NINDS Network for Excellence in Neuroscience: Clinical Research Site at UC Davis

NINDS 神经科学卓越网络：加州大学戴维斯分校的临床研究中心

• 批准号: 10593639
• 负责人: Craig M. McDonald
• 金额: $ 27.76万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10593639
• 关键词: Address; Adult; Affect; Biological Markers; California; Capital; Characteristics; Childhood; Cities; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Clinical Trials Cooperative Group; Clinical Trials Network; Communities; Community Outreach; Country; Data; Data Coordinating Center; Development; Disease; Doctor of Philosophy; Environment; Foundations; Functional disorder; Future; Goals; Health; Health system; Industry; Informatics; Infrastructure; Institutional Review Boards; Link; Metadata; Mission; Multi-Institutional Clinical Trial; National Institute of Neurological Disorders and Stroke; Natural History; Neurosciences; Neurosciences Research; Outcome; Patient Recruitments; Patients; Personal Satisfaction; Persons; Phase II Clinical Trials; Population; Positioning Attribute; Preparation; Protocols documentation; Public Health; Quality of life; Registries; Research; Research Infrastructure; Research Personnel; Research Training; Resource Informatics; Resources; Site; Specialist; Standardization; System; Testing; Translational Research; United States National Institutes of Health; Universities; Vision; Work; burden of illness; career; catalyst; clinical outcome measures; clinical research site; community engagement; design; drug development; drug discovery; experience; improved; improved functioning; innovation; nervous system disorder; new therapeutic target; novel therapeutics; outreach; phase 2 study; public-private partnership; response; skills; sound; success; supportive environment; telehealth; therapeutic development; translational pipeline; translational research program

NINDS Network for Excellence in Neuroscience: Clinical Research Site at UC Davis (PI: Craig M. McDonald, MD; Sub‐PI: Michael Rogawski, MD, PhD) This proposal contributes to the NINDS Network for Excellence in Neuroscience (NeuroNEXT) by renewing a clinical research site at the University of California Davis Health System located in Sacramento, CA, the capital of the most populous state in the country and one of the most diverse and integrated cities in the U.S. The UC Davis NeuroNEXT clinical research site will continue to contribute to the mission of NINDS by reducing the burden of neurologic diseases, and contribute an infrastructure which expands the NINDS capability to test promising new therapies, increase the efficiency of clinical trials, and respond quickly as new opportunities arise to test promising treatments for people with neurological disorders. Our experience as an existing NeuroNEXT site, neuroscience research excellence at UC Davis ‐ the most comprehensive campus in the University of California system, a robust translational research infrastructure housed in a nationally recognized, experienced, and competitively renewed NIH CTSA (the UC Davis CTSC), neuroscience research excellence, an innovative collaborative drug development pipeline from the University of California UC BRAID Drug Discovery Consortium, a national center of excellence in telehealth strategically positioned to promote community outreach, an innovative informatics such as the Tethered Metadata Registry for case identification, and access to diverse patients with neurological disorders managed in a highly ranked regional health system with active clinical affiliations, all work synergistically to position UC Davis to continue to be an outstanding Clinical Research Site for the NeuroNEXT network. UC Davis NeuroNEXT aims to: 1) Leverage existing resources and expertise to serve as a NeuroNEXT hub for implementing multicenter neuroscience clinical trials, increasing the efficiency and quality of trials conducted at the UC Davis site; 2) Collaborate with the University of California UC BRAID Drug Discovery Consortium to serve as a core resource for NeuroNEXT and function as a catalyst for innovative therapeutic development across the translational spectrum; 3) Provide local and regional community outreach to improve patient recruitment and retention and fully integrate community partners into the translational research enterprise; 4) Efficiently utilize, diversify, and leverage innovative telehealth and informatics resources for clinical trials; and 5) Provide collaborative and innovative clinical research training and a supportive environment for diverse early‐career investigators to develop additional research skills and become independent clinical investigators. Our accomplishments to date – locally, regionally, and nationally – provide an outstanding foundation for future success.

NINDS 神经科学卓越网络：加州大学戴维斯分校临床研究中心（PI：Craig M. McDonald，医学博士；副 PI：Michael Rogawski，医学博士、哲学博士）该提案通过更新位于人口最多州首府萨克拉门托的加州大学戴维斯分校健康系统的临床研究中心，为 NINDS 神经科学卓越网络 (NeuroNEXT) 作出贡献 加州大学戴维斯分校 NeuroNEXT 临床研究中心将继续通过减轻神经系统疾病的负担来为 NINDS 的使命做出贡献，并贡献基础设施，扩大 NINDS 测试有前途的新疗法的能力，提高临床试验的效率，并在新机会出现时迅速做出反应，为神经系统疾病患者测试有希望的治疗方法 失调。我们作为现有 NeuroNEXT 站点的经验、加州大学戴维斯分校的神经科学研究卓越性 - 加州大学系统中最全面的校园、强大的转化研究基础设施，位于全国认可、经验丰富且具有竞争力的更新的 NIH CTSA（加州大学戴维斯分校 CTSC）、神经科学研究卓越性、来自加州大学 UC BRAID 药物发现的创新合作药物开发管道 Consortium 是一个国家远程医疗卓越中心，其战略定位是促进社区外展、创新信息学（例如用于病例识别的系留元数据注册表）以及访问在具有活跃临床关系的高排名区域卫生系统中管理的各种神经系统疾病患者，所有这些都协同工作，使加州大学戴维斯分校继续成为 NeuroNEXT 网络的杰出临床研究站点。加州大学戴维斯分校 NeuroNEXT 的目标是： 1) 利用现有资源和专业知识作为 NeuroNEXT 中心，实施多中心神经科学临床试验，提高在加州大学戴维斯分校进行的试验的效率和质量； 2) 与加州大学UC BRAID药物发现联盟合作，作为NeuroNEXT的核心资源，并作为跨转化谱创新治疗开发的催化剂； 3) 提供当地和区域社区外展服务，以改善患者招募和保留，并将社区合作伙伴充分融入转化研究企业； 4) 有效利用、多样化和利用创新的远程医疗和信息学资源进行临床试验； 5) 为不同的早期职业研究人员提供协作和创新的临床研究培训和支持环境，以培养额外的研究技能并成为独立的临床研究人员。我们迄今为止在地方、区域和全国范围内取得的成就为未来的成功奠定了卓越的基础。

项目成果

The role of the neuromuscular medicine and physiatry specialists in the multidisciplinary management of neuromuscular disease.

神经肌肉医学和理疗专家在神经肌肉疾病的多学科治疗中的作用。

• DOI: 10.1016/j.pmr.2012.06.010
• 发表时间: 2012
• 期刊: Physical medicine and rehabilitation clinics of North America
• 影响因子: 1.7
• 作者: McDonald,CraigM;FowlerJr,WilliamM
• 通讯作者: FowlerJr,WilliamM