Caenorhabditis Intervention Testing Program - Data Coordination Center - Transfer from Buck Institute

秀丽隐杆线虫干预测试计划 - 数据协调中心 - 转自巴克研究所

• 批准号: 10598254
• 负责人: Patrick C. Phillips
• 金额: $ 12.49万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-15 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10598254
• 关键词: Aging; Animal Model; Biological Assay; Biology of Aging; Caenorhabditis; Caenorhabditis elegans; Caregivers; Chemicals; Clinical Sciences; Data; Data Coordinating Center; Deterioration; Diabetes Mellitus; Disease; Disease susceptibility; Elderly; Funding; Genes; Health; Heart; Human; Impaired cognition; Institutes; Intervention; Laboratories; Lead; Life; Link; Longevity; Malignant Neoplasms; Medical Research; Nematoda; Neurodegenerative Disorders; Oregon; Pharmacology; Population; Process; Quality of life; Resistance; Risk Factors; Science; Site; Societies; Testing; Translating; healthspan; healthy aging; improved; pre-clinical; programs; success

Caenorhabditis Intervention Testing Program at Oregon Bridge Funding Request Health challenges linked to human aging take a tremendous toll on society. Physical and cognitive decline limit the quality of life for the elderly and their caregivers. Aging is the major risk factor for, and possible cause of, cancer, diabetes, and neurodegenerative disease. Without question, the promotion of healthy aging with extended resistance to decline and disease should be a major objective of current medical research. Fortunately, tremendous progress has been made in the biology of aging field and the science is poised to be translated into preclinical and clinical science. Simple animals models such as the nematode Caenorhabditis elegans have been at the heart of this success. Many genes and chemical compound interventions that modulate aging processes are likely to act similarly in humans. The Caenorhabditis Intervention Testing Program (CITP) aims to capitalize upon these unique strengths to identify and robustly test a wide range of compounds for potential life and healthspan extending effects. The CITP consists of a co-operative scientific group involving three closely interacting laboratories who coordinately test pharmacological interventions for their ability to extend healthy aging and promote longevity in nematodes. This application is to request bridge funding for the highly successful Caenorhabditis Intervention Testing Program (CITP) to fill a gap between funding cycles.

俄勒冈州桥梁资金申请的小杆线虫干预测试计划 与人类老龄化相关的健康挑战给社会带来巨大损失。身体和认知能力下降极限 老年人及其照顾者的生活质量。衰老是主要的风险因素，也是可能的原因， 癌症、糖尿病和神经退行性疾病。毫无疑问，促进健康老龄化， 对衰退和疾病的长期抵抗力应该是当前医学研究的一个主要目标。 幸运的是，衰老生物学领域已经取得了巨大进展，并且这门科学即将成为 转化为临床前和临床科学。简单的动物模型，如线虫小杆线虫 优雅的人是成功的核心。许多基因和化合物干预措施， 调节衰老过程可能在人类中起类似的作用。隐杆线虫干预试验 CITP计划旨在利用这些独特的优势来识别和有力地测试各种 化合物的潜在寿命和健康延长的效果。CITP由一个合作的科学 一个由三个密切互动的实验室组成的小组，他们协调测试药物干预， 它们能够延长线虫的健康衰老和促进长寿。此申请是为了请求桥梁 为非常成功的小杆线虫干预测试计划（CITP）提供资金，以填补 融资周期。