Caenorhabditis Intervention Testing Program (CITP) at the University of Oregon

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Caenorhabditis Intervention Testing Program at Oregon Bridge Funding Request Health challenges linked to human aging take a tremendous toll on society. Physical and cognitive decline limit the quality of life for the elderly and their caregivers. Aging is the major risk factor for, and possible cause of, cancer, diabetes, and neurodegenerative disease. Without question, the promotion of healthy aging with extended resistance to decline and disease should be a major objective of current medical research. Fortunately, tremendous progress has been made in the biology of aging field and the science is poised to be translated into preclinical and clinical science. Simple animals models such as the nematode Caenorhabditis elegans have been at the heart of this success. Many genes and chemical compound interventions that modulate aging processes are likely to act similarly in humans. The Caenorhabditis Intervention Testing Program (CITP) aims to capitalize upon these unique strengths to identify and robustly test a wide range of compounds for potential life and healthspan extending effects. The CITP consists of a co-operative scientific group involving three closely interacting laboratories who coordinately test pharmacological interventions for their ability to extend healthy aging and promote longevity in nematodes. This application is to request bridge funding for the highly successful Caenorhabditis Intervention Testing Program (CITP) to fill a gap between funding cycles.