus on maintaining the SPF18 baboon breeding colony to meet current and future biomedical research needs. The overall goal of the SPFBRR is to provide a national research resource of virus free olive baboons; provide baboon derived biological materials; provide education and training opportunities to scientist, colony managers, and animal caregivers who want to work with baboons; and to provide investigators with facilities and expertise to conduct studies using virus free baboons.